ID V8NNB7_OPHHA Unreviewed; 540 AA.
AC V8NNB7;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Importin subunit alpha-6 {ECO:0000313|EMBL:ETE63555.1};
DE Flags: Fragment;
GN Name=KPNA5 {ECO:0000313|EMBL:ETE63555.1};
GN ORFNames=L345_10683 {ECO:0000313|EMBL:ETE63555.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE63555.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE63555.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE63555.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SIMILARITY: Belongs to the importin alpha family.
CC {ECO:0000256|ARBA:ARBA00010394}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE63555.1}.
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DR EMBL; AZIM01002687; ETE63555.1; -; Genomic_DNA.
DR AlphaFoldDB; V8NNB7; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032413; Arm_3.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR InterPro; IPR024931; Importin_alpha.
DR PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR PANTHER; PTHR23316:SF10; IMPORTIN SUBUNIT ALPHA-6; 1.
DR Pfam; PF00514; Arm; 8.
DR Pfam; PF16186; Arm_3; 1.
DR Pfam; PF01749; IBB; 1.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 8.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 2.
DR PROSITE; PS51214; IBB; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PROSITE-
KW ProRule:PRU00561}.
FT DOMAIN 5..68
FT /note="IBB"
FT /evidence="ECO:0000259|PROSITE:PS51214"
FT REPEAT 135..178
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 178..220
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE63555.1"
SQ SEQUENCE 540 AA; 60510 MW; F8BF46866B866799 CRC64;
MKILLFFIAD NMASPEKDNY RMKSYKNNAL NPQEMRRRRE EEGIQLRKQK REEQLFKRRN
VSLLSSEESM QESPIQDPDV SSTVPVLEED VITCDMVQMV FSDDPSQQLA ATQKFRKLLS
KEPNPPIDEV IQKPGVVERF VKFLEKNDNC TLQFEAAWAL TNIASGTFLH TKVVIETGAV
PIFIKLLNSE HEDVQEQAVW ALGNIAGDNA ECRDYVLSCG ILPPLLQLTT TRNAVWALSN
LCRGKNPPPD FSKVRPCLGV LSRLLFSSDS DVLADACWAL SYLSDGPNDK IQAVIDSGVC
RRLVELLMHN DYKVVSPALR AVGNIVTGDD IQTQVILNCS ALPCLLHLLS SPKESIRKEA
CWTVSNITAG NRAQIQAVID SNIFPVLIEI LQKAEFRTIK EAAWAITNAT SGGTPQQISY
LVALGCTKPL CDLLTVMDSK IVQVALNGLE NILRHGEQES KQNGIGVNPY CARIEEAYGL
DKIEILQSHE NQEIYQKAFD LIEHYFGVEE EDANIVPQVD ENEQQFVFQQ QEAPMEGFQL
//
