ID V7C3E7_PHAVU Unreviewed; 894 AA.
AC V7C3E7;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN ORFNames=PHAVU_004G147400g {ECO:0000313|EMBL:ESW24644.1};
OS Phaseolus vulgaris (Kidney bean) (French bean).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Phaseolus.
OX NCBI_TaxID=3885 {ECO:0000313|EMBL:ESW24644.1, ECO:0000313|Proteomes:UP000000226};
RN [1] {ECO:0000313|Proteomes:UP000000226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. G19833 {ECO:0000313|Proteomes:UP000000226};
RX PubMed=24908249; DOI=10.1038/ng.3008;
RA Schmutz J., McClean P.E., Mamidi S., Wu G.A., Cannon S.B., Grimwood J.,
RA Jenkins J., Shu S., Song Q., Chavarro C., Torres-Torres M., Geffroy V.,
RA Moghaddam S.M., Gao D., Abernathy B., Barry K., Blair M., Brick M.A.,
RA Chovatia M., Gepts P., Goodstein D.M., Gonzales M., Hellsten U.,
RA Hyten D.L., Jia G., Kelly J.D., Kudrna D., Lee R., Richard M.M.,
RA Miklas P.N., Osorno J.M., Rodrigues J., Thareau V., Urrea C.A., Wang M.,
RA Yu Y., Zhang M., Wing R.A., Cregan P.B., Rokhsar D.S., Jackson S.A.;
RT "A reference genome for common bean and genome-wide analysis of dual
RT domestications.";
RL Nat. Genet. 46:707-713(2014).
CC -!- SIMILARITY: Belongs to the G-alpha family.
CC {ECO:0000256|ARBA:ARBA00005804}.
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DR EMBL; CM002291; ESW24644.1; -; Genomic_DNA.
DR RefSeq; XP_007152650.1; XM_007152588.1.
DR AlphaFoldDB; V7C3E7; -.
DR STRING; 3885.V7C3E7; -.
DR EnsemblPlants; ESW24644; ESW24644; PHAVU_004G147400g.
DR GeneID; 18633085; -.
DR Gramene; ESW24644; ESW24644; PHAVU_004G147400g.
DR KEGG; pvu:PHAVU_004G147400g; -.
DR eggNOG; KOG0082; Eukaryota.
DR OMA; SENLNCP; -.
DR OrthoDB; 1221906at2759; -.
DR Proteomes; UP000000226; Chromosome 4.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR CDD; cd00066; G-alpha; 1.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10218:SF317; EXTRA-LARGE GUANINE NUCLEOTIDE-BINDING PROTEIN 3-LIKE; 1.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00022707};
KW Myristate {ECO:0000256|ARBA:ARBA00022707};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000226};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT DOMAIN 1..21
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 96..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..203
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 894 AA; 100889 MW; 2FE7BCF6D23AF33F CRC64;
MASESTEEDK SWEQVLRRML PAGAPLPDEE HLDYSIAVEY EGPPVAYDVP KVDPLEIGTA
ASGVAVPIRT ASIVSDHNAS ASIPVAMPVH PRFSRFGRVR NGGFDRPPPP PQKSPVESRR
SSSVSRSQLQ FDSHSGEVVY RSDYSGEMNV DDGASSASEV SAQHSPPNSA PVPRGGSGAG
KRPTTVTFHT PRDSEDDDGD DFPSPRSVAT SPVGASPSRN KKRWICSRCG NSNRLKEKEA
CLVCDSRYCS NCVLKAMGSM PEGRKCVSCI GKPIDESKRP ILGKCSRMLS KVCSSLEINQ
IMKAEKECPA NQLRPEQLIV NGRQLRQEEL AEILGCSIPP QKLKPGRYWY DKDSGLWGKE
GEKPDKIISS KLNIGGKLQT DASNGNTRVY MNGREITKIE LRMLKLANVQ CPRDTHFWVY
EDGSYEEEGQ NNIKGNIWGK ASTRFICSLF SLPVPPTNPP GVRDNSTNYS ARSVPEYLEQ
GRVQKLLLFG MEGSGTATLF KQAKFLYGNK FSTEELQNIK LMIQSNMYKY LSILLEGREQ
FEEESLAERE STSLEGEGSG QVPETAADEN KPCIYSINQR FKHFSDWLLD IMATGDLEAF
FPAATREYAP MVDEIWRDPA VQETYKRREE LHNLPDVAKY FLDRAIEISS NEYEPSDKDV
LYAEGVTQSN GLAFMEFSFD DRSPMSEIYS ENLNCPPPLT KYQLIRINSK GLRDGCKWLE
MFEDVRAIIF CVALSDYDQM WPSSTGQLRN KLLASKDLFE SLVKHPCFKD TPFVLLLNKY
DAFEDKINKV HLSTCEWFGD FCPVRPHHNN HALAHQAYYY VAVKFKELYY YLTGQKLFVG
QTRARERTSV DEAFKYIREI IKWDDEKDDD VYEMNQEESF CSTEMSSSPF VRQE
//
