ID V6M6S7_9EUKA Unreviewed; 2095 AA.
AC V6M6S7;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Kinase, PIKK {ECO:0000313|EMBL:EST49124.1};
GN ORFNames=SS50377_10610 {ECO:0000313|EMBL:EST49124.1}, SS50377_24864
GN {ECO:0000313|EMBL:KAH0572751.1};
OS Spironucleus salmonicida.
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Hexamitinae;
OC Spironucleus.
OX NCBI_TaxID=348837 {ECO:0000313|EMBL:EST49124.1};
RN [1] {ECO:0000313|EMBL:KAH0572751.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 50377 {ECO:0000313|EMBL:KAH0572751.1};
RX PubMed=24516394;
RA Xu F., Jerlstrom-Hultqvist J., Einarsson E., Astvaldsson A., Svard S.G.,
RA Andersson J.O.;
RT "The Genome of Spironucleus salmonicida Highlights a Fish Pathogen Adapted
RT to Fluctuating Environments.";
RL PLoS Genet. 10:E1004053-E1004053(2014).
RN [2] {ECO:0000313|EMBL:EST49124.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu F., Jerlstrom-Hultqvist J., Einarsson E., Astvaldsson A., Svard S.G.,
RA Andersson J.O.;
RT "The Genome of Spironucleus salmonicida Highlights a Fish Pathogen Adapted
RT to Fluctuating Environments.";
RL PLoS Genet. 0:0-0(2014).
RN [3] {ECO:0000313|EMBL:KAH0572751.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 50377 {ECO:0000313|EMBL:KAH0572751.1};
RA Xu F., Kurt Z., Jimenez-Gonzalez A., Astvaldsson A., Andersson J.O.,
RA Svard S.G.;
RT "New Spironucleus salmonicida genome in near-complete chromosomes.";
RL Submitted (DEC-2020) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI545956; EST49124.1; -; Genomic_DNA.
DR EMBL; AUWU02000005; KAH0572751.1; -; Genomic_DNA.
DR EnsemblProtists; EST49124; EST49124; SS50377_10610.
DR VEuPathDB; GiardiaDB:SS50377_24864; -.
DR OrthoDB; 8448at2759; -.
DR Proteomes; UP000018208; Unassembled WGS sequence.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF9; SERINE_THREONINE-PROTEIN KINASE MTOR; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EST49124.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000018208};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1054..1610
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 1777..2090
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 2095 AA; 244201 MW; E7DF481F5407E8A6 CRC64;
MCYHETDEVR MICYLVLIKS IKTLDNVVLT QNILSRIIDQ ICGEKCNNNT QLSLTILTQN
DIIHLMLYEN FLDQITALIY ATDIEIQIKT VILLSKLFKY DITGLKSQVL REHFFFCLNG
LQNINPDIGK IKFISRCLND AHDVFLVHQP IIAKIFSKVK FNLWNEESIV QVITGFSGFF
KFLQIDIRDY LEGFMEQLTY LIMNDSDKII KAVLLALHEI VRSQASSILY YLLVPQLFPR
LIYFIKNKKN NEIYLEATKA LVILGPINSE IDLSKIEKEC TNTFLQNSQT YNNMILVKHI
NQQRKVTAID SHGIVIFDQV NQRITDMSSV LYKQSDLNFH HDNITSEILN CIFWSMKCEI
SNARISSIVA FKNILLHSSE KQLKFDVLRH VTRICEFLKS SDDFYFQLIV IQNLTHIVQY
ISYILPFMQQ IIIEAILKLM SNKNLKSNLL SLIEQITYIL DSTTLAYKQD IFQFVFQNFE
KDSSMELAKR TLTTILVLKK QIESEIHLLI PQILKSTQYF QDTIYVEKAL DVVMRIFCYF
KAGKQFSNII YQYLLKFYNT DTKNFYFIAI CCIFDTKLLY FLIQKRKLFE QTPPYLQNLL
LAVKLLDERG FILNKYYLLG CFNSINNQCI EPIYLNYPDI KLDFTNVEYL AKQISENQTP
LSLTLNQPYL FGAALVSIKQ ESLVLKADTD IWKSPNCNNT EEWNQWFSIF IANLIKQSAN
KFIASCFNLA SLSVMNQQTL INFSIFELLQ NEQKRITYLS LISNVTKKIF SNTVPFNIQL
YFINMIDFLN RNSVDISYLM NYDTIAELSD KYQAYNRSLR IREVLYDQSS AQYVDMLFKT
YKRLYFVDSA KSLLKIEQIK LDKQFLLTLG LLAKKYIKYF SKLPFTSSYE TIMQNIEKYD
LQGFQIQFQI ITGNQIYLEN MFLQDTVITA NTVIQTIQLQ FTEFFIQFTE LTFDQKDKIA
ECILAYILTK LKPLFIQIFN PKPAWFEASF DYNQAIQLYT QQQLVIETFL IQETPQSIQR
NPKLIQQLKD SYREYYAISL SKISAQFSLG NYNQLLTDIQ AFKDITESLS YLEPYKKQQY
VEKFNIQIAK YAVEALIDSN YDEASQWVEK IPGKQESSKL LFQIIISTKT NKYTDALEKI
VYLKHILAKQ IQTSIQENYD RAYEQLIDFQ QVIELQEANS FLVAQKQSLE KVTDETSRII
IEKENNKRIK HLQLLWSRRL ANIRQDIEFW ISLVRIRKLI IPVHQDYSAY VSFANQALKS
GRIYLARNLI ESLFNKKPQN LFRMYHNNNK QYSINSDNLD ILIPPLEIQS SEVIYCYSKL
LFKDYKIENK VAGFVHLTRL ALQLKEGDIL IEKVHFKIVE MLKTLEQQQT HLKDDDIHDS
LVNNIYRIYN SQNSNSITSE QTDSDVYSST LSQLSDSSRT FTDKSSLIKI LVRNQTKQCF
KITSDMSSNE EILQILETGA AVAQNCDLLA FRAAEVSFQL FNQEPLDLSI SSISLSSTNV
ISKTSNQKYL EKAIQYLFQA VKNDNLRIQA GLQIINIISQ YQLCDEIEQL VLTSMQETEI
ENWLPILPQL TLYATKYDFK YNQQLQQIIL SLGIKFPQET LTLLYCNANI DNIIIQNQLV
QIIDIIIRNS QDIAIPLLQT LQELNKVSQS TFEKTYDKCQ TFITLLNTNL ISEFFDQFTI
LIQEYNLNSQ IPLEVSFNQL IYPKLIKVWD FFKQSILNLN PSIKDDLISH FIDISSELQE
QIQQQNLPLN SISPFLSQLK QPNFMLFGSN TIKVERFLPQ LLIIPSKQCP RKLGIQATDG
EVYCYLLKGK EDLRQDERVM QFLMFINSIF QTERIAFSTD ITVHFYPVIP LSSQSGLIFW
VPKTCSLLDI IQKQRKSQNV SESTEMNQIM FRADNYSILS LSQRVDAMLF SQLSCPSTDL
RKELFAISCS SENFIERRSP FIATLAAMSA IGHVIGLGDR HPGNILLYNM SSRVLHIDYG
DCFEAAQKRE KFPEKVPFRL TRILEKALDA CGTQGYFKTV LSKCLHVMKH NQSYILTIFR
DFIEQEQLEG MSKKMNGYEL WGNYTDDDQH AVKLITVAEN LENLCQSYAG WAPQW
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