ID   V7I9T9_9CLOT            Unreviewed;       839 AA.
AC   V7I9T9;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
GN   ORFNames=T472_0202975 {ECO:0000313|EMBL:ETA82089.1};
OS   Youngiibacter fragilis 232.1.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Youngiibacter.
OX   NCBI_TaxID=994573 {ECO:0000313|EMBL:ETA82089.1, ECO:0000313|Proteomes:UP000017747};
RN   [1] {ECO:0000313|EMBL:ETA82089.1, ECO:0000313|Proteomes:UP000017747}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=232.1 {ECO:0000313|EMBL:ETA82089.1,
RC   ECO:0000313|Proteomes:UP000017747};
RX   PubMed=24459265;
RA   Wawrik C.B., Callaghan A.V., Stamps B.W., Wawrik B.;
RT   "Genome Sequence of Youngiibacter fragilis, the Type Strain of the Genus
RT   Youngiibacter.";
RL   Genome Announc. 2:e01183-13(2014).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETA82089.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AXUN02000043; ETA82089.1; -; Genomic_DNA.
DR   AlphaFoldDB; V7I9T9; -.
DR   STRING; 994573.T472_0202975; -.
DR   eggNOG; COG2304; Bacteria.
DR   Proteomes; UP000017747; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd00198; vWFA; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10579; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR; 1.
DR   PANTHER; PTHR10579:SF43; LOW QUALITY PROTEIN: EPITHELIAL CHLORIDE CHANNEL PROTEIN-LIKE ISOFORM X1-RELATED; 1.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017747};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           29..839
FT                   /note="VWFA domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004761003"
FT   TRANSMEM        664..690
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          38..224
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
SQ   SEQUENCE   839 AA;  92510 MW;  6C28476B74C16567 CRC64;
     MLKKIKKTMI IFLIALIISS GLPLPAKAAD SLILEKLAVS FVIDTSGSMA STDPARLRET
     AANIFIDLLS PDDNLGVITF NTVTSEVIPM QPVGNAANKG AIKGSLAPRL DADGDTNYQA
     ALQAASAQLS SFTAPDVRKV IIFLTDGVPD PDPAKRNDQV FMDQYMSSMW ATVSDIGLKQ
     YPVYSVGFGA VNQDILNRIA SDTQGEAKFI GDPGELAVTF FNVLGTLKNR RNFLGSNMEL
     NGEQTVDFDF DRYTSQVTMV FANAQPGLQV SLISPEGKPV NENVLVQAND RYTLVTLNQA
     KEELSGKWSV KVNGTGAVRA FGDKDLFLKA WVTKPLANTQ QPVNEPLEIS VGLTGEVGDK
     AIVEALVIKN GKPELTPVIL TEIDGVFSGK YDKTDVQGTY EIQVSVKEDE NLITSTSSKV
     TIRELPILKS DFYSDRMKYK IGGNMTVTGY LEMRGNKVTS NQDLTISTFN LIIDHSDGTE
     ERLTLVDNQD PAYGDLKAGD ATYSTKVSFD SVGTTSAKLL VQGQYKGENF ILEKTLGTYE
     VVEPGNVSVS IDESGLFGVV GTKVKLPVRV SSTSKVRETI LLSLDPGFGT LENSRITLEP
     EESGIKEVVL VLKNSLDIKL HDIKFGIAVE DPLTKLETPE AGFQIDVITK SQERFMNFKR
     NLPLYIAIAG LVIGVPIILI LFGLLLYSML IKPNVIIRGM LLYHKNGDAL VEGAVREIPI
     KSKRKNKIVL SFDKNNTSAD FVIEGSMYKY DIILENEFEQ GRWRFMDGYK ALARKVNRPK
     FTIYTTKPGI FVFRNEVMTK KELYDKDVIE SGGFTFQYYA EKHRMKEKQQ GKDILEGRM
//