ID V6TWU0_GIAIN Unreviewed; 1540 AA.
AC V6TWU0;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Serine/threonine-protein kinase NEK {ECO:0000313|EMBL:ESU43423.1};
GN ORFNames=GSB_17622 {ECO:0000313|EMBL:ESU43423.1};
OS Giardia intestinalis (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=5741 {ECO:0000313|EMBL:ESU43423.1, ECO:0000313|Proteomes:UP000018040};
RN [1] {ECO:0000313|Proteomes:UP000018040}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GS {ECO:0000313|Proteomes:UP000018040};
RA Adam R., Dahlstrom E., Martens C., Bruno D., Barbian K., Porcella S.F.,
RA Nash T.;
RT "Genome sequencing of Giardia lamblia Genotypes A2 and B isolates (DH and
RT GS) and comparative analysis with the genomes of Genotypes A1 and E (WB and
RT Pig).";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESU43423.1, ECO:0000313|Proteomes:UP000018040}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS {ECO:0000313|EMBL:ESU43423.1,
RC ECO:0000313|Proteomes:UP000018040};
RX PubMed=24307482; DOI=10.1093/gbe/evt197;
RA Adam R.D., Dahlstrom E.W., Martens C.A., Bruno D.P., Barbian K.D.,
RA Ricklefs S.M., Hernandez M.M., Narla N.P., Patel R.B., Porcella S.F.,
RA Nash T.E.;
RT "Genome sequencing of Giardia lamblia genotypes A2 and B isolates (DH and
RT GS) and comparative analysis with the genomes of genotypes A1 and E (WB and
RT Pig).";
RL Genome Biol. Evol. 5:2498-2511(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESU43423.1}.
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DR EMBL; AHHH01000049; ESU43423.1; -; Genomic_DNA.
DR EnsemblProtists; ESU43423; ESU43423; GSB_17622.
DR VEuPathDB; GiardiaDB:DHA2_17622; -.
DR VEuPathDB; GiardiaDB:GL50581_1458; -.
DR VEuPathDB; GiardiaDB:GL50581_392; -.
DR VEuPathDB; GiardiaDB:GL50581_402; -.
DR VEuPathDB; GiardiaDB:GL50803_0017622; -.
DR VEuPathDB; GiardiaDB:QR46_2470; -.
DR Proteomes; UP000018040; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 7.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR PANTHER; PTHR24120:SF4; ANKYRIN REPEAT AND SOCS BOX PROTEIN 12; 1.
DR PANTHER; PTHR24120; GH07239P; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 6.
DR SMART; SM00248; ANK; 23.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Kinase {ECO:0000313|EMBL:ESU43423.1};
KW Transferase {ECO:0000313|EMBL:ESU43423.1}.
FT DOMAIN 11..279
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REPEAT 1360..1392
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1422..1447
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 355..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1540 AA; 168809 MW; 25C624C9822AEADC CRC64;
MNAWTSFENN YDVRHLVSCD DVSTTYTARR KGDGKTVAAR KFLLFLLGPT ERLAMDNEVS
ILQKISHPNI PAYKEIRFSG DSKIMYVITA YIQSETLACF ISNAREQGTH IEERTIWSFI
ADLLDLLQFV LLPHKQYFAD DEHIDFISLD PREIMVDEKG KLYVRSFTYA QPKDESERTI
DRTSLYDCYV PGVFFSTIEQ RNLYKIGLLI YELCLLTPYN YYSPIGPWPA CPAEQIFFPL
HSRELCTLCK DLLDVTKKPR LELSNLIDMS QIRDVHPTFA ADIVESLNQQ TELISSRYNT
DCESFLTHGP SYLSALKQNA SDCSPAADNT AQGIDRGSIE LHTIFTAPIE SLPVSRGAKS
TPKLNSALAQ TSASARPSSP SRILVDSGQL TPILPRQYLE EPKRSISSPP YIKKQSRKAF
EYLAKYPFIK KPSYRVVDAP TNLMKAAIAG DEDLIRLSIT DEAGCALATG ETALYYALLH
KNYQIADLLL ATEGITINDD AFPESVVKNQ ERAFTYGDDR TPLISAAIAN DLVGVYSLIP
LYARLQDTQG KTALMHAIES GYSEVACLLA RSEHGLVDNE GMYATLLSVL HNDPATFKAL
YIKESGLLKG DGFTPLMISA ALDGKASIPT QLQRYKAIRT KKGLTAMMIA VHCSDNPEIL
QELVEHEAGI RDEKGDTALI HAIHAKKESA VHLLAEPEGL LTDTSGKTAL MHAALEGFSQ
AIPILQSQAR KTDNDGKTAL MHAIESGNIA TAAMLASLEA GARDSHGETA LIKALKCELP
AIAKLLIPLE TKYTDLSGNY AARQAILQGN RALIELLVSH EMDLLYNDGF TDLMIAVATF
KMAVVREHLS RDINKQTKSG LTALMVAVLV GNKQAVQILL EERHLVDNNG HKAFDYALKL
NRTEIVRLLE RDTDTVHLSA ELQSPYNAQT STVDQIHRSS ILMTGYRGSI EDMLPVSITK
EGSKQHVFSP KDEQLSHIIT ATPQALVSLE KNVNHADTTH SFTSSTELLK PIRSPITARS
ANTSVLSNGS ANNRSFNSLR RTIEMDKKYD GYEPEARRSS VRLPKRPISA VPTKPVPTAN
PWGATNIDFT TLSLEMDSVS SDFPDAVRVQ SPGIEVADLS CEEFAIQKID DMQKTGGISV
SKSGRNPLLS AVLINDVSAS ARNLNYSGAK FGRSKKTALI VAADKGNTEI VRMLEPREAG
QATTSGWTAL MRAAVHNHVD CVSILMDKEA GLFNHKLMTA LMIATELGHI EVVSRLARLE
AGLRNASYYT ALMLAAKRGY AEIVEILAPH EANYTRSNGA TALMYAIQNR HTSCVRILAD
YEAGMRLDNG WTALMMAAQN GFLDAVELLK SYEGKMQNVN GSTALMLAAQ NKRLAAVKLL
LDIEAAMTNS QGATALMMAA ENGSVAICQM LEPRERGIMT NNGSTALMFA SRAGNTEVAS
LLLNAEAGKQ SGIGHSALML AAQAGAAEVC SLLLKKEQRL RTQDGTTALM MAARAGYRMI
VEMLAPHEAG ARRSDGVTAR VIALSRGHID CAQLLERFEP
//
