ID V7BN67_PHAVU Unreviewed; 711 AA.
AC V7BN67;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=Tower domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PHAVU_006G005800g {ECO:0000313|EMBL:ESW18011.1};
OS Phaseolus vulgaris (Kidney bean) (French bean).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Phaseolus.
OX NCBI_TaxID=3885 {ECO:0000313|EMBL:ESW18011.1, ECO:0000313|Proteomes:UP000000226};
RN [1] {ECO:0000313|Proteomes:UP000000226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. G19833 {ECO:0000313|Proteomes:UP000000226};
RX PubMed=24908249; DOI=10.1038/ng.3008;
RA Schmutz J., McClean P.E., Mamidi S., Wu G.A., Cannon S.B., Grimwood J.,
RA Jenkins J., Shu S., Song Q., Chavarro C., Torres-Torres M., Geffroy V.,
RA Moghaddam S.M., Gao D., Abernathy B., Barry K., Blair M., Brick M.A.,
RA Chovatia M., Gepts P., Goodstein D.M., Gonzales M., Hellsten U.,
RA Hyten D.L., Jia G., Kelly J.D., Kudrna D., Lee R., Richard M.M.,
RA Miklas P.N., Osorno J.M., Rodrigues J., Thareau V., Urrea C.A., Wang M.,
RA Yu Y., Zhang M., Wing R.A., Cregan P.B., Rokhsar D.S., Jackson S.A.;
RT "A reference genome for common bean and genome-wide analysis of dual
RT domestications.";
RL Nat. Genet. 46:707-713(2014).
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DR EMBL; CM002293; ESW18011.1; -; Genomic_DNA.
DR RefSeq; XP_007146017.1; XM_007145955.1.
DR AlphaFoldDB; V7BN67; -.
DR STRING; 3885.V7BN67; -.
DR EnsemblPlants; ESW18011; ESW18011; PHAVU_006G005800g.
DR GeneID; 18627360; -.
DR Gramene; ESW18011; ESW18011; PHAVU_006G005800g.
DR KEGG; pvu:PHAVU_006G005800g; -.
DR eggNOG; KOG4751; Eukaryota.
DR OMA; GGDIAHE; -.
DR OrthoDB; 5484321at2759; -.
DR Proteomes; UP000000226; Chromosome 6.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR CDD; cd04493; BRCA2DBD_OB1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 2.
DR InterPro; IPR015525; BRCA2.
DR InterPro; IPR015252; BRCA2_hlx.
DR InterPro; IPR036315; BRCA2_hlx_sf.
DR InterPro; IPR015187; BRCA2_OB_1.
DR InterPro; IPR002093; BRCA2_repeat.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR Pfam; PF09169; BRCA-2_helical; 1.
DR Pfam; PF09103; BRCA-2_OB1; 1.
DR Pfam; PF00634; BRCA2; 2.
DR SUPFAM; SSF81872; BRCA2 helical domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50138; BRCA2_REPEAT; 2.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000000226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 452..518
FT /note="Breast cancer type 2 susceptibility protein helical"
FT /evidence="ECO:0000259|Pfam:PF09169"
FT DOMAIN 525..651
FT /note="BRCA2 OB1"
FT /evidence="ECO:0000259|Pfam:PF09103"
SQ SEQUENCE 711 AA; 78115 MW; B3AD940DC4C71093 CRC64;
MCSWQILSHS PNNFHWQITQ HVSHASPTPL PSPIPLPSMA DLLLQGSSAL LPSHDAVARG
EERAMDETFS FSNSLFTTGS GKKVTISSIG LVRAKTLLDT IDSNIQSTSK LRAFDETIGK
QKLQEDEESP ELKLHTVINS PSVEGLHALN NNFEERNAFK QAPIKFHTAG GRSISISSDA
LKRARSLLGD PDVGDLFEGR DVGDSGFSFP LKRQTDTAAP SDCSTPLVRP VTSGSNFKTK
SFTFPLQSSR QRELSTKFPC EGDGINLAKK FDAVGEESGC GWKSTNACGH KPLYGGSQTL
NSVVYDSSLN GFSSKVDTRG VAIRRALVDV SNTINTDTTN NRQAASGKRR LGLCLTVSPF
KRPRSSNFSA LLEQDVGKSP PDLSQLSSGI SACKGEVSTR YPFHYPRVYI KDYFVGRPME
KRTCFPNLSR QVTSVNAEKY VFHKGSGDNG MGAEAFVHLL ALHGASMHFA TKEWVTNHYK
WIVWKLACYE RYYPASSAGN FLTVSNVLEE LKYRYEREGN HGHRSTIKKI LEGDAMPSSV
MILCISSIHS SYVVESETCF ETKSGAKKTE AVKVELTDGW YSMNAILDVP LSKQQAAGRL
FVGQKLRLSG AGLCGWNGPV SPLEVSSTVS LLLHINGTYR AHWAERLGFC KVAGPPLAFR
CIKSNGGLIP QTLAGITHIY PILYKERLSS GRSVVMSERM ENERTELYNQ R
//
