ID V6TA92_GIAIN Unreviewed; 429 AA.
AC V6TA92;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Ankyrin repeat protein {ECO:0000313|EMBL:ESU35644.1};
GN ORFNames=DHA2_17552 {ECO:0000313|EMBL:ESU35644.1};
OS Giardia intestinalis (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=5741 {ECO:0000313|EMBL:ESU35644.1, ECO:0000313|Proteomes:UP000018320};
RN [1] {ECO:0000313|Proteomes:UP000018320}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DH {ECO:0000313|Proteomes:UP000018320};
RA Adam R., Dahlstrom E., Martens C., Bruno D., Barbian K., Porcella S.F.,
RA Nash T.;
RT "Genome sequencing of Giardia lamblia Genotypes A2 and B isolates (DH and
RT GS) and comparative analysis with the genomes of Genotypes A1 and E (WB and
RT Pig).";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESU35644.1, ECO:0000313|Proteomes:UP000018320}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DH {ECO:0000313|EMBL:ESU35644.1,
RC ECO:0000313|Proteomes:UP000018320};
RX PubMed=24307482; DOI=10.1093/gbe/evt197;
RA Adam R.D., Dahlstrom E.W., Martens C.A., Bruno D.P., Barbian K.D.,
RA Ricklefs S.M., Hernandez M.M., Narla N.P., Patel R.B., Porcella S.F.,
RA Nash T.E.;
RT "Genome sequencing of Giardia lamblia genotypes A2 and B isolates (DH and
RT GS) and comparative analysis with the genomes of genotypes A1 and E (WB and
RT Pig).";
RL Genome Biol. Evol. 5:2498-2511(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESU35644.1}.
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DR EMBL; AHGT01000073; ESU35644.1; -; Genomic_DNA.
DR AlphaFoldDB; V6TA92; -.
DR EnsemblProtists; ESU35644; ESU35644; DHA2_17552.
DR VEuPathDB; GiardiaDB:DHA2_17552; -.
DR VEuPathDB; GiardiaDB:GL50581_1842; -.
DR VEuPathDB; GiardiaDB:GL50803_0017552; -.
DR VEuPathDB; GiardiaDB:QR46_2723; -.
DR Proteomes; UP000018320; Unassembled WGS sequence.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR24120:SF4; ANKYRIN REPEAT AND SOCS BOX PROTEIN 12; 1.
DR PANTHER; PTHR24120; GH07239P; 1.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT REPEAT 231..263
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 369..409
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 429 AA; 47509 MW; C4CE8C1B9EFE3927 CRC64;
MQRQMRSETS LMLFKAELSK RFKKMPTPQV LPLQRIQLRT PKLPVYVRTG ADTDLVEAAA
KGDVEAVKKN LSQIGLRTTN SSTALMAAAM FNQSEIVKVL REHEARLVDS FGRTALMISA
MLGHADCVDL LVDAEGKMKD TEGWTALMYA CAHDMCPTDK LVEAEATLCD NKGSTALQHA
ISRKNVHAVN KLADREMPLE GITPLMSAAA ANATSQVIEC IARDSGKSDS NGVTALMYAA
SAGSEECVRL LLQDGKEARM QDKEGYTALI RATMRNNVKC VRLLAEREAC ILDSGGWCAL
AYAIYAEFTD CIKILLPLEY TIRDKGKYSI RNLAKRIRDD ETRALLAGDG LQYLISIQYK
DKEDVLGVCT ICLSDLCIMT CIPCGHRCAC IACSEKLVDL NRRNCPMCRA HIEEWKVDLE
EFSQMQDQT
//
