ID V8C8T9_9HELI Unreviewed; 391 AA.
AC V8C8T9;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=ATP-dependent DNA ligase family profile domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF2086_01277 {ECO:0000313|EMBL:ETD23472.1};
OS Helicobacter macacae MIT 99-5501.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=1357400 {ECO:0000313|EMBL:ETD23472.1, ECO:0000313|Proteomes:UP000018731};
RN [1] {ECO:0000313|EMBL:ETD23472.1, ECO:0000313|Proteomes:UP000018731}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MIT 99-5501 {ECO:0000313|EMBL:ETD23472.1,
RC ECO:0000313|Proteomes:UP000018731};
RX PubMed=25212613;
RA Shen Z., Sheh A., Young S.K., Abouelliel A., Ward D.V., Earl A.M.,
RA Fox J.G.;
RT "Draft genome sequences of six enterohepatic helicobacter species isolated
RT from humans and one from rhesus macaques.";
RL Genome Announc. 2:e00857-e00814(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0000256|ARBA:ARBA00001968};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETD23472.1}.
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DR EMBL; AZJI01000005; ETD23472.1; -; Genomic_DNA.
DR RefSeq; WP_023928019.1; NZ_KI669454.1.
DR AlphaFoldDB; V8C8T9; -.
DR STRING; 1357400.HMPREF2086_01277; -.
DR PATRIC; fig|1357400.3.peg.1712; -.
DR eggNOG; COG1793; Bacteria.
DR HOGENOM; CLU_021047_0_0_7; -.
DR OrthoDB; 9767858at2; -.
DR Proteomes; UP000018731; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd07896; Adenylation_kDNA_ligase_like; 1.
DR CDD; cd08041; OBF_kDNA_ligase_like; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR InterPro; IPR029319; DNA_ligase_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR PANTHER; PTHR47810; DNA LIGASE; 1.
DR PANTHER; PTHR47810:SF1; DNA LIGASE B; 1.
DR Pfam; PF01068; DNA_ligase_A_M; 1.
DR Pfam; PF14743; DNA_ligase_OB_2; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS00333; DNA_LIGASE_A2; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Reference proteome {ECO:0000313|Proteomes:UP000018731}.
FT DOMAIN 69..283
FT /note="ATP-dependent DNA ligase family profile"
FT /evidence="ECO:0000259|Pfam:PF01068"
FT DOMAIN 297..388
FT /note="DNA ligase OB-like"
FT /evidence="ECO:0000259|Pfam:PF14743"
FT REGION 204..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 391 AA; 43182 MW; 3FB286DB4D4002D9 CRC64;
MRIKNISFFA LFALFLVLFG FCYSNENSSG DFSENFGINS SADFSEDFDK STQVFALSNF
DKKLLENGSL QGYVVSEKLD GVRALWDGVV LKSRSGKAFS PPKCWVENLP DFALDGELFI
ARGKFEEVLS IVSKGDSQCE KCKCEEWSKV GYFIFDVPQA NQKLNAKNSA KSSADSSAES
SAKSYTLLER LALLESWIEN RANKTNKASQ AKTTKAKNSA DLDSAKASKN PILHIIPQES
VPSQEALQKK LKEVEKLGGE GLVIRKNSAP YERFRTTNAM KLKSYSDTEC VVVAHNQGKG
KFSHALGSLT CESLPLDFAT TKSAKNADST QPAPLTFPTH LRKIRFKIGS GFSDKDRAAP
PPIGTIITYK YYGLTKNGLP RFPVFLRVYS P
//
