ID V8NFZ7_OPHHA Unreviewed; 1219 AA.
AC V8NFZ7;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Integrin alpha-11 {ECO:0000313|EMBL:ETE60901.1};
DE Flags: Fragment;
GN Name=Itga11 {ECO:0000313|EMBL:ETE60901.1};
GN ORFNames=L345_13352 {ECO:0000313|EMBL:ETE60901.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE60901.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE60901.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE60901.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE60901.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AZIM01004305; ETE60901.1; -; Genomic_DNA.
DR AlphaFoldDB; V8NFZ7; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd01469; vWA_integrins_alpha_subunit; 1.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 2.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF21; INTEGRIN ALPHA-11; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 5.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 5.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 1182..1206
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 114..174
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 187..368
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 378..429
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 489..550
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 551..609
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 613..673
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE60901.1"
SQ SEQUENCE 1219 AA; 135398 MW; D8AFC3A5DF8441F4 CRC64;
MSSQASLIFF SSNCHLCDRS PEFSSSEDEA KAPAVTATAQ QESQLPGTAA ICNSRSLGLS
GTAAIWDSLE TDWRLLVVGA PYEINGPQKT GDVYKCSVNG KTNSTCSKLN LGRVTLSNVS
ERKDNMRLGL SLTTNPKDNS FLACSPLWSH ECGSSYYTTG MCSRVNSNFR YSKSVAPALQ
KCQTYMDIII VLDGSNSIYP WAEVQNFLIR ILKKFYIGPG QIQVGVVQYG EDAVHEFHLN
DYRSVKDVVE AAKHIEQRGG TETRTAFGIE FARSEAFQKG GRKGAKKVMI VITDGESHDS
PDLEKAIEGS EKDNVTRYAV AVLGYYNRRG INPAAFLKEI KYIASDPDEK HFFNVSDEAA
LKDIVDALGE RIFSLEGTNK NEISFGLEMS QTGFSSHIVE DGILLGAVGA YDWNGAVLKE
TSSGKVVPHR ESYLQEFPDE LKNHGAYLGY TVTSVVSTRL ERIYVAGAPR FNHTGKVIVF
TMHTNRSLTI HQSLTGEQIG AYFGSEISSA DVDGDGITDI LLVGAPMYFS EGRERGRVYI
YSLKENQFVP NGALKDLPGY QNSRFGSCIA SVPDLNQDSY SDVVVGAPLE DEHQGALYIF
HGYRENLIRR YKQRIAAADL SPGFMYFGSS IHGNLDMNED KLVDLAVGSR GSAVLLWSRS
VVQINATLQF EPSKINIFTK DCVRNGKEAT CLSAFVCFTA VFLSAHFQAA HVALNYNLTI
DERRYFPRAH LDENGERLAH KAAALLAGQE HCDRMDFHVL DTADYVKPVT FSVDYALKSP
ETGPVMDDGW PTSLKVAVPF WNGCNEDEHC IPNLVLDAKT DVPTAMEYCR RVLRKSHSDC
STYTLSFDTS IFVIESARRR VAVEALLENR GENAYNTILN ISFSRNLQFA SLIQKDDPDI
NIECMSEEKH SNSKLCNVSF PFFRAKAKVA FRLDFEFKKS IFLQNLEIFL NASRSYKESV
PPLGDVAITL WPIGIVPFSK WISGSALYLS LNGSLVPSPR SSDSDEQETT KEDNSALLKF
QLKYETDLLF TRSSSQNYYE IEPNNSLQTY DRIGPPFNCT FKLQNLGLFP VDGIVIKITV
PVATRGGNRL LQLTGFHGPE NYSNSDVISI DCSVNLAANE EVSFLLYGNL WMRTLRMLKF
KTLRFIFNAA LQRGFRSAFV FREEDPSRQI AFEISKVEES HIPIWIIIGS TLGGFLLLAL
LVLALWKVSH SAATPPSPG
//
