ID V6TF66_GIAIN Unreviewed; 298 AA.
AC V6TF66;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Putative methyltransferase {ECO:0000313|EMBL:ESU37563.1};
GN ORFNames=DHA2_153297 {ECO:0000313|EMBL:ESU37563.1};
OS Giardia intestinalis (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=5741 {ECO:0000313|EMBL:ESU37563.1, ECO:0000313|Proteomes:UP000018320};
RN [1] {ECO:0000313|Proteomes:UP000018320}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DH {ECO:0000313|Proteomes:UP000018320};
RA Adam R., Dahlstrom E., Martens C., Bruno D., Barbian K., Porcella S.F.,
RA Nash T.;
RT "Genome sequencing of Giardia lamblia Genotypes A2 and B isolates (DH and
RT GS) and comparative analysis with the genomes of Genotypes A1 and E (WB and
RT Pig).";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESU37563.1, ECO:0000313|Proteomes:UP000018320}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DH {ECO:0000313|EMBL:ESU37563.1,
RC ECO:0000313|Proteomes:UP000018320};
RX PubMed=24307482; DOI=10.1093/gbe/evt197;
RA Adam R.D., Dahlstrom E.W., Martens C.A., Bruno D.P., Barbian K.D.,
RA Ricklefs S.M., Hernandez M.M., Narla N.P., Patel R.B., Porcella S.F.,
RA Nash T.E.;
RT "Genome sequencing of Giardia lamblia genotypes A2 and B isolates (DH and
RT GS) and comparative analysis with the genomes of genotypes A1 and E (WB and
RT Pig).";
RL Genome Biol. Evol. 5:2498-2511(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESU37563.1}.
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DR EMBL; AHGT01000025; ESU37563.1; -; Genomic_DNA.
DR AlphaFoldDB; V6TF66; -.
DR EnsemblProtists; ESU37563; ESU37563; DHA2_153297.
DR VEuPathDB; GiardiaDB:DHA2_153297; -.
DR VEuPathDB; GiardiaDB:GL50581_2583; -.
DR VEuPathDB; GiardiaDB:GL50803_009130; -.
DR VEuPathDB; GiardiaDB:QR46_3501; -.
DR Proteomes; UP000018320; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR006560; AWS_dom.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR22884:SF413; HISTONE-LYSINE N-METHYLTRANSFERASE CG1716-RELATED; 1.
DR PANTHER; PTHR22884; SET DOMAIN PROTEINS; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51215; AWS; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:ESU37563.1};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ESU37563.1}.
FT DOMAIN 74..119
FT /note="AWS"
FT /evidence="ECO:0000259|PROSITE:PS51215"
FT DOMAIN 149..267
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 276..292
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
SQ SEQUENCE 298 AA; 33787 MW; 65370E76AE089359 CRC64;
MGKVMAMKQG DKLPTAIEPL RVFPYVYKRD ELAKMRRVFA SAIHITEMDA VSLHYTHVKR
NIYVGCKRPS AARKTFCTCT CKEGAGCGTS CELRKVHLEC YKECCAGSPC SKQFIVRPLF
GNSIDPPKDA TTLHKDNSRL ADCGNQRLQR MQYARTAVYP AGRKGYGLFA LTSIQRGALV
TEYIGEVITR EECMRRKKSA KGHLYFLALD RELYIDAAHK GNESRFINHS CDPNCEVQLW
YVGEEPRAAI VALRSIAPHE ELSFDYKFDF YPGVKPKYPC FCGSLYCRGY IDAPKLRT
//
