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Database: UniProt
Entry: V8NR35_OPHHA
LinkDB: V8NR35_OPHHA
Original site: V8NR35_OPHHA 
ID   V8NR35_OPHHA            Unreviewed;       538 AA.
AC   V8NR35;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 {ECO:0000313|EMBL:ETE63992.1};
DE   Flags: Fragment;
GN   Name=NDST3 {ECO:0000313|EMBL:ETE63992.1};
GN   ORFNames=L345_10241 {ECO:0000313|EMBL:ETE63992.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE63992.1, ECO:0000313|Proteomes:UP000018936};
RN   [1] {ECO:0000313|EMBL:ETE63992.1, ECO:0000313|Proteomes:UP000018936}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE63992.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA   Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT   snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETE63992.1}.
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DR   EMBL; AZIM01002458; ETE63992.1; -; Genomic_DNA.
DR   AlphaFoldDB; V8NR35; -.
DR   Proteomes; UP000018936; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015016; F:[heparan sulfate]-glucosamine N-sulfotransferase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   InterPro; IPR021930; Heparan_SO4_deacetylase.
DR   InterPro; IPR037359; NST/OST.
DR   PANTHER; PTHR10605:SF29; BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE/N-SULFOTRANSFERASE 3; 1.
DR   PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR   Pfam; PF12062; HSNSD; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW   Transferase {ECO:0000313|EMBL:ETE63992.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        15..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          73..511
FT                   /note="Heparan sulphate-N-deacetylase"
FT                   /evidence="ECO:0000259|Pfam:PF12062"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ETE63992.1"
SQ   SEQUENCE   538 AA;  61597 MW;  6D4BEBC95B44D822 CRC64;
     MTFIVKLHRH FQRTVILLAT FCMVSIVISA YYLYSGYKQE NEVSEISSEV ECGDLPVLLS
     PWKMIKASEP LRTDPVVLVF VESQYSVLGQ DIVMILESSR FQYHIEIASG KGDLPVLIDK
     NKGKYVLIIY ENISKYMNMD SWNRGLLDKY CGEFSVGMIG FQKSNDNTLQ TFKLKGVPFQ
     IHGNVGIKDC CINPHSPLLH LTKPSKLDKG PLPGTDWTVF HINHSAYQPV VFAKVKVPEN
     LPPAAIKNVL HATVIHDLGL HDGIQRVLFG NNLNFWLHKL IFIDAVSFLT GKRLPLSLDR
     YILVDIDDIF VGKEETRMKA SDVQVWYARK SMALLDTQNL LRAQITNFTF NLGFSGKFYH
     TGTIEEDEGD DLLLGSVDEF WWFPHMWSHM QPHLFHNESS LVEQMILNKK FALEHGIPTD
     MGYAVAPHHS GVYPVHVQLY DAWKKVWNIK ITSTEEYPHL KPARYRRGFI HKNIMVLPRQ
     TCGLFTHTIF YKEYPGGPKE LNKSIHGGEL FFTVVLNPVS SLNYLNKIIA ERTLRNID
//
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