ID V6U0H2_GIAIN Unreviewed; 548 AA.
AC V6U0H2;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 28-JUN-2023, entry version 24.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
DE Flags: Fragment;
GN ORFNames=GSB_94003 {ECO:0000313|EMBL:ESU44496.1};
OS Giardia intestinalis (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=5741 {ECO:0000313|EMBL:ESU44496.1, ECO:0000313|Proteomes:UP000018040};
RN [1] {ECO:0000313|Proteomes:UP000018040}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GS {ECO:0000313|Proteomes:UP000018040};
RA Adam R., Dahlstrom E., Martens C., Bruno D., Barbian K., Porcella S.F.,
RA Nash T.;
RT "Genome sequencing of Giardia lamblia Genotypes A2 and B isolates (DH and
RT GS) and comparative analysis with the genomes of Genotypes A1 and E (WB and
RT Pig).";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESU44496.1, ECO:0000313|Proteomes:UP000018040}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS {ECO:0000313|EMBL:ESU44496.1,
RC ECO:0000313|Proteomes:UP000018040};
RX PubMed=24307482; DOI=10.1093/gbe/evt197;
RA Adam R.D., Dahlstrom E.W., Martens C.A., Bruno D.P., Barbian K.D.,
RA Ricklefs S.M., Hernandez M.M., Narla N.P., Patel R.B., Porcella S.F.,
RA Nash T.E.;
RT "Genome sequencing of Giardia lamblia genotypes A2 and B isolates (DH and
RT GS) and comparative analysis with the genomes of genotypes A1 and E (WB and
RT Pig).";
RL Genome Biol. Evol. 5:2498-2511(2013).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESU44496.1}.
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DR EMBL; AHHH01000021; ESU44496.1; -; Genomic_DNA.
DR AlphaFoldDB; V6U0H2; -.
DR EnsemblProtists; ESU44496; ESU44496; GSB_94003.
DR VEuPathDB; GiardiaDB:DHA2_94003; -.
DR VEuPathDB; GiardiaDB:GL50581_168; -.
DR VEuPathDB; GiardiaDB:GL50803_0094003; -.
DR VEuPathDB; GiardiaDB:QR46_4164; -.
DR Proteomes; UP000018040; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR PANTHER; PTHR24033; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24033:SF151; LAMININ SUBUNIT GAMMA-2; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF07974; EGF_2; 1.
DR SMART; SM00181; EGF; 10.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 485..509
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 40..77
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 78..119
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 133..170
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 209..249
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 340..380
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 67..76
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 109..118
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 160..169
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 239..248
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 351..368
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ESU44496.1"
SQ SEQUENCE 548 AA; 57802 MW; C387C90D079B1868 CRC64;
VCNERGICKM GGCQCLTGFS GPKCENVYCG AQADYNYIDE YNNPRWILCN AGGTCVETGE
GEYQCQCRAH FTGVFCQEFN CINNSSCLNG GTCFFTTSPY ISSTSHCKCL DGFSGLDCGI
NSCGVEQDQQ TGKSRLCSDS GSCIVGSRLT NEMPLYQCEC RVGHYGSACE TFNCDISPNA
CNGGVCVIET TGDMTCKLCP EFFYGNDCGN NPCGIDSAGV ACSGHGTCVE EGESAKCRCK
PGRMGDVCSL RDCLTPGNEC LNGGTCIDAL SALQLGLLEQ SEYNSMNSLA RLKGEDVRSA
GSTVCMCPKG YTGEFCTECD ATTELATQVF SNGTKASVCA HKSCFYNGFV CSNRGTCSYN
ETSDSFGCVC ESGYRLLGAQ CWHPSCPIEV RGEKNLPCGI GGQCLETSLG SDEWQCSCAN
THKLDSSTGL CWPIACFGSS SKSGKVCGGG GVCDLSTYTG THVCNCKDGF KKGSDGITCV
PSSSVIALAV IVPILLILTA GGLCTYFLVC RGKRRRPAKQ AASAGPNYIR MNDGDAIRNI
MGGGPQTL
//