ID V8NQR2_OPHHA Unreviewed; 895 AA.
AC V8NQR2;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 22-FEB-2023, entry version 26.
DE SubName: Full=Sorting nexin-19 {ECO:0000313|EMBL:ETE63988.1};
DE Flags: Fragment;
GN Name=SNX19 {ECO:0000313|EMBL:ETE63988.1};
GN ORFNames=L345_10244 {ECO:0000313|EMBL:ETE63988.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE63988.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE63988.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE63988.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE63988.1}.
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DR EMBL; AZIM01002461; ETE63988.1; -; Genomic_DNA.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR CDD; cd06893; PX_SNX19; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR037909; SNX19_PX.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF31; SORTING NEXIN-19; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 86..259
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 520..650
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 332..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 665..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 666..684
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..737
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 739..755
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE63988.1"
SQ SEQUENCE 895 AA; 100421 MW; 65317343AEA95A38 CRC64;
MLRMPEQGVG LGDLASSRKL MALGALVGWL LVVHLLVNVW LLCILSGLLA LLGGWLGSQV
VVGTSHRIHL ERFLPLEGCP PNPEAERELE EEIRNIIRKI IRDFVSSWYR AVSREQNFEK
EVEKAMMGLA LGLQRRMLLV DKKALAQKVL LLAGCHLQAY KKVQETWKXE EADRLWRAYC
EFSEPHLAVQ SPAHQVDYAR RVVDLLLRVL VPEPHLESRT GRFVVVELVT CNVLMPVINK
MADPDWLNQL WVDLFSRNDT GTVEIVETSP EVLATYSSQP MVTGVLPPVL QPEMATEGDK
ALVRDPEPFN RNVVDSLEDF LVEGKEPVDR ALSTPMNEKD DGSMAAPLLH PGTLGPFFPS
GDFEVESPMS DAGKDPSSLI VVSAEELFAG SLLDLEGPLD VDPEDSFGEK DRCAEDMAEG
SLSEANLQAT SLGPCPDIHI EPVAEDTFAS LTALLEDPEK TFLRRPSYLV KELEPPGSLA
HGPQDLAQLP DLLSSSPTAP MGTFSFEPLS PDGPVIIQNL RITGTITARE HSGTGFHPYT
LYTVKYETTL DSDGTNSLQQ VAYHTVNRRY REFLNLQTRL EEKPDLRKFI KNIKGPKKLF
PDLPFGNMDT EKVEARKSLL ESFLKQLCAI PEITNSEEMQ EFLALNTDAR IAFVKKPFVS
PTEELSETEV DGKQPTDGKK SNKSKLKFTS GKMLNASEVL SLARMESFIQ NQEKLLEAMS
SEGPERECDE ESPSDLNPKP REVLQQTSDE DTNSGSETLL ADVVLDLLCL VMVDQWSWLW
SENMQKILHL LFGTLIQRWV EVQVDNLTCT QYWVQYLRLL QESIWPGGVL PEVPKPLRTE
EQKAETKEQA LKILMAILPD SLQEFLGINK CQQSWSLVLE SMQHPNINRH PKQRQ
//
