ID   V6U2N3_GIAIN            Unreviewed;      1183 AA.
AC   V6U2N3;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Ankyrin repeat protein {ECO:0000313|EMBL:ESU43515.1};
GN   ORFNames=GSB_151929 {ECO:0000313|EMBL:ESU43515.1};
OS   Giardia intestinalis (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=5741 {ECO:0000313|EMBL:ESU43515.1, ECO:0000313|Proteomes:UP000018040};
RN   [1] {ECO:0000313|Proteomes:UP000018040}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=GS {ECO:0000313|Proteomes:UP000018040};
RA   Adam R., Dahlstrom E., Martens C., Bruno D., Barbian K., Porcella S.F.,
RA   Nash T.;
RT   "Genome sequencing of Giardia lamblia Genotypes A2 and B isolates (DH and
RT   GS) and comparative analysis with the genomes of Genotypes A1 and E (WB and
RT   Pig).";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ESU43515.1, ECO:0000313|Proteomes:UP000018040}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GS {ECO:0000313|EMBL:ESU43515.1,
RC   ECO:0000313|Proteomes:UP000018040};
RX   PubMed=24307482; DOI=10.1093/gbe/evt197;
RA   Adam R.D., Dahlstrom E.W., Martens C.A., Bruno D.P., Barbian K.D.,
RA   Ricklefs S.M., Hernandez M.M., Narla N.P., Patel R.B., Porcella S.F.,
RA   Nash T.E.;
RT   "Genome sequencing of Giardia lamblia genotypes A2 and B isolates (DH and
RT   GS) and comparative analysis with the genomes of genotypes A1 and E (WB and
RT   Pig).";
RL   Genome Biol. Evol. 5:2498-2511(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESU43515.1}.
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DR   EMBL; AHHH01000046; ESU43515.1; -; Genomic_DNA.
DR   AlphaFoldDB; V6U2N3; -.
DR   EnsemblProtists; ESU43515; ESU43515; GSB_151929.
DR   VEuPathDB; GiardiaDB:DHA2_151310; -.
DR   VEuPathDB; GiardiaDB:GL50581_4396; -.
DR   VEuPathDB; GiardiaDB:GL50803_0016736; -.
DR   VEuPathDB; GiardiaDB:QR46_0303; -.
DR   Proteomes; UP000018040; Unassembled WGS sequence.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   PANTHER; PTHR24120:SF4; ANKYRIN REPEAT AND SOCS BOX PROTEIN 12; 1.
DR   PANTHER; PTHR24120; GH07239P; 1.
DR   Pfam; PF12796; Ank_2; 2.
DR   SMART; SM00248; ANK; 7.
DR   SUPFAM; SSF48403; Ankyrin repeat; 2.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}.
FT   REGION          256..314
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          935..962
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          369..396
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          862..889
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        256..304
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1183 AA;  130777 MW;  B371474E5AFA8A3C CRC64;
     MSGDDKLRKW FRAIQSGDLN EVERLLPECA GLCGDFGETG LQYAVQMKNP TLVQLLIDYE
     VGIANNEGCT ALIMAALNNS ADLCSILAPL EADIILPDRR DAYMIAAQVG SYDALVALRS
     YFSLVTDSHD LNALDYASMT GNLRCVDEIV THYKPSEQER VYSRALAENE GHHAVVQYFD
     TGNLDHQACE SSRLTDGPAL TTEFTMQSSM LPAQGVQSPR IPLNNLTYSN VTVERQKSIS
     DSAIDADFDE TIADLVDEVP KRDAPEQSPT RRKATKDKGS IKAPKAEKKQ KQKHIDDSKL
     VHTSPLDIHK FSNGSPDGFS SLQSQIASKD SYPYELLRTN QRSKSGMCGS RVGRKGGLTQ
     SSSAILPLLE RKDTEIRNLQ SQLEALTLRR STLMTDSFAM VDACTSCCAE GTSFCEIVFD
     SLLNSKDEFI ERLLDLCIPL FPSSATKRID VCVGTDFAST LLFNEAPAQG AIQNNAACEK
     VEEYSYESLL KAKDLEIDRL QKILFDIDIK LQPQSKREAK LCRELEAKIL KEVELIGIID
     EMTQEIKGLK DKVVLHKKVL ADIQQQGFIS DRRTERDIRL EDLFDQTLRS CDVVREIKQQ
     MIAFKAEFSG YIAQTELLAR TLFNEGGAND LNKSLKRSAS CSKINPLNGT GRIHVPNPPN
     PMSVTLHPPT RSSSFATLQP LKPPLKPTDY SGLLQNKDSC IDRLVALLYV SPNTLYQQPA
     LFSHPNTIEE KEVARERHEE ILAQKDQIIN DLRRELETLF KSISAETVNY KKESLTHVTK
     PPDMVIGDLL SGSDGEEDST EDQKYYMEAL AKLELEHAAM QMEIDTMAKT IAERDNAIMF
     FADHYTKKTN KSAIATETAK VITALELEIT ALKSQLQATK QEITLLRNEA KAAPRSRSPT
     VIGIASARSS EDAPAALGQT ADPLCPIIIP SAPPRRSSLA QQLPQSDESS KDIRASSPSR
     TASLLRQTIT RAKSRTASRT MQLKSQYAER TGLTKLMQAV IDGDARAIGM HLSLLCLVTD
     DGTSALMLAA IHNRLFAIEY LIHGEAGLVD NNGKTALIHA LEKGHIRIAE ILTPYECPDV
     TNVDITHTGS RTTELMTAVL QGDLARAWAL LPMQHGIRDK NGKTALILAI ELRRPAFVRI
     LLPLEHTLCL EDGSSPLDAI MSLKGSDTSI CEIQRIAAEY FGF
//