ID V8NRY2_OPHHA Unreviewed; 473 AA.
AC V8NRY2;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 08-NOV-2023, entry version 20.
DE SubName: Full=Rho GTPase-activating protein 19 {ECO:0000313|EMBL:ETE64443.1};
DE Flags: Fragment;
GN Name=ARHGAP19 {ECO:0000313|EMBL:ETE64443.1};
GN ORFNames=L345_09788 {ECO:0000313|EMBL:ETE64443.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE64443.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE64443.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE64443.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE64443.1}.
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DR EMBL; AZIM01002255; ETE64443.1; -; Genomic_DNA.
DR AlphaFoldDB; V8NRY2; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04392; RhoGAP_ARHGAP19; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR047941; ARHGAP19_RhoGAP.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14963; RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED; 1.
DR PANTHER; PTHR14963:SF7; RHO GTPASE-ACTIVATING PROTEIN 19; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018936}.
FT DOMAIN 103..296
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 427..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..445
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE64443.1"
FT NON_TER 473
FT /evidence="ECO:0000313|EMBL:ETE64443.1"
SQ SEQUENCE 473 AA; 53555 MW; F4D58454D2E704A4 CRC64;
MERMLSRVSS GRINVACAVV LVRHQIIFNP DFFVEKLRHE KPEAFTELVV SNITRLIDLP
GAELAQLMGE EEPQLPGGPS ISSGFFRSLI SLKRKEKGVV FGAPLTEEGI AQISQLVEYL
HKNLRTEGLF RVPGNSTRQQ NLKEALNSGT EIDLDSGEFH SNDVATLLKM FLGELPEPLL
THKHFHAHLK ISDLMQFDDK GNKTNNPDKE RQIEALQLLF LILPAANRNL LKLLLDLLYQ
TAKKQDRNKM SAHNLALMFA PHILWPRNVT ASDLQENINK LNNGMAFMIK HSQKLFKAPV
YIREYARIHY LDSRTHASKD DLDLPMPQNF KDIQLLKFKN RGLLDPSAHL EDTQHHTEEA
LKELFCHVHN MPDSAKKKKL IQQKHPEALT PQAAISTQIQ KRARTRSFSG LIKRKVLGSQ
VILDKKKSDT VTESAGTKDS KHSSKENISM TPASSPAINV IRAKLKSLEQ RKE
//
