ID V7I5Z7_9CLOT Unreviewed; 1122 AA.
AC V7I5Z7;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=T472_0211755 {ECO:0000313|EMBL:ETA80432.1};
OS Youngiibacter fragilis 232.1.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Youngiibacter.
OX NCBI_TaxID=994573 {ECO:0000313|EMBL:ETA80432.1, ECO:0000313|Proteomes:UP000017747};
RN [1] {ECO:0000313|EMBL:ETA80432.1, ECO:0000313|Proteomes:UP000017747}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=232.1 {ECO:0000313|EMBL:ETA80432.1,
RC ECO:0000313|Proteomes:UP000017747};
RX PubMed=24459265;
RA Wawrik C.B., Callaghan A.V., Stamps B.W., Wawrik B.;
RT "Genome Sequence of Youngiibacter fragilis, the Type Strain of the Genus
RT Youngiibacter.";
RL Genome Announc. 2:e01183-13(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETA80432.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AXUN02000181; ETA80432.1; -; Genomic_DNA.
DR RefSeq; WP_023388009.1; NZ_AXUN02000181.1.
DR AlphaFoldDB; V7I5Z7; -.
DR STRING; 994573.T472_0211755; -.
DR REBASE; 79736; Yfr2321ORF211755P.
DR PATRIC; fig|994573.3.peg.2187; -.
DR eggNOG; COG0827; Bacteria.
DR eggNOG; COG1002; Bacteria.
DR OrthoDB; 32195at2; -.
DR Proteomes; UP000017747; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR047939; BREX_1_PglX.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR011639; MethylTrfase_TaqI-like_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; NF033452; BREX_1_MTaseX; 2.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF1; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF07669; Eco57I; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000017747};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 437..533
FT /note="Type II methyltransferase M.TaqI-like"
FT /evidence="ECO:0000259|Pfam:PF07669"
SQ SEQUENCE 1122 AA; 129325 MW; DD5ED2D78BA1202B CRC64;
MNKNAIQKYA VWARNELIEQ VKQRAYQYGI SAKGYGDENA AVIAGRVLSA DEKRQRAAFV
SEIKRNGFEQ AVEDVAYTWF NRFVALRFME VNDYLQTHVR VFSDASGGFN PEILKDVLHL
ELEGLDKSKV SKMLNANQTE ELYRYLLLTQ CNALNAALPE MFEKLGTYTE MLLPNNILKQ
DSVLARLVKD IDEDDWKDAV QIIGWMYQYY NTEPKQAVFD GLKKNVKITK EKIPAATQLF
TPDWIVRYMV ENSLGRLWLE SHPNPTLKAN WKYYLDEAEQ TPEVAEKLRV MKAQSPVKSP
EDIRLIDPCM GSGHILVYSF DVLMQIYESE GYNPRDAARL ILEKNIYGLD IDCRAYQLAY
FSLMMKARQY NRRIFTDGVK PQVYHPAGFP DGEEYGSLLK VDELEPMPVE NTGQLSIDDT
TYDLQLNAWN FKRLLALKYD VVVTNPPYMG GSGMGSKLSD FVKKNYPDSK SDTFSAFIER
ADQFLTPRGF QSMITMESWM FLSSFEKLRD KIFDSKTIIN LVHMPYLGKG GTSLGINFGT
AAFILYKKRV PGYVSQYDYI RYYETTDEGI PFVFPTINER YKTAKSDDFE LIPGKPVAYW
LSSPLFESFK LNNIGDFLTT REGMATADND RFLRYWHEVV TGSISFSTGN ADEGAKEKRK
WFPYNKGGIF RRWYGNNEYI VNWQNSGLEI RNNIDTKTGR IRSHNYNGAF AFRKGITWSA
LTTGDISIRY CPGGYLFDSK GAMGFAIEQK SLFYCLGLLN SAVAKEYLSF FSPTMDFKVG
DVIQIPLDKS LKHSDEICHI VSNNIEISRS DWDSFEVSWD FKRHPILCGE RTVAAAFAKW
ERETKERFET LKANEEELNR IFIDIYGLQD ELTPEVEDKD VTVRQADLGR EIRSLISYAV
GCMFGRYSLD DEGLAYAGGD WDAGKYRSFT PDKNNILPIC DDEYFDDDIL GRFVDFVRVV
YSAETLEENL KFIADALCGK GTPREAIRNY FLNDFYADHC KMYQKRPIYW LFDSGKKNGF
KSLVYLHRYS RDLLAKLRTD YVHEQQERYR TQLSHIAAAL NTATGSERAR LLKQQDKLSE
QLKEITAFEE KVHHLADQNI EIDLDDGVKK NYEIFTDVLA KI
//