ID V8NTW4_OPHHA Unreviewed; 1844 AA.
AC V8NTW4;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Sodium channel protein type 8 subunit alpha {ECO:0000313|EMBL:ETE65133.1};
DE Flags: Fragment;
GN Name=SCN8A {ECO:0000313|EMBL:ETE65133.1};
GN ORFNames=L345_09096 {ECO:0000313|EMBL:ETE65133.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE65133.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE65133.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE65133.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE65133.1}.
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DR EMBL; AZIM01001981; ETE65133.1; -; Genomic_DNA.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR008054; Na_channel_a8su.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF23; SODIUM CHANNEL PROTEIN TYPE 8 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR PRINTS; PR01667; NACHANNEL8.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 4: Predicted;
KW Ion channel {ECO:0000313|EMBL:ETE65133.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 111..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 331..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 370..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 746..764
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 776..794
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 814..835
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 856..884
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 943..969
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1189..1207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1228..1247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1259..1282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1303..1331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1428..1454
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1512..1530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1542..1560
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1572..1592
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1629..1657
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1732..1755
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 116..403
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 527..692
FT /note="Voltage-gated Na+ ion channel cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF11933"
FT DOMAIN 745..976
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 983..1182
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1187..1463
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1511..1764
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 429..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 557..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1101..1126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1791..1844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..57
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1107..1121
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1799..1813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1815..1844
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE65133.1"
SQ SEQUENCE 1844 AA; 210135 MW; FBB51CFC054FA7C7 CRC64;
MAGRLLAPPG PDSFRPFTPE SLANIEKRIA EEKKKKRPKQ DSSHRDDDEE NKPKPNSDLE
AGKSLPFIYG DIPKGLVAVP LEDFDPFYMT QKTFVVLNRG KTLFRFSATP ALYILIFSMI
IMCTILTNCV FMTFSNPPEW SKQVEYTFTG IYTFESLVKI IARGFCIDGF TFLRDAWNWL
DFSVIMMAYV TEFVDLGNVS ALRTFRVLRA LKTISVIPGL KTIVGALIQS VKKLSDVMIL
TVFCLSVFAL IGLQLFMGNL RNKCVIWPID LNETYLENGT KGFDWEEYSN NVSNFYTIPG
FLDPLLCGNS SDAGQCPEGY TCMKAGRNPN YGYTSFDTFS WAFLALFRLM TQDFWENLYQ
LTLRAAGKTY MIFFVLVIFV GSFYLVNLIL AVVAMAYEEQ NQATLEEAEQ KEAEFKAMLE
QLKKQQEEAQ AAAMATSAGT VSEDAVEEDG GGRMSHTSSE FSKLSSKSAK ERRNRRKKRK
EKELSEGEEK GDIEKVFKSE SEDGMRRKVF RLPDNRLGRK LSIMNQSLLS IPGSPYLSRH
NSKSSIFSFK RGFRDPGSEN EFADDEHSTV EESEGRRDSL FIPIRGYDRK SSYSGYSGYS
QGSRSSRIFP SIRRNVKRNS TVDCNGVVSL IGGPTSNIPS GRLLPEVKID KAATDNSATT
EVEIKKKATG SLLVSMDQLN ASYGRKDRTN SIMTVITNTL VEELEESQRK CPPCWYKFAN
TFLIWECHPH WVKLKEIVNL IVMDPFVDLA ITICIVLNTL FMAMEHHPMT PQFEHVLAVG
NLVFTGIFTA EMFLKLIAMD PYYYFQEGWN IFDGFIVSLS LLELMLADVE GLSVLRSFRL
LRVFKLAKSW PTLNMLIKII GNSVGALGNL TLVLAIIVFI FAVVGMQLFG KNYKECVCKI
NPDCDLPRWH MHDFFHSFLI VFRVLCGEWI ETMWDCMEVA GQAMCLIVFM MVMVIGNLVV
LNLFLALLLS SFSADNLAAS DDDGEMNNLQ ISVIRIKKGI AWTKIKVHDF VQTHFKQREA
DEIKPLDELY DKKMNCIANH TGADINREID YQKNGNGTTS GIGSSVEKYI IDEDHMSFIN
NPHLTVRVPI AVGESDFENL NTEDFSSDTD GSKEKLDDTS SSEGSTIDIK PEAEEVPVEA
PEEYLDPDAC FTEGCVQKFK CCQVSIEEGL GKSWWNLRKT CFLIVEHNWF ETFIIFMILL
SSGALAFEDI YIEQRKTIRT VLEYADKVFT YIFILEMLLK WCAYGFVKFF TNAWCWLDFL
IVAVSLVSLI ANALGYSELG AIKSLRTLRA LRPLRALSRF EGMRVVVNAL VGAIPSIMNV
LLVCLIFWLI FSIMGVNLFA GKYHYCFNQT AEHRFDIEEV NNKTECEKLM DPNGTEIRWK
NVKINFDNVG AGYLALLQIA TFKGWMDIMY AAVDSRKQEE QPKYEDNIYM YIYFVIFIIF
GSFFTLNLFI GVIIDNFNQQ KKKIGQDIFM TEEQKKYYNA MKKLGSKKPQ KPIPRPLNRI
QGAVFDFVTQ QAFDILIMLL ICLNMVTMMV ETDTQSKQME DILYWINFVF VIFFTCECVL
KMFALRHYYF TIGWNIFDFV VVILSIVGMF LAEIIEKYFV SPTLFRVIRL ARIGRILRLI
KGAKGIRTLL FALMMSLPAL FNIGLLLFLV MFIFSIFGMS NFAYVKHEAG IDDMFNFETF
GNSMICLFQI TTSAGWDGLL LPILNRPPDC DLEKEHPGSG FKGDCGNPSV GIFFFVSYII
ISFLIVVNMY IAIILENFSV ATEEMVIQRA YRVRLARRGF VCRKNVSNRI ENGGTNREKK
EGTPSTASLP SYDSVTKPEK EKQRAEEGRR ERAKRQKDVR ESKC
//
