ID V7JNI2_MYCAV Unreviewed; 643 AA.
AC V7JNI2;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Translation initiation factor IF-2 {ECO:0000256|ARBA:ARBA00020675, ECO:0000256|RuleBase:RU000644};
DE Flags: Fragment;
GN ORFNames=O982_05260 {ECO:0000313|EMBL:ETA99895.1};
OS Mycobacterium avium 10-5581.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium avium complex (MAC).
OX NCBI_TaxID=1392000 {ECO:0000313|EMBL:ETA99895.1, ECO:0000313|Proteomes:UP000018557};
RN [1] {ECO:0000313|EMBL:ETA99895.1, ECO:0000313|Proteomes:UP000018557}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10-5581 {ECO:0000313|EMBL:ETA99895.1,
RC ECO:0000313|Proteomes:UP000018557};
RA Bannantine J.P., Robbe-Austerman S., O'Connell C.;
RT "Genome sequence of MAC strains.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: One of the essential components for the initiation of protein
CC synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis
CC and promotes its binding to the 30S ribosomal subunits. Also involved
CC in the hydrolysis of GTP during the formation of the 70S ribosomal
CC complex. {ECO:0000256|RuleBase:RU000644}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733, ECO:0000256|RuleBase:RU000644}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETA99895.1}.
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DR EMBL; AYNT01000059; ETA99895.1; -; Genomic_DNA.
DR AlphaFoldDB; V7JNI2; -.
DR PATRIC; fig|1392000.4.peg.1123; -.
DR Proteomes; UP000018557; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd01887; IF2_eIF5B; 1.
DR CDD; cd03702; IF2_mtIF2_II; 1.
DR CDD; cd03692; mtIF2_IVc; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR HAMAP; MF_00100_B; IF_2_B; 1.
DR InterPro; IPR044145; IF2_II.
DR InterPro; IPR006847; IF2_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR000178; TF_IF2_bacterial-like.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00487; IF-2; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF5; TR-TYPE G DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF11987; IF-2; 1.
DR Pfam; PF04760; IF2_N; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 2.
DR PROSITE; PS51722; G_TR_2; 1.
DR PROSITE; PS01176; IF2; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000256|RuleBase:RU000644};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU000644}.
FT DOMAIN 139..310
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETA99895.1"
SQ SEQUENCE 643 AA; 69585 MW; BCA89151071E068E CRC64;
GQRGGAAGAF GRPGGAPRRG RKSKRQKRQE YDSMQAPVVG GVRLPHGNGE TIRLARGASL
SDFAEKIDAN PASLVQALFN LGEMVTATQS VGDETLELLG SEMNYNVQVV SPEDEDRELL
ESFDLTYGED EGTEEDLQTR PPVVTVMGHV DHGKTRLLDT IRKANVREAE AGGITQHIGA
YQVTVEHDGV ERPITFIDTP GHEAFTAMRA RGAKATDIAI LVVAADDGVM PQTVEAINHA
QAADVPIVVA VNKIDVEGAD PQKIRGQLTE YGLVPEEFGG DTMFVDISAK QGTNIDQLLE
AVLLTADAAL DLRANPDMEA QGVAIEAHLD RGRGPVATVL IQRGTLRVGD SIVAGDAYGR
VRRMVDEHGD DVEEALPSRP VQVIGFTSVP GAGDNLLVVD EDRIARQIAD KRSARKRNAL
AARSRKRISL EDLDSALKET SQLNLILKGD NAGTVEALEE ALMGIQIDDE VALRVIDRGV
GGITETNVNL ASASDAVIIG FNVRAEGKAT ELANREGVEI RYYSVIYQAI DEIEKALRGM
LKPIYEENQL GRAEIRAIFR SSKVGIIAGC MITSGVVRRN AKARLLRDNV VVSENLTINS
LRREKDDVTE VREGFECGMT LGYSDIKEGD VIESYELVQK ERT
//
