ID V7CZR3_PHAVU Unreviewed; 714 AA.
AC V7CZR3;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Phenylalanine ammonia-lyase {ECO:0000256|ARBA:ARBA00012139, ECO:0000256|RuleBase:RU003955};
DE EC=4.3.1.24 {ECO:0000256|ARBA:ARBA00012139, ECO:0000256|RuleBase:RU003955};
GN ORFNames=PHAVU_001G177800g {ECO:0000313|EMBL:ESW34750.1};
OS Phaseolus vulgaris (Kidney bean) (French bean).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Phaseolus.
OX NCBI_TaxID=3885 {ECO:0000313|EMBL:ESW34750.1, ECO:0000313|Proteomes:UP000000226};
RN [1] {ECO:0000313|Proteomes:UP000000226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. G19833 {ECO:0000313|Proteomes:UP000000226};
RX PubMed=24908249; DOI=10.1038/ng.3008;
RA Schmutz J., McClean P.E., Mamidi S., Wu G.A., Cannon S.B., Grimwood J.,
RA Jenkins J., Shu S., Song Q., Chavarro C., Torres-Torres M., Geffroy V.,
RA Moghaddam S.M., Gao D., Abernathy B., Barry K., Blair M., Brick M.A.,
RA Chovatia M., Gepts P., Goodstein D.M., Gonzales M., Hellsten U.,
RA Hyten D.L., Jia G., Kelly J.D., Kudrna D., Lee R., Richard M.M.,
RA Miklas P.N., Osorno J.M., Rodrigues J., Thareau V., Urrea C.A., Wang M.,
RA Yu Y., Zhang M., Wing R.A., Cregan P.B., Rokhsar D.S., Jackson S.A.;
RT "A reference genome for common bean and genome-wide analysis of dual
RT domestications.";
RL Nat. Genet. 46:707-713(2014).
CC -!- FUNCTION: This is a key enzyme of plant metabolism catalyzing the first
CC reaction in the biosynthesis from L-phenylalanine of a wide variety of
CC natural products based on the phenylpropane skeleton.
CC {ECO:0000256|ARBA:ARBA00002235}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-phenylalanine = (E)-cinnamate + NH4(+);
CC Xref=Rhea:RHEA:21384, ChEBI:CHEBI:15669, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:58095; EC=4.3.1.24;
CC Evidence={ECO:0000256|ARBA:ARBA00023537,
CC ECO:0000256|RuleBase:RU003955};
CC -!- PATHWAY: Phenylpropanoid metabolism; trans-cinnamate biosynthesis;
CC trans-cinnamate from L-phenylalanine: step 1/1.
CC {ECO:0000256|ARBA:ARBA00005138, ECO:0000256|RuleBase:RU003955}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU003955}.
CC -!- SIMILARITY: Belongs to the PAL/histidase family.
CC {ECO:0000256|ARBA:ARBA00007238, ECO:0000256|RuleBase:RU003954}.
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DR EMBL; CM002288; ESW34750.1; -; Genomic_DNA.
DR RefSeq; XP_007162756.1; XM_007162694.1.
DR AlphaFoldDB; V7CZR3; -.
DR STRING; 3885.V7CZR3; -.
DR EnsemblPlants; ESW34750; ESW34750; PHAVU_001G177800g.
DR GeneID; 18641750; -.
DR Gramene; ESW34750; ESW34750; PHAVU_001G177800g.
DR KEGG; pvu:PHAVU_001G177800g; -.
DR OMA; YSLRCMP; -.
DR OrthoDB; 1030318at2759; -.
DR PhylomeDB; V7CZR3; -.
DR UniPathway; UPA00713; UER00725.
DR Proteomes; UP000000226; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0045548; F:phenylalanine ammonia-lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0009800; P:cinnamic acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-KW.
DR CDD; cd00332; PAL-HAL; 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR InterPro; IPR001106; Aromatic_Lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR InterPro; IPR022313; Phe/His_NH3-lyase_AS.
DR InterPro; IPR005922; Phe_NH3-lyase.
DR InterPro; IPR023144; Phe_NH3-lyase_shielding_dom_sf.
DR NCBIfam; TIGR01226; phe_am_lyase; 1.
DR PANTHER; PTHR10362; HISTIDINE AMMONIA-LYASE; 1.
DR PANTHER; PTHR10362:SF83; PHENYLALANINE AMMONIA-LYASE 1; 1.
DR Pfam; PF00221; Lyase_aromatic; 1.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
DR PROSITE; PS00488; PAL_HISTIDASE; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|RuleBase:RU003954};
KW Phenylalanine catabolism {ECO:0000256|ARBA:ARBA00023232};
KW Phenylpropanoid metabolism {ECO:0000256|ARBA:ARBA00023051,
KW ECO:0000256|RuleBase:RU003955};
KW Reference proteome {ECO:0000313|Proteomes:UP000000226}.
SQ SEQUENCE 714 AA; 77932 MW; 3FCD3DA93A95574D CRC64;
MEATTLTNAQ NGSFCLPSAK TTDPLNWGTA AEALKGSHLD EVKRMVAEYR QPLVRLGGET
LTIAQVAAVS GHDQGVRVEL SESAREGVKA SSEWVMNSMN NGTDSYGVTT GFGATSHRRT
KQGGALQKEL IRFLNAGIFG NGTESSHTLP HTATRAAMLV RINTLLQGYS GIRFEILESI
TKLLNNNVTP CLPLRGTITA SGDLVPLSYI AGLLTGRPNS KAVGPSGEVL TAKQAFELAN
INSEFYELQP KEGLALVNGT AVGSGMASIV LFDANILAVL SEVLSAIFAE VMQGKPEFTD
HLTHKLKHHP GQIEAAAIME HILDGSSYMK DAKKLHEIDP LQKPKQDRYA LRTSPQWLGP
LIEVIRFSTK SIEREINSVN DNPLIDVSRN KALHGGNFQG TPIGVSMDNT RLALASIGKL
MFAQFSELVN DFYNNGLPSN LTASRNPSLD YGFKGAEIAM ASYCSELQYL ANPVTSHVQS
AEQHNQDVNS LGLISARKTN ESIEILKLMS STFLMGLCQA IDLRHLEENL KSSVKNTVSQ
VSKRTLTTGG NGELHPSRFC EKDLLKVVDR EYVFSYIDDP CSGTYPLMQK LRQVLVDHAL
INAENEKDVN TSIFQKIATF EEELKTILPK EVESTRAAYE SGKAAIPNKI KECRSYPLYK
FVREELGTGL LTGEKVKSPG EEFDKLFTAI CQGKIIDPLL ECLGEWNGAP LPIC
//
