ID V8NCV9_OPHHA Unreviewed; 899 AA.
AC V8NCV9;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Enhancer of mRNA-decapping protein 3 {ECO:0000256|ARBA:ARBA00015797};
DE AltName: Full=YjeF domain-containing protein 1 {ECO:0000256|ARBA:ARBA00032192};
GN Name=CYP1A5 {ECO:0000313|EMBL:ETE59417.1};
GN ORFNames=L345_14855 {ECO:0000313|EMBL:ETE59417.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE59417.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE59417.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE59417.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC {ECO:0000256|ARBA:ARBA00004201}.
CC -!- SIMILARITY: Belongs to the EDC3 family.
CC {ECO:0000256|ARBA:ARBA00006610}.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE59417.1}.
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DR EMBL; AZIM01005592; ETE59417.1; -; Genomic_DNA.
DR AlphaFoldDB; V8NCV9; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR GO; GO:0070330; F:aromatase activity; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0003729; F:mRNA binding; IEA:InterPro.
DR GO; GO:0031087; P:deadenylation-independent decapping of nuclear-transcribed mRNA; IEA:InterPro.
DR CDD; cd01737; LSm16_N; 1.
DR Gene3D; 2.30.30.100; -; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR Gene3D; 3.40.50.10260; YjeF N-terminal domain; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR008066; Cyt_P450_E_grp-I_CYP1.
DR InterPro; IPR036396; Cyt_P450_sf.
DR InterPro; IPR025762; DFDF.
DR InterPro; IPR019050; FDF_dom.
DR InterPro; IPR025609; Lsm14-like_N.
DR InterPro; IPR034107; Lsm16_N.
DR InterPro; IPR004443; YjeF_N_dom.
DR InterPro; IPR036652; YjeF_N_dom_sf.
DR PANTHER; PTHR13612:SF0; ENHANCER OF MRNA-DECAPPING PROTEIN 3; 1.
DR PANTHER; PTHR13612; UNCHARACTERIZED; 1.
DR Pfam; PF16598; Edc3_linker; 1.
DR Pfam; PF09532; FDF; 1.
DR Pfam; PF00067; p450; 2.
DR Pfam; PF03853; YjeF_N; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR01683; EP450ICYP1A.
DR PRINTS; PR00385; P450.
DR SMART; SM01199; FDF; 1.
DR SMART; SM01271; LSM14; 1.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR SUPFAM; SSF64153; YjeF N-terminal domain-like; 1.
DR PROSITE; PS51512; DFDF; 1.
DR PROSITE; PS51385; YJEF_N; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 617..653
FT /note="DFDF"
FT /evidence="ECO:0000259|PROSITE:PS51512"
FT DOMAIN 680..878
FT /note="YjeF N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51385"
FT REGION 576..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..605
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 899 AA; 101178 MW; 42DF0CC479FBA4A0 CRC64;
MTSVLARSQS LVSVPEILIS TAVFCLLLFL FKIRQRIPAG LRKLRGPRGY PFIGNILDLG
KNPHLALTGL SQKYGDVMLI HLGARPVVVL SGLETIKQAL VKQGGDFAGR PDLYSFQFIG
EGQTFTFGWN SEESWRIRRR LAQNALKTFA GSISPNSSTC LLEEHVSKEA EYLVTKFRDL
MKEKESFEPF QYVVISVVNV ICAMCFGKRY DHEDQELLNI VDINNDFGLV AASGNPADFF
PILRYLPSRS MEAFKDLNRR FNVLMKKLVE EHYEGFDKNN IRDITDSLIS FCQDKKTNLN
ANDALKDKNI VGIVNELFGA GFDTVTTALS WCLLYLVTYP EIQKRIQEEL AFMYEMFRHS
SFIPFTIPHC TTRDTALNGF YIPKDTCVFV NQWQVNHDPR QCIGQNIAKW EVFLFLTTLV
QKLEFTLSGT EMMDATPQYG LTMKYKKCEH FQGRVSAVNQ ASQTISLTRP FHNGVKCLVP
EVTFRAGDIT ELKILEIPGL GNNGQCGDFQ HPDLGILECP GGASQNGTGK LLKKPSSALQ
NIPRRTDVKA QEVALSPQLH PCSKSYVDRH MESLNPSKNF RRRHNSWSSS SRHPNQVTPK
KSGLKNGQMK SKDDECFGDD IEEIPDTDFD FEGNLALFDK AAVFEEIETY ERKGGTRSRG
TPSEKAAARY RHDENILDVS YELHKKLLSV AEKHGLTLER RLEMTGVCAS QMALSLLGGP
NRLNPKNIHQ RPTVALLCGP HVKGAQGISC GRHLSNHDVD VILFLPNFVK MLESITNELT
LFSKTEGQQV SKTPVDLVIN CLDCHENIFL RDQPWYKAAV DWANQNRAPV LSLDPPVNEM
EQEIDAKWSL ALGLPLPLGE RAGRLYLCDI GIPQKVFQEV GINYHSPFGC KFVIPLHST
//
