ID V6TYW1_GIAIN Unreviewed; 287 AA.
AC V6TYW1;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Nitroreductase family protein {ECO:0000313|EMBL:ESU42175.1, ECO:0000313|EMBL:QBO59753.1};
GN ORFNames=GSB_153178 {ECO:0000313|EMBL:ESU42175.1};
OS Giardia intestinalis (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=5741 {ECO:0000313|EMBL:ESU42175.1, ECO:0000313|Proteomes:UP000018040};
RN [1] {ECO:0000313|Proteomes:UP000018040}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GS {ECO:0000313|Proteomes:UP000018040};
RA Adam R., Dahlstrom E., Martens C., Bruno D., Barbian K., Porcella S.F.,
RA Nash T.;
RT "Genome sequencing of Giardia lamblia Genotypes A2 and B isolates (DH and
RT GS) and comparative analysis with the genomes of Genotypes A1 and E (WB and
RT Pig).";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESU42175.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GS {ECO:0000313|EMBL:ESU42175.1};
RA Feng W., Liu Z., Li S., Tang W., Yang J.;
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ESU42175.1, ECO:0000313|Proteomes:UP000018040}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS {ECO:0000313|EMBL:ESU42175.1,
RC ECO:0000313|Proteomes:UP000018040};
RX PubMed=24307482; DOI=10.1093/gbe/evt197;
RA Adam R.D., Dahlstrom E.W., Martens C.A., Bruno D.P., Barbian K.D.,
RA Ricklefs S.M., Hernandez M.M., Narla N.P., Patel R.B., Porcella S.F.,
RA Nash T.E.;
RT "Genome sequencing of Giardia lamblia genotypes A2 and B isolates (DH and
RT GS) and comparative analysis with the genomes of genotypes A1 and E (WB and
RT Pig).";
RL Genome Biol. Evol. 5:2498-2511(2013).
RN [4] {ECO:0000313|EMBL:QBO59753.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=P344 {ECO:0000313|EMBL:QBO59765.1}, P387
RC {ECO:0000313|EMBL:QBO59762.1}, P413 {ECO:0000313|EMBL:QBO59758.1},
RC P424 {ECO:0000313|EMBL:QBO59757.1}, P427
RC {ECO:0000313|EMBL:QBO59756.1}, P428 {ECO:0000313|EMBL:QBO59755.1},
RC P433 {ECO:0000313|EMBL:QBO59754.1}, and P458
RC {ECO:0000313|EMBL:QBO59753.1};
RA Saghaug C.S., Klotz C., Kallio J.P., Brattbakk H.-R., Stokowy T.,
RA Aebischer T., Kursula I., Langeland N., Hanevik K.;
RT "Genetic variation in metronidazole metabolism and oxidative stress
RT pathways in clinical Giardia lamblia assemblage A and B isolates.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AHHH01000093; ESU42175.1; -; Genomic_DNA.
DR EMBL; MK043723; QBO59753.1; -; Genomic_DNA.
DR EMBL; MK043724; QBO59754.1; -; Genomic_DNA.
DR EMBL; MK043725; QBO59755.1; -; Genomic_DNA.
DR EMBL; MK043726; QBO59756.1; -; Genomic_DNA.
DR EMBL; MK043727; QBO59757.1; -; Genomic_DNA.
DR EMBL; MK043728; QBO59758.1; -; Genomic_DNA.
DR EMBL; MK043732; QBO59762.1; -; Genomic_DNA.
DR EMBL; MK043735; QBO59765.1; -; Genomic_DNA.
DR AlphaFoldDB; V6TYW1; -.
DR EnsemblProtists; ESU42175; ESU42175; GSB_153178.
DR VEuPathDB; GiardiaDB:DHA2_153380; -.
DR VEuPathDB; GiardiaDB:GL50581_3829; -.
DR VEuPathDB; GiardiaDB:GL50803_006175; -.
DR VEuPathDB; GiardiaDB:QR46_2761; -.
DR Proteomes; UP000018040; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.30.70.20; -; 2.
DR Gene3D; 3.40.109.10; NADH Oxidase; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR029479; Nitroreductase.
DR InterPro; IPR000415; Nitroreductase-like.
DR PANTHER; PTHR43122; FERREDOXIN SUBUNIT OF PYRUVATE:FLAVODOXIN OXIDOREDUCTASE-RELATED; 1.
DR PANTHER; PTHR43122:SF1; IRON-SULFUR-BINDING PROTEIN-RELATED; 1.
DR Pfam; PF14697; Fer4_21; 1.
DR Pfam; PF00881; Nitroreductase; 1.
DR SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51379; 4FE4S_FER_2; 2.
PE 4: Predicted;
FT DOMAIN 13..42
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 44..74
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
SQ SEQUENCE 287 AA; 31892 MW; 6C9AACCFD47F7B6D CRC64;
MLINIFATLN MSRFPEVDED LCIGCNVCVQ GCPTQCIEVN KKTRKLVFRA KEACISCGHC
ASVCRTAAIS MFGILPDAIE EEIMTDKPIV RGIKMIRQHR FFKSTPVLPQ DIAQILSIAK
YSDVNLGGPP LCFTAVDLKR KDTDTIIDSL VNALSTNPKY SWLLKVRANG SDPIFHGAPW
LILVSTEHRD SETNEGDLNL DAFAHAHILY RDIQIHSEVR GYGTHLCRIL QSYLSDVHGL
SDSRPNIFDV SPSHMVLLAF VLGVGAMKYH RPLLIPDLVE GADVTFL
//
