ID   V6LPX4_9EUKA            Unreviewed;       289 AA.
AC   V6LPX4;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Aldose reductase {ECO:0000313|EMBL:EST45761.1};
GN   ORFNames=SS50377_14332 {ECO:0000313|EMBL:EST45761.1};
OS   Spironucleus salmonicida.
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Hexamitinae;
OC   Spironucleus.
OX   NCBI_TaxID=348837 {ECO:0000313|EMBL:EST45761.1};
RN   [1] {ECO:0000313|EMBL:EST45761.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Xu F., Jerlstrom-Hultqvist J., Einarsson E., Astvaldsson A., Svard S.G.,
RA   Andersson J.O.;
RT   "The Genome of Spironucleus salmonicida Highlights a Fish Pathogen Adapted
RT   to Fluctuating Environments.";
RL   PLoS Genet. 0:0-0(2014).
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DR   EMBL; KI546089; EST45761.1; -; Genomic_DNA.
DR   AlphaFoldDB; V6LPX4; -.
DR   EnsemblProtists; EST45761; EST45761; SS50377_14332.
DR   VEuPathDB; GiardiaDB:SS50377_22077; -.
DR   OrthoDB; 5484131at2759; -.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR   GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR   CDD; cd19128; AKR_GlAR-like; 1.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR   PANTHER; PTHR11732:SF507; ALDO_KET_RED DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR   PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE   4: Predicted;
FT   DOMAIN          16..267
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   ACT_SITE        48
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT   BINDING         106
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            75
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ   SEQUENCE   289 AA;  33968 MW;  0A9D5185B8D544D2 CRC64;
     MKSLLIYSRM WPPQLGYGTY KITESLSKES LKIAFDAGYR HIDCAAYYGN EAFLGIALSE
     LFKTYNRKDF FITSKIWPTM MQNVKDQLLI TLQDLQIEYL DLYLIHQPIV WDMDTQSISK
     KSLEQVWVEM EGCQRENLTK NIGVSNYSTK LVTELLNYCT IKPFMNQIEC SLEFQNDKVI
     KFCIEHNIHV TGYRTLMKSQ GTFDNISELK QMATKYNKTI PQIVIKWHLQ KWPKNYSILV
     KSANKSRCQQ NIDINDFALT KEEMIFLQTL DQNKRTCPGL PEWKLEMNE
//