ID V8N9H8_OPHHA Unreviewed; 433 AA.
AC V8N9H8;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Two pore calcium channel protein 1 {ECO:0000313|EMBL:ETE58217.1};
DE Flags: Fragment;
GN Name=TPCN1 {ECO:0000313|EMBL:ETE58217.1};
GN ORFNames=L345_16062 {ECO:0000313|EMBL:ETE58217.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE58217.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE58217.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE58217.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE58217.1}.
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DR EMBL; AZIM01007020; ETE58217.1; -; Genomic_DNA.
DR AlphaFoldDB; V8N9H8; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005765; C:lysosomal membrane; IEA:InterPro.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0022832; F:voltage-gated channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR028801; TPC1_animal.
DR PANTHER; PTHR46474; TWO PORE CALCIUM CHANNEL PROTEIN 1; 1.
DR PANTHER; PTHR46474:SF1; TWO PORE CHANNEL PROTEIN 1; 1.
DR Pfam; PF00520; Ion_trans; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 47..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 70..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 78..306
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 414..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 433
FT /evidence="ECO:0000313|EMBL:ETE58217.1"
SQ SEQUENCE 433 AA; 50765 MW; 099A3D9D9C772BFC CRC64;
MSSPATGEQR SPWDRGRRTW EMNYQEAAIY LQDPKALASY LFVHNHLFYL MELTTALLLL
LLSLCEAPAV AIFRLGIYVH ATLELFALTV VLFELSMKLR WLGCHTYIRH KRTMVKFVEA
VVVLVRQTSH LRITRALRCI FLVDCRYCGA VRRNLRQIFQ SLPPFIDILL LLLFFMVIFA
ILGFYLFSPN KSDPYFNTLE SSLVNLFVLL TTANTSTVAD AFRWVNRTIG NKTVVDQGYY
YLNNFDNILN SFVTLFELTV VNDWYIVMEG VTSETSHWSR LYFMIFYIVT MVVMTIIVAF
ILEAFVFRMN YARKNQDSEA EDSGIVFERE VSKEEIRGLA ETYGRQGDNL AASQLLKVVS
QMDRHRQAAM LFLGRRSRTK SDLSMKMYEE EIQEWYEEHS RREERELPWH EDEELLNQTF
HPPALRQRSQ TII
//
