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Database: UniProt
Entry: V8D3E4_9ACTN
LinkDB: V8D3E4_9ACTN
Original site: V8D3E4_9ACTN 
ID   V8D3E4_9ACTN            Unreviewed;       596 AA.
AC   V8D3E4;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   28-FEB-2018, entry version 17.
DE   SubName: Full=Thiamine pyrophosphate protein {ECO:0000313|EMBL:ETD34153.1};
GN   ORFNames=W823_03575 {ECO:0000313|EMBL:ETD34153.1};
OS   Williamsia sp. D3.
OC   Bacteria; Actinobacteria; Corynebacteriales; Williamsiaceae;
OC   Williamsia.
OX   NCBI_TaxID=1313067 {ECO:0000313|EMBL:ETD34153.1, ECO:0000313|Proteomes:UP000018666};
RN   [1] {ECO:0000313|EMBL:ETD34153.1, ECO:0000313|Proteomes:UP000018666}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D3 {ECO:0000313|EMBL:ETD34153.1,
RC   ECO:0000313|Proteomes:UP000018666};
RX   PubMed=24459282;
RA   Guerrero L.D., Makhalanyane T.P., Aislabie J.M., Cowan D.A.;
RT   "Draft Genome Sequence of Williamsia sp. Strain D3, Isolated From the
RT   Darwin Mountains, Antarctica.";
RL   Genome Announc. 2:e01230-13(2014).
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|RuleBase:RU362132}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ETD34153.1}.
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DR   EMBL; AYTE01000004; ETD34153.1; -; Genomic_DNA.
DR   RefSeq; WP_023954890.1; NZ_AYTE01000004.1.
DR   EnsemblBacteria; ETD34153; ETD34153; W823_03575.
DR   PATRIC; fig|1313067.3.peg.731; -.
DR   OrthoDB; POG091H02KO; -.
DR   Proteomes; UP000018666; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR000399; TPP-bd_CS.
DR   InterPro; IPR011766; TPP_enzyme-bd_C.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   PROSITE; PS00187; TPP_ENZYMES; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000018666};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018666};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN        4    173       TPP_enzyme_N. {ECO:0000259|Pfam:PF02776}.
FT   DOMAIN      198    328       TPP_enzyme_M. {ECO:0000259|Pfam:PF00205}.
FT   DOMAIN      388    543       TPP_enzyme_C. {ECO:0000259|Pfam:PF02775}.
SQ   SEQUENCE   596 AA;  64803 MW;  4CAA5209342FE0E7 CRC64;
     MSATVGDVVL ERLRQWNIGQ VFGYPGDGIN GLLAAWGRAD NSPQFVQSRH EEMSAFQAVG
     YAKFSGQIGV CAATSGPGGI HLLNGLYDAK LDHVPVLALV GQTERSAMGG SYQQEIDMLS
     LFKDVCSEYV QMCTVPEQIP NLIDRAIRIA LSEQAPTALI FPSDVFELEH TPPKHEFKHV
     PSSLGLSPGA PAADPAAVQQ AADLLNAGER VAILIGQGAR DCVGELTEVA DLLGAGCAKA
     LLGKDVLPDD LPWVTGSVGL LGTTASYQMM NDCDTLLTVG SNFPYSQFLP ELDQARAVQI
     DRSGKWIGMR YPYELNIVAD AKTTLRQLIP LLHRKEDRSW RETIESNVDQ WWTMAESQAT
     TDAEPTNPIR MFHELSERMP DNAIITADSG SAANWYARHL KFRGSVRGSL SGTLATMGPA
     VPYVIGAKWA HPDRPGIAFE GDGAMQMNGL AEMLTIARYW KQWTDPRLIV VVLHNNDLNQ
     VTWEQRGMEG TPKFVESQSL PDMNYAEFAR GIGLLGINVD TTEEIGPAWD AALAADRPAL
     LDVRCDPNVP PIPPHATLEQ AKSLGSALIK GDEDAWQVVK NTAKQKLAQV RPSDDS
//
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