ID V6TSZ1_GIAIN Unreviewed; 1569 AA.
AC V6TSZ1;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=DEAD/DEAH box helicase {ECO:0000313|EMBL:ESU41836.1};
GN ORFNames=GSB_153766 {ECO:0000313|EMBL:ESU41836.1};
OS Giardia intestinalis (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=5741 {ECO:0000313|EMBL:ESU41836.1, ECO:0000313|Proteomes:UP000018040};
RN [1] {ECO:0000313|Proteomes:UP000018040}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GS {ECO:0000313|Proteomes:UP000018040};
RA Adam R., Dahlstrom E., Martens C., Bruno D., Barbian K., Porcella S.F.,
RA Nash T.;
RT "Genome sequencing of Giardia lamblia Genotypes A2 and B isolates (DH and
RT GS) and comparative analysis with the genomes of Genotypes A1 and E (WB and
RT Pig).";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESU41836.1, ECO:0000313|Proteomes:UP000018040}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS {ECO:0000313|EMBL:ESU41836.1,
RC ECO:0000313|Proteomes:UP000018040};
RX PubMed=24307482; DOI=10.1093/gbe/evt197;
RA Adam R.D., Dahlstrom E.W., Martens C.A., Bruno D.P., Barbian K.D.,
RA Ricklefs S.M., Hernandez M.M., Narla N.P., Patel R.B., Porcella S.F.,
RA Nash T.E.;
RT "Genome sequencing of Giardia lamblia genotypes A2 and B isolates (DH and
RT GS) and comparative analysis with the genomes of genotypes A1 and E (WB and
RT Pig).";
RL Genome Biol. Evol. 5:2498-2511(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESU41836.1}.
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DR EMBL; AHHH01000108; ESU41836.1; -; Genomic_DNA.
DR EnsemblProtists; ESU41836; ESU41836; GSB_153766.
DR VEuPathDB; GiardiaDB:DHA2_153440; -.
DR VEuPathDB; GiardiaDB:GL50581_1612; -.
DR VEuPathDB; GiardiaDB:GL50803_009352; -.
DR VEuPathDB; GiardiaDB:QR46_3275; -.
DR Proteomes; UP000018040; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF4; U5 SMALL NUCLEAR RIBONUCLEOPROTEIN HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF02889; Sec63; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00973; Sec63; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:ESU41836.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 218..411
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 425..629
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1569 AA; 175793 MW; 1C74B878BB27B140 CRC64;
MMTCFIKQFP STHKASKVLF ILERILGPQD DEELHLIIVH VLSALDKESR TAGVSYLEKV
FDAMDPDTST LINDLLDAAV ECREELAELL DQDVLTLNQG PATQQLRDAH LSTILCNEVR
QYFSAFLTAD TLPNKKFSLP APIPEELDNV GTSVVPLLAK PAISTYANRT EYSLVWEAKH
TNESITITSV LDHLQIDPAF AQVYAPVTTF NSVQLQVVDP IFHGGNTLVA APTGAGKTNI
ALWAMICLLH ISQCQHLPVQ LAIYVAPLKA LVREVLSRLE SSLQQLPNSY NAILCEYTGE
ESISLSAISS LLHGLHTSTT LIVLVATPEK LDVFTSKLIG EDFQLIRARL VLVVLDELHL
IGDHTRGSVI EELVLRFHRH YQNTMLLALS ATIPNTQQLA EFLHCAPSNT LVFDSSYRAV
SLHVTVCEMY YKYSEESHLR TTRETFLHSI LPKQLSKGGL LLFTHTRRDA ERLALQLQAK
LCSAEYSKTY ADRSRNKKLY SLLSGNSAVL FHHAGLCRAD RHLVEELFTE KKISVLVSTA
TLAWGVNMPA HTVVILGTRV YTNSQWEALS FADILQMAGR AGRPSFDTYG ECFIIPSPND
THRCLNIFEN RFHIESSFLS SHAAIEKLSK LIITEAFLSA HVFTNEITHI IMSSLFAAQL
LARLPTSIDG SQFIAELTAT LLDCCCSVGL LDTRPDETDP CLLQYHPTFL AQLCIRYYVS
PFTVVRFNAI LLQTPIDTLQ QALLLIATSH EYSPIFIRAD ERFELTSLEE HAPIKYPPFT
TRHELGKICL LLQVYISTGP CYGTISAAFG SLSLMSDYAS IVASAPRVVG CLRELAYFLK
QGQSHQHLNR LYCMLQSRCW PAVLFVREVL GNPLFKSDLL SVHHMKWIEQ LELKQFNSNT
LQKLTLDQLS QIVFPPSAED PPDKREVSRL LTAIIGYPTL RSRLVHLCQL ELEHYELRFQ
CCLVGDQAIL RCSEQTFTLH CVIEAEEKTL KTLSLSMYLN EELDIVLRFR ATDEIWVCHM
HIYLEELLFP VSSMRLDLVG ACPNKNLLAS ASITKHTSDE ATAITSYIQT TIATLGTAPG
STLRPNPILI AGNCLYMQQA EMLNDMLTLI RSTSVNYKID LLATGSTNGF SKQIAQNNDL
PYMNAYTVYK QLGKLFTRPT VIVIPSIADL ASPAGYVLEL LLMRIMKKDP SLPILLISFS
INLIEPSLVA LSLFLDSKSF VISSPDSLLV VQDVPPHVHA ISASLLCDDP DQLHNVYEAL
YLVDDDPELS LLTPFFLCQL LMMCKASGTV YIIVHECILS TTGGMYLQYL NSQLPTADGL
FMLISEQSRD LYAKGFDYVA EHIITADISQ SYLYFSFSVL PGQYVNHRTM VNYHPKPGKE
DYLREEDAML DSLSNWLSEE LIAIEHSVTT LLRAWQQNDY IHPGYICLSM IAAELYTTLD
TNREQAAKSL WFLALSRSVH NFNLLMLCAS SIYDNELADY IHYEKALLLS TGLEVDRAVL
ETLADLVESC AESRVYALLV ALTSLVIRVN EHRDRSVFSN ISSEKLKVLL SNESFAKLCM
DGVRQTNIE
//
