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Database: UniProt
Entry: V8CCF0_9HELI
LinkDB: V8CCF0_9HELI
Original site: V8CCF0_9HELI 
ID   V8CCF0_9HELI            Unreviewed;       437 AA.
AC   V8CCF0;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   25-OCT-2017, entry version 30.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=HMPREF2086_00032 {ECO:0000313|EMBL:ETD24700.1};
OS   Helicobacter macacae MIT 99-5501.
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=1357400 {ECO:0000313|EMBL:ETD24700.1, ECO:0000313|Proteomes:UP000018731};
RN   [1] {ECO:0000313|EMBL:ETD24700.1, ECO:0000313|Proteomes:UP000018731}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MIT 99-5501 {ECO:0000313|EMBL:ETD24700.1,
RC   ECO:0000313|Proteomes:UP000018731};
RX   PubMed=25212613;
RA   Shen Z., Sheh A., Young S.K., Abouelliel A., Ward D.V., Earl A.M.,
RA   Fox J.G.;
RT   "Draft genome sequences of six enterohepatic helicobacter species
RT   isolated from humans and one from rhesus macaques.";
RL   Genome Announc. 2:e00857-14(2014).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ETD24700.1}.
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DR   EMBL; AZJI01000001; ETD24700.1; -; Genomic_DNA.
DR   RefSeq; WP_023926702.1; NZ_KI669454.1.
DR   EnsemblBacteria; ETD24700; ETD24700; HMPREF2086_00032.
DR   PATRIC; fig|1357400.3.peg.53; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000018731; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018731};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018731}.
FT   DOMAIN      130    257       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      339    410       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     138    145       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   437 AA;  49933 MW;  F6D51F2E71E2D2A9 CRC64;
     MIWEKVLSTL KEEVSPFDFE TYISLIKYDE NASKSNVAVL VVPNPYIESW IKSNYALKIA
     HIFEMQTKIK PEIRFSLSKE KPRKTHTKAK SGNMQVSYQS QYTFENFVVG DSNRHAYTVA
     QMVANTQAKA YNPVLFYGNT GLGKTHLLCS IGNFARGSGK TVIYLTTEEF MNDFQRHLNT
     VGMDAFRDIY RNCDYLLIDD IQFLGGKVSL QEEFFNTFEA LYKTNKQIVM TSDKLPKQIQ
     GLEERLRSRF ESGIKIDIQP PGVETRIQII AQKCVDNKIS MEKEVINYLA ENISENVRQI
     EGVIAKMRFH NAMTNQPISV EMAKSVLDEI LLENQEEITV EKIVRVIARE LNVKISEITS
     GSRVPKIVQA RHIVLYLIKD SASNMESMSS VASRLGLKNH ATVSKALTKI TKQIQEDENL
     KHLIVNLKNK IQNEKNL
//
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