ID V7D5W7_9PSED Unreviewed; 424 AA.
AC V7D5W7;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Dihydrothymine dehydrogenase {ECO:0000256|ARBA:ARBA00032722};
DE AltName: Full=Dihydrouracil dehydrogenase {ECO:0000256|ARBA:ARBA00030119};
GN ORFNames=O164_22420 {ECO:0000313|EMBL:ESW37684.1};
OS Pseudomonas taiwanensis SJ9.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=1388762 {ECO:0000313|EMBL:ESW37684.1, ECO:0000313|Proteomes:UP000018511};
RN [1] {ECO:0000313|EMBL:ESW37684.1, ECO:0000313|Proteomes:UP000018511}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SJ9 {ECO:0000313|EMBL:ESW37684.1,
RC ECO:0000313|Proteomes:UP000018511};
RA Hong S.-J., Shin J.-H.;
RT "Whole Genome Shotgun Sequence of Pseudomonas taiwanensis SJ9.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the dihydropyrimidine dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00010804}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESW37684.1}.
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DR EMBL; AXUP01000366; ESW37684.1; -; Genomic_DNA.
DR RefSeq; WP_013973314.1; NZ_AXUP01000366.1.
DR AlphaFoldDB; V7D5W7; -.
DR PATRIC; fig|1388762.3.peg.4322; -.
DR Proteomes; UP000018511; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR CDD; cd02940; DHPD_FMN; 1.
DR Gene3D; 3.30.70.20; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR005720; Dihydroorotate_DH_cat.
DR PANTHER; PTHR43073; DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]; 1.
DR PANTHER; PTHR43073:SF2; DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]; 1.
DR Pfam; PF01180; DHO_dh; 1.
DR Pfam; PF14697; Fer4_21; 1.
DR SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR SUPFAM; SSF51395; FMN-linked oxidoreductases; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51379; 4FE4S_FER_2; 2.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:ESW37684.1}.
FT DOMAIN 336..365
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 373..403
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
SQ SEQUENCE 424 AA; 46154 MW; BA2C8C33807D997D CRC64;
MADLSIEFAG IKAPNPFWLA SAPPTDKAYN VVRAFEAGWG GVVWKTLGED PAAVNVSSRY
SAHYGPNRQV QGINNIELIT DRSLDINLRE ITQVKKDWPD RALIVSLMVP CVEDSWKFIL
PLVEATGADG IELNFGCPHG MPERGMGAAV GQVPEYVEMV TRWCKTYCSL PVIVKLTPNI
TDIRQSARAA HRGGADAVSL INTINSITSV DLDRMVAHPI VGDQSTHGGY CGSAVKPIAL
NMVAEIARDP QTRGLPICGI GGIGSWRDAA EFMALGSGAV QVCTAAMLHG FRIVEDMKDG
LARWMDQHGH RNIEAFRGQA VGHTTDWKYL DMNYKSVAHI DQQACIGCGR CHIACEDTSH
QAIASTLNAD GTHAYSVIEE ECVGCNLCQI TCPVENCIEM VAQDTGKPYL NWTQDPRNPY
REAS
//
