ID V8NCC0_OPHHA Unreviewed; 1380 AA.
AC V8NCC0;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=von Willebrand factor {ECO:0000256|ARBA:ARBA00016619};
DE Flags: Fragment;
GN Name=Vwf {ECO:0000313|EMBL:ETE59576.1};
GN ORFNames=L345_14693 {ECO:0000313|EMBL:ETE59576.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE59576.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE59576.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE59576.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SUBUNIT: Multimeric. Interacts with F8.
CC {ECO:0000256|ARBA:ARBA00025858}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE59576.1}.
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DR EMBL; AZIM01005470; ETE59576.1; -; Genomic_DNA.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR CDD; cd19941; TIL; 2.
DR CDD; cd01450; vWFA_subfamily_ECM; 2.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 3.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR032361; VWA_N2.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR001846; VWF_type-D.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR PANTHER; PTHR11339:SF361; VON WILLEBRAND FACTOR; 1.
DR Pfam; PF08742; C8; 2.
DR Pfam; PF01826; TIL; 2.
DR Pfam; PF00092; VWA; 4.
DR Pfam; PF16164; VWA_N2; 1.
DR Pfam; PF00094; VWD; 1.
DR SMART; SM00832; C8; 2.
DR SMART; SM00327; VWA; 3.
DR SUPFAM; SSF57567; Serine protease inhibitors; 2.
DR SUPFAM; SSF53300; vWA-like; 3.
DR PROSITE; PS50234; VWFA; 3.
DR PROSITE; PS51233; VWFD; 1.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 531..703
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 757..958
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 954..1168
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1303..1380
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE59576.1"
FT NON_TER 1380
FT /evidence="ECO:0000313|EMBL:ETE59576.1"
SQ SEQUENCE 1380 AA; 154158 MW; 9970DA9668B97CE5 CRC64;
MYDFAGDCSY LLAGDCEKRS FLLLGILEEN IYSFANSWGM SNQQKKCQRV MPPSYTCNIS
SVAAEKKNHR SSCFLSLFQE IMDCVVIPVL LFLQDFIKNC QLLRTSSVFS KCHHLVDPEK
FIGLCEEDMC RCAQDRNCHC PVFLEYARNC AQQGVILKGW PASSACIFAG MERGSATMSR
VQCADDRDAV CTRSVSVQLQ DENLTIKLKH GGGVSVNGQD IQIPFLQTRY AESSCSLLLS
PLFEPCHHEV SSSPYLKNCR YDVCSCSDGK DCLCTAVSAY AMACARKGVV IDWRKPDFCA
MSCPEGQLYQ QCGSPCNQTC RSLSHPDTDC HEFCTEGCFC PTGTYLDQQG DCVPRSQCSC
YYDGEIFQPD DVFSDHHTMW VKEVKMATAA TRLNAFMIWG LQNYLMGSET QSCENMNKVE
EEYQCEWRYN SCGPACPRTC QHMDPIACPV KCVEGCHPHC PAGKILDELS ESCIKLEECP
VCEAEGRRIS HGKKIILNSE NPQLCQSCPD EEDEEEEEEI TREYSCSKMM DLAILMDGSN
KLSESDFDEL KNFIISVMEK LHITQKRIRL AVLEYRTGSH IYLGLKDVKK STKMRKIVQN
IKYTGGDVAS ATEVLKYVLF HVFGKAPREN VARIAMLLMA SKDPKRIQGI FPLLKKKKII
VIPIGLGPHV STEQIGLIER QSPENRAFLM NSVLELRQRK DEIIDYFCGL VPEVSAVLTT
RRPIPTVPSV EARTYLPHGL TKVPSTEMSI SIEKVLEIVF LVEGSHNVGK SNFDTIKEFL
VRTIQELKVG EETIYISILQ YSFTITVEHS FQERQSKEFL IKKVREMKFQ GGNATNTGQA
LNFVTQQSFT TNRRREQVPH LVYMVTANPA TDIITRPPKD VHVIPIGIRP NADIQELQEL
SQPQAPIIIE GFNNLIKEGP DLVFKTCCSK KETCTKPMDV IFLLDGTSDV EEAQFEEMKR
FVKAFIEHAD VGHFSTQVAV LQYGKVNSLE ISWNAFQEEA NLLKKVDSIH QREKGPSKLV
CHLVVLGTAS VLLAGYACPV LFPGEAIDFM VQHAISEANG GRPNASKTAV VIVAGTSRDA
VEAAAYSARS NSKFVTLPLL LQCSDILETY LQLVGRVSLL PIGVGTKYNA EQLNALMGPS
AKDTIIKLQR FEDLSTMITL DDEFMKKLCT GKPHISSHSV PGDKWQLLDQ CYSVTCLPGG
HTELKSHRHL CEKMAKPTCH NNFPAVKVEE TCGCRWTDQS SSTGRNGMEQ QLGSGGPPEI
SDLLTHNHPA TWRVVIERCS LADFGPKVPH VMSKSKMLIE LGSTCMGSST RHIVTFDGLD
FKLTGNCSYT LFEDKEEGIE VTLHNGACSS VPKLNCMNAL EVTYQGFSVQ LYDNMTVRDQ
//
