ID V6U345_GIAIN Unreviewed; 418 AA.
AC V6U345;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 28-JUN-2023, entry version 33.
DE SubName: Full=Dynein heavy chain {ECO:0000313|EMBL:ESU43655.1};
DE Flags: Fragment;
GN ORFNames=GSB_10538 {ECO:0000313|EMBL:ESU43655.1};
OS Giardia intestinalis (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=5741 {ECO:0000313|EMBL:ESU43655.1, ECO:0000313|Proteomes:UP000018040};
RN [1] {ECO:0000313|Proteomes:UP000018040}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GS {ECO:0000313|Proteomes:UP000018040};
RA Adam R., Dahlstrom E., Martens C., Bruno D., Barbian K., Porcella S.F.,
RA Nash T.;
RT "Genome sequencing of Giardia lamblia Genotypes A2 and B isolates (DH and
RT GS) and comparative analysis with the genomes of Genotypes A1 and E (WB and
RT Pig).";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESU43655.1, ECO:0000313|Proteomes:UP000018040}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS {ECO:0000313|EMBL:ESU43655.1,
RC ECO:0000313|Proteomes:UP000018040};
RX PubMed=24307482; DOI=10.1093/gbe/evt197;
RA Adam R.D., Dahlstrom E.W., Martens C.A., Bruno D.P., Barbian K.D.,
RA Ricklefs S.M., Hernandez M.M., Narla N.P., Patel R.B., Porcella S.F.,
RA Nash T.E.;
RT "Genome sequencing of Giardia lamblia genotypes A2 and B isolates (DH and
RT GS) and comparative analysis with the genomes of genotypes A1 and E (WB and
RT Pig).";
RL Genome Biol. Evol. 5:2498-2511(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESU43655.1}.
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DR EMBL; AHHH01000041; ESU43655.1; -; Genomic_DNA.
DR AlphaFoldDB; V6U345; -.
DR EnsemblProtists; ESU43655; ESU43655; GSB_10538.
DR VEuPathDB; GiardiaDB:DHA2_10538; -.
DR VEuPathDB; GiardiaDB:GL50581_3742; -.
DR VEuPathDB; GiardiaDB:GL50803_0017243BA; -.
DR VEuPathDB; GiardiaDB:QR46_1571; -.
DR eggNOG; KOG3595; Eukaryota.
DR Proteomes; UP000018040; Unassembled WGS sequence.
DR GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF8; DYNEINS HEAVY CHAIN; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
PE 4: Predicted;
FT DOMAIN 236..357
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 389..414
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ESU43655.1"
SQ SEQUENCE 418 AA; 47707 MW; E435B6DA1870E094 CRC64;
VTEENINRAR EQYRPVAARA AMLYFLLNSL NVIDHFYQFS LSAFITVFYR AIRLSQKSED
VQERVNILLD ALTFDIYSYA ARGLFERHKL IFISQLCFNV LRKDNNLPAN EFNFLLRGTA
SVSRENALTE FIPTSSWNSV VGLAESIPEI FGKLPDDIEG SAKRWKEWIQ HEQPEREKLP
QDWKNRTSLQ RLCIIRALRP DRLMTAMTDF VSESIGEKYV EALPFSFKNV YADSSKTEPV
FFILSPGVDP VKDVESLGKQ LGFTADNGKF KAISLGQGQE KFAEKAMEDM AQKGGWVLLQ
NIHLMKIWQV KLEKMMEQYC SETAHDNFRL FLSGEPDSDP AVASVLPGIV QMCIKVTNEP
PRGIKANMNR AIGLFTPDTF EMCSKGNEFK SILFALIFFH AIVIERRKFG PIGYVHAV
//
