GenomeNet

Database: UniProt
Entry: V6U0H2_GIAIN
LinkDB: V6U0H2_GIAIN
Original site: V6U0H2_GIAIN 
ID   V6U0H2_GIAIN            Unreviewed;       548 AA.
AC   V6U0H2;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   28-JUN-2023, entry version 24.
DE   RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
DE   Flags: Fragment;
GN   ORFNames=GSB_94003 {ECO:0000313|EMBL:ESU44496.1};
OS   Giardia intestinalis (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=5741 {ECO:0000313|EMBL:ESU44496.1, ECO:0000313|Proteomes:UP000018040};
RN   [1] {ECO:0000313|Proteomes:UP000018040}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=GS {ECO:0000313|Proteomes:UP000018040};
RA   Adam R., Dahlstrom E., Martens C., Bruno D., Barbian K., Porcella S.F.,
RA   Nash T.;
RT   "Genome sequencing of Giardia lamblia Genotypes A2 and B isolates (DH and
RT   GS) and comparative analysis with the genomes of Genotypes A1 and E (WB and
RT   Pig).";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ESU44496.1, ECO:0000313|Proteomes:UP000018040}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GS {ECO:0000313|EMBL:ESU44496.1,
RC   ECO:0000313|Proteomes:UP000018040};
RX   PubMed=24307482; DOI=10.1093/gbe/evt197;
RA   Adam R.D., Dahlstrom E.W., Martens C.A., Bruno D.P., Barbian K.D.,
RA   Ricklefs S.M., Hernandez M.M., Narla N.P., Patel R.B., Porcella S.F.,
RA   Nash T.E.;
RT   "Genome sequencing of Giardia lamblia genotypes A2 and B isolates (DH and
RT   GS) and comparative analysis with the genomes of genotypes A1 and E (WB and
RT   Pig).";
RL   Genome Biol. Evol. 5:2498-2511(2013).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESU44496.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AHHH01000021; ESU44496.1; -; Genomic_DNA.
DR   AlphaFoldDB; V6U0H2; -.
DR   EnsemblProtists; ESU44496; ESU44496; GSB_94003.
DR   VEuPathDB; GiardiaDB:DHA2_94003; -.
DR   VEuPathDB; GiardiaDB:GL50581_168; -.
DR   VEuPathDB; GiardiaDB:GL50803_0094003; -.
DR   VEuPathDB; GiardiaDB:QR46_4164; -.
DR   Proteomes; UP000018040; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.25.10; Laminin; 5.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR013111; EGF_extracell.
DR   PANTHER; PTHR24033; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR24033:SF151; LAMININ SUBUNIT GAMMA-2; 1.
DR   Pfam; PF00008; EGF; 1.
DR   Pfam; PF07974; EGF_2; 1.
DR   SMART; SM00181; EGF; 10.
DR   SUPFAM; SSF57196; EGF/Laminin; 1.
DR   PROSITE; PS00022; EGF_1; 4.
DR   PROSITE; PS01186; EGF_2; 2.
DR   PROSITE; PS50026; EGF_3; 5.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        485..509
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          40..77
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          78..119
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          133..170
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          209..249
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          340..380
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DISULFID        67..76
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        109..118
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        160..169
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        239..248
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        351..368
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ESU44496.1"
SQ   SEQUENCE   548 AA;  57802 MW;  C387C90D079B1868 CRC64;
     VCNERGICKM GGCQCLTGFS GPKCENVYCG AQADYNYIDE YNNPRWILCN AGGTCVETGE
     GEYQCQCRAH FTGVFCQEFN CINNSSCLNG GTCFFTTSPY ISSTSHCKCL DGFSGLDCGI
     NSCGVEQDQQ TGKSRLCSDS GSCIVGSRLT NEMPLYQCEC RVGHYGSACE TFNCDISPNA
     CNGGVCVIET TGDMTCKLCP EFFYGNDCGN NPCGIDSAGV ACSGHGTCVE EGESAKCRCK
     PGRMGDVCSL RDCLTPGNEC LNGGTCIDAL SALQLGLLEQ SEYNSMNSLA RLKGEDVRSA
     GSTVCMCPKG YTGEFCTECD ATTELATQVF SNGTKASVCA HKSCFYNGFV CSNRGTCSYN
     ETSDSFGCVC ESGYRLLGAQ CWHPSCPIEV RGEKNLPCGI GGQCLETSLG SDEWQCSCAN
     THKLDSSTGL CWPIACFGSS SKSGKVCGGG GVCDLSTYTG THVCNCKDGF KKGSDGITCV
     PSSSVIALAV IVPILLILTA GGLCTYFLVC RGKRRRPAKQ AASAGPNYIR MNDGDAIRNI
     MGGGPQTL
//
DBGET integrated database retrieval system