ID   V7JI17_MYCAV            Unreviewed;       353 AA.
AC   V7JI17;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   SubName: Full=Polyketide synthase {ECO:0000313|EMBL:ETA96887.1};
GN   ORFNames=O982_14835 {ECO:0000313|EMBL:ETA96887.1};
OS   Mycobacterium avium 10-5581.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=1392000 {ECO:0000313|EMBL:ETA96887.1, ECO:0000313|Proteomes:UP000018557};
RN   [1] {ECO:0000313|EMBL:ETA96887.1, ECO:0000313|Proteomes:UP000018557}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=10-5581 {ECO:0000313|EMBL:ETA96887.1,
RC   ECO:0000313|Proteomes:UP000018557};
RA   Bannantine J.P., Robbe-Austerman S., O'Connell C.;
RT   "Genome sequence of MAC strains.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00005194}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC       synthases family. {ECO:0000256|ARBA:ARBA00005531}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETA96887.1}.
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DR   EMBL; AYNT01000161; ETA96887.1; -; Genomic_DNA.
DR   AlphaFoldDB; V7JI17; -.
DR   PATRIC; fig|1392000.4.peg.3178; -.
DR   UniPathway; UPA00094; -.
DR   Proteomes; UP000018557; Unassembled WGS sequence.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00831; CHS_like; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR   InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR   InterPro; IPR011141; Polyketide_synthase_type-III.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11877:SF99; 1,3,6,8-TETRAHYDROXYNAPHTHALENE SYNTHASE; 1.
DR   PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR   Pfam; PF02797; Chal_sti_synt_C; 1.
DR   Pfam; PF00195; Chal_sti_synt_N; 1.
DR   PIRSF; PIRSF000451; PKS_III; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
PE   3: Inferred from homology;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098}.
FT   DOMAIN          9..196
FT                   /note="Chalcone/stilbene synthase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00195"
FT   DOMAIN          220..351
FT                   /note="Chalcone/stilbene synthase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02797"
FT   ACT_SITE        138
FT                   /note="Acyl-thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000451-1"
SQ   SEQUENCE   353 AA;  37038 MW;  FE8BCE12185B2B23 CRC64;
     MSVIAGVFGA LPPHRYPQRE LTDFFVSIPE FEGYEDIVRQ LHASAKVGSR HLVLPLEQYP
     TLTDFGVANR IFIEHAVTLG CAALSGALDE AGLKPEDLDV LITTTVTGLA VPSVDARIAA
     RLGLRDDVRR VPLFGLGCVA GAAGVARMHD YLRGAPDAVA ALVSVELCSL TYPGYKPSLA
     GLVGSALFAD GAGAVVAVGE RRAEQLDAAG PSVLDSRSHL YPDSLRTMGY DVGATGFELV
     LSKDVAAVVE QYIEDDVTGF LGAHGLTTTD IGAFVSHPGG PKVIEAINAA LGLPPEALEL
     TWRSLGEIGN LSSASVLHVL RDTLAKPPPS DSPGLMLAMG PGFCSELVLL RWH
//