ID V8NR35_OPHHA Unreviewed; 538 AA.
AC V8NR35;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 {ECO:0000313|EMBL:ETE63992.1};
DE Flags: Fragment;
GN Name=NDST3 {ECO:0000313|EMBL:ETE63992.1};
GN ORFNames=L345_10241 {ECO:0000313|EMBL:ETE63992.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE63992.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE63992.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE63992.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE63992.1}.
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DR EMBL; AZIM01002458; ETE63992.1; -; Genomic_DNA.
DR AlphaFoldDB; V8NR35; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015016; F:[heparan sulfate]-glucosamine N-sulfotransferase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR InterPro; IPR021930; Heparan_SO4_deacetylase.
DR InterPro; IPR037359; NST/OST.
DR PANTHER; PTHR10605:SF29; BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE/N-SULFOTRANSFERASE 3; 1.
DR PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR Pfam; PF12062; HSNSD; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Transferase {ECO:0000313|EMBL:ETE63992.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 15..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 73..511
FT /note="Heparan sulphate-N-deacetylase"
FT /evidence="ECO:0000259|Pfam:PF12062"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE63992.1"
SQ SEQUENCE 538 AA; 61597 MW; 6D4BEBC95B44D822 CRC64;
MTFIVKLHRH FQRTVILLAT FCMVSIVISA YYLYSGYKQE NEVSEISSEV ECGDLPVLLS
PWKMIKASEP LRTDPVVLVF VESQYSVLGQ DIVMILESSR FQYHIEIASG KGDLPVLIDK
NKGKYVLIIY ENISKYMNMD SWNRGLLDKY CGEFSVGMIG FQKSNDNTLQ TFKLKGVPFQ
IHGNVGIKDC CINPHSPLLH LTKPSKLDKG PLPGTDWTVF HINHSAYQPV VFAKVKVPEN
LPPAAIKNVL HATVIHDLGL HDGIQRVLFG NNLNFWLHKL IFIDAVSFLT GKRLPLSLDR
YILVDIDDIF VGKEETRMKA SDVQVWYARK SMALLDTQNL LRAQITNFTF NLGFSGKFYH
TGTIEEDEGD DLLLGSVDEF WWFPHMWSHM QPHLFHNESS LVEQMILNKK FALEHGIPTD
MGYAVAPHHS GVYPVHVQLY DAWKKVWNIK ITSTEEYPHL KPARYRRGFI HKNIMVLPRQ
TCGLFTHTIF YKEYPGGPKE LNKSIHGGEL FFTVVLNPVS SLNYLNKIIA ERTLRNID
//