ID V8NQL5_OPHHA Unreviewed; 692 AA.
AC V8NQL5;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Double-stranded RNA-binding protein Staufen-like 1 {ECO:0000313|EMBL:ETE63842.1};
GN Name=STAU1 {ECO:0000313|EMBL:ETE63842.1};
GN ORFNames=L345_10389 {ECO:0000313|EMBL:ETE63842.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE63842.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE63842.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE63842.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE63842.1}.
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DR EMBL; AZIM01002538; ETE63842.1; -; Genomic_DNA.
DR AlphaFoldDB; V8NQL5; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd19879; DSRM_STAU1_rpt1; 1.
DR CDD; cd19881; DSRM_STAU1_rpt2; 1.
DR CDD; cd19883; DSRM_STAU1_rpt3; 1.
DR CDD; cd19887; DSRM_STAU1_rpt5; 1.
DR Gene3D; 3.30.160.20; -; 5.
DR Gene3D; 6.10.250.1360; -; 1.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR044475; STAU1_DSRM_3.
DR InterPro; IPR032478; Staufen_C.
DR PANTHER; PTHR46054:SF2; DOUBLE-STRANDED RNA-BINDING PROTEIN STAUFEN HOMOLOG 1; 1.
DR PANTHER; PTHR46054; MATERNAL EFFECT PROTEIN STAUFEN; 1.
DR Pfam; PF00035; dsrm; 4.
DR Pfam; PF16482; Staufen_C; 1.
DR SMART; SM00358; DSRM; 4.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 4.
DR PROSITE; PS50137; DS_RBD; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00266}.
FT DOMAIN 80..147
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 166..256
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 279..346
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 379..447
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 145..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..479
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 675..692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 692 AA; 75989 MW; E30ED64A6D85C957 CRC64;
MEINMSQVQI QNPTATLSSS QILSKNQSLA QPLSIPSPTS SLPSENAGRP IQNSALPSAS
VTSTSVAAVS SNMANPKEKT PMCLVNELAR FNKIQPEYKL LSEQGPAHSK VFTVQLTLGD
QHWEAEGTSI KKAQHAAAAK ALDGTRFPKP TARPSRNEGK NPDSVTPTVE LNALCMKLGK
KPMYKPIDPY TEMRSTYNYN MRGSAYPPRY FYPFPVGPWL YQVELSIGGQ QFHGKGRTRQ
AAKHDAAAKA LKILQNEPLP EKPEVINGRE PDDENLNKSE ISQVFEIALK RNLPVNFEVT
RESGPPHMKS FVTKVSVGEF MGEGEGKSKK ISKKNAAIAV LEELKKLPPL PTVEKMKPRI
KKKTKTIVKT SPEYGQGMNP ISRLAQIQQA KKEKEPEYML ITERGLPRRR EFVMQVKVGM
HTAEGMGTNK KVAKRNAAEN MLELLGFKVP QPQPPKPALK TEEKTPVKKP GDGRKVTFFE
PGCEETSSSN KEDEFRMPYL SHQQLPAGIL PMVPEVAQAV GVNQGHHTKE FSRAAPNPAK
ATVTAMIARE LLYGGTSPTA ETILKNSSLG HVPHGPLTRP SEQLDYLSGV QGIQVEYKDF
PKNNKNEFVS LINCSSQPPL ISHGIGKDVE SCHDMAALNI LKLLSELDQQ STEMPRTGNG
PMSVCVKQEM ESDPLLKPAS SNTLGQTLDT TA
//
