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Database: UniProt
Entry: V6Q9E6_9ENTE
LinkDB: V6Q9E6_9ENTE
Original site: V6Q9E6_9ENTE 
ID   V6Q9E6_9ENTE            Unreviewed;       447 AA.
AC   V6Q9E6;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   25-OCT-2017, entry version 31.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=T233_01601 {ECO:0000313|EMBL:EST89153.1};
OS   Vagococcus lutrae LBD1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Vagococcus.
OX   NCBI_TaxID=1408226 {ECO:0000313|EMBL:EST89153.1, ECO:0000313|Proteomes:UP000018126};
RN   [1] {ECO:0000313|EMBL:EST89153.1, ECO:0000313|Proteomes:UP000018126}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LBD1 {ECO:0000313|EMBL:EST89153.1,
RC   ECO:0000313|Proteomes:UP000018126};
RX   PubMed=24371201;
RA   Lebreton F., Valentino M.D., Duncan L.B., Zeng Q., Manson McGuire A.,
RA   Earl A.M., Gilmore M.S.;
RT   "High-Quality Draft Genome Sequence of Vagococcus lutrae Strain LBD1,
RT   Isolated from the Largemouth Bass Micropterus salmoides.";
RL   Genome Announc. 1:e01087-13(2013).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EST89153.1}.
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DR   EMBL; AYSH01000020; EST89153.1; -; Genomic_DNA.
DR   RefSeq; WP_023606906.1; NZ_AYSH01000020.1.
DR   EnsemblBacteria; EST89153; EST89153; T233_01601.
DR   PATRIC; fig|1408226.3.peg.1558; -.
DR   Proteomes; UP000018126; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018126};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018126}.
FT   DOMAIN      143    274       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      355    424       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     151    158       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   447 AA;  50762 MW;  9BAAC78727C4727D CRC64;
     MPNIEYIWKE LEDTYRKILT TPSFNAWIEQ ATPISLENGI LTIKVPSTLH KDYWEKNLST
     KIVETGFKLT GEEITPVFII ENEQPQPEEP LIDSHTINDQ QAQENSKKAL LNPKYTFDTF
     VIGKGNQMAH AAALVVAEDP GSTYNPLFFY GGVGLGKTHL MHAIGHQMLL NQPNAKVKYV
     SSETFANDFI NSIQNRTSEE FRQEYRNVDL LLVDDIQFFA DKEGTQEEFF HTFNSLYNDG
     RQIVLTSDRL PNEIPKLQER LVSRFAWGLS VDITPPDLET RIAILRKKAD AERLEIPDDT
     LSYIAGQIDS NIRELEGALV RVQAYATMNG ADITTSLAAD SLKTLRPLAP HQQLSILAIQ
     EAVCAYYHID LKDLKGKRRV KKIVLPRQIA MYLSREMTDN SLPKIGAEFG GKDHTTVIHS
     HEKIQQLLEH DTTVQKEIND IKNQLTQ
//
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