ID V6L392_STRRC Unreviewed; 324 AA.
AC V6L392;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=D-cysteine desulfhydrase {ECO:0000313|EMBL:EST35674.1};
GN ORFNames=M878_04690 {ECO:0000313|EMBL:EST35674.1};
OS Streptomyces roseochromogenus subsp. oscitans DS 12.976.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1352936 {ECO:0000313|EMBL:EST35674.1, ECO:0000313|Proteomes:UP000017984};
RN [1] {ECO:0000313|EMBL:EST35674.1, ECO:0000313|Proteomes:UP000017984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DS 12.976 {ECO:0000313|EMBL:EST35674.1,
RC ECO:0000313|Proteomes:UP000017984};
RX PubMed=24407645;
RA Ruckert C., Kalinowski J., Heide L., Apel A.K.;
RT "Draft Genome Sequence of Streptomyces roseochromogenes subsp. oscitans DS
RT 12.976, Producer of the Aminocoumarin Antibiotic Clorobiocin.";
RL Genome Announc. 2:e01147-e01113(2014).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SIMILARITY: Belongs to the ACC deaminase/D-cysteine desulfhydrase
CC family. {ECO:0000256|ARBA:ARBA00008639}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EST35674.1}.
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DR EMBL; AWQX01000045; EST35674.1; -; Genomic_DNA.
DR RefSeq; WP_023544943.1; NZ_CM002285.1.
DR AlphaFoldDB; V6L392; -.
DR STRING; 1352936.M878_04690; -.
DR PATRIC; fig|1352936.5.peg.1009; -.
DR HOGENOM; CLU_048897_1_0_11; -.
DR OrthoDB; 9801249at2; -.
DR Proteomes; UP000017984; Chromosome.
DR GO; GO:1901605; P:alpha-amino acid metabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.1100; -; 2.
DR InterPro; IPR027278; ACCD_DCysDesulf.
DR InterPro; IPR001926; TrpB-like_PALP.
DR InterPro; IPR036052; TrpB-like_PALP_sf.
DR PANTHER; PTHR43780; 1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED; 1.
DR PANTHER; PTHR43780:SF2; 1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED; 1.
DR Pfam; PF00291; PALP; 1.
DR PIRSF; PIRSF006278; ACCD_DCysDesulf; 1.
DR SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR006278-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000017984}.
FT DOMAIN 8..300
FT /note="Tryptophan synthase beta chain-like PALP"
FT /evidence="ECO:0000259|Pfam:PF00291"
FT ACT_SITE 75
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR006278-1"
FT MOD_RES 48
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR006278-2"
SQ SEQUENCE 324 AA; 32376 MW; 4438D0E29842F8A8 CRC64;
MSHSSVPLGT FPTPVEPAPR LAAALGLGPE DLWIKRDDLT GLGGGGNKIR KLEWTAGAAL
AEGADTLVTT GAPQSNHARL TAAAAARLGL DAVLVLRGSP GASRSGNLAL DGLFGARLAW
AGEVDQAGLD AAAAEVCARL RARGARPALI PFGGSGVLGA RGYVRCGEEL DEQLPQLRTV
VVALGSGGTM AGLVAALGAG AVLGVDVGAL ADPAAAVAEF AAPLTTEQVT AEGLRVRRDQ
VGAGYAALTG PVAQALRLAA RTEGLVLDPI YTGRALAGLR AAVRDGDVRP GEKTVFVHTG
GLPGLFGHPD AVAFAEEGAA AFEG
//
