ID   V8NAT6_OPHHA            Unreviewed;       177 AA.
AC   V8NAT6;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   22-FEB-2023, entry version 20.
DE   RecName: Full=Death domain-containing protein {ECO:0000259|PROSITE:PS50017};
DE   Flags: Fragment;
GN   ORFNames=L345_15514 {ECO:0000313|EMBL:ETE58763.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE58763.1, ECO:0000313|Proteomes:UP000018936};
RN   [1] {ECO:0000313|EMBL:ETE58763.1, ECO:0000313|Proteomes:UP000018936}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE58763.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA   Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT   snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETE58763.1}.
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DR   EMBL; AZIM01006317; ETE58763.1; -; Genomic_DNA.
DR   AlphaFoldDB; V8NAT6; -.
DR   Proteomes; UP000018936; Unassembled WGS sequence.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR022329; TNFR_25.
DR   PANTHER; PTHR47220; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 25; 1.
DR   PANTHER; PTHR47220:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 25; 1.
DR   Pfam; PF00531; Death; 1.
DR   SMART; SM00005; DEATH; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000018936}.
FT   DOMAIN          87..168
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          45..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..28
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ETE58763.1"
SQ   SEQUENCE   177 AA;  19624 MW;  3D7173D7ADB98B45 CRC64;
     MVVPDSIAPR TPRDEQCNMD EAAVDGAGDR KGAEISGLVG EAQVNLSGWD GRPAGDPRED
     GSPVSSLPET VMLMDKAPPP SRSLQQGRNL YTVINAVPVR RWKEFVRGLG LQDGEIELVE
     LEHSQFREQQ YEMLKRWCQQ RGASLVAILD TLEAMQLGGC AQELKEKLQV ELLWDKP
//