ID V6L2H9_9ACTN Unreviewed; 620 AA.
AC V6L2H9;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Membrane transport protein MMPL domain-containing protein {ECO:0000259|Pfam:PF03176};
DE Flags: Fragment;
GN ORFNames=N566_10525 {ECO:0000313|EMBL:EST37901.1};
OS Streptomycetaceae bacterium MP113-05.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae.
OX NCBI_TaxID=1380770 {ECO:0000313|EMBL:EST37901.1, ECO:0000313|Proteomes:UP000017915};
RN [1] {ECO:0000313|EMBL:EST37901.1, ECO:0000313|Proteomes:UP000017915}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MP113-05 {ECO:0000313|EMBL:EST37901.1,
RC ECO:0000313|Proteomes:UP000017915};
RA Valde M., Degnes K.F., Sletta H., Ruckert C., Kalinowski J., Zotchev S.B.;
RT "Streptomyces bacterium from a marine sponge: physiological
RT characterization and genome-based analysis of secondary metabolite
RT biosynthesis potential.";
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EST37901.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AWQV01000341; EST37901.1; -; Genomic_DNA.
DR AlphaFoldDB; V6L2H9; -.
DR STRING; 1380770.N566_10525; -.
DR HOGENOM; CLU_005108_1_3_11; -.
DR Proteomes; UP000017915; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000017915};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 172..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 359..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 520..541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 548..568
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 588..606
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..358
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 444..615
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT REGION 85..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 620
FT /evidence="ECO:0000313|EMBL:EST37901.1"
SQ SEQUENCE 620 AA; 63651 MW; 1EC4116BD8D8705B CRC64;
MVLIGWLAAV GGLHAAQSVF GGSYADDFTL SDSQSQQGLD VLQRHQSDRG GQSSLVVLHD
GQPLSQHQQQ VSTVVGNLGD LPHVLSAQNP LTAPKPQADG TPTAPLSPVS KDGRTAYVTV
TFDENPASLG DSYLDGVDDA VEPLRKAGVQ AEYGGGLGEL DRPEAADGVS EAIGYGVAVV
VLLIGFGSVL AAAVPLVAAL AAVLVGLSCL ALIAAATTFA QVSPTLATMI GLGVGIDYAL
FLLTRHRQDL MDGADPVGAA GRATHTSGRA VLVSGTTVIV ALAGLNASGV GFIGKLGAAA
AVTVVTAVIG ALTLVPALLG LAGRAIDRFH VRRPVAESSA ESGGGFWHRY ALRVGRRPWR
YLAAGLVVLA VLTVPLFSLR LGHIDDGADP TSYTDRRAYD LVTDAFGAGA NGPLTVVVDQ
TGVSSQNRGG LQNSVAASLK GLSGAAAIST LQPTQDGDVL TATVIPAQRP QSAVTTDLVH
RLTGTVLPQA VSGTDAQGYV TGSTAGQTDF RDVVAERLPL IIAVVVLLAM LIILTVFRGV
LVAVKAAVLN LVSIGASYGV VVAVFQWGWG GPALGVSGTV PVESYVPMMM FAIVFGLSMD
YEIFLLSRVH EAWLRTGDSR
//
