ID V8NWW4_OPHHA Unreviewed; 921 AA.
AC V8NWW4;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Toll-like receptor 3 {ECO:0000313|EMBL:ETE66168.1};
DE Flags: Fragment;
GN Name=TLR3 {ECO:0000313|EMBL:ETE66168.1};
GN ORFNames=L345_08057 {ECO:0000313|EMBL:ETE66168.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE66168.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE66168.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE66168.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE66168.1}.
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DR EMBL; AZIM01001641; ETE66168.1; -; Genomic_DNA.
DR AlphaFoldDB; V8NWW4; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR041015; TLR3_TMD.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF524; TOLL-LIKE RECEPTOR 3; 1.
DR Pfam; PF13855; LRR_8; 5.
DR Pfam; PF01582; TIR; 1.
DR Pfam; PF17968; Tlr3_TMD; 1.
DR SMART; SM00365; LRR_SD22; 8.
DR SMART; SM00369; LRR_TYP; 15.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:ETE66168.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 720..741
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 770..914
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE66168.1"
SQ SEQUENCE 921 AA; 105455 MW; CFC754CC0BCFF18B CRC64;
SSSVHLLSVR KQDVLLLLGP GPQSNQINCK SIIAETSGKR IKIIAGREKK MRKLLKCWTY
LPFILCTIPT NCGSTQNICK ITDKMADCSH LKLSQIPSNL PADITALDIS HNQLRTLLPK
NLTKYNQLVY LNVGFNSISK LEMHLCLSLP LLEVLRLEHN QLRTLHGEVF TSCTNLRELN
LGFNILNTKN DPFKNLKNLA FLDVSHNHLS STKLGSQQQL ENLQELVMSQ NQITELNKED
LYFLGCFHAI ENIYGLDLNN APLGPDGTEK LCLELSGTKI QNLSMSKVQL SRISSLTFSG
MSKTNLSILN LSNNYLSVIE NASFIYFSNL KELNLMNNNI TKLFSHSLYG LHNLNYLNLE
NSHVRIINLA FQWLAHLNDL IMDGNRFLEI TPYTFKGLEN LKNLSLCQCN INSITNMTFA
SLANSSLQFL NLTKAGIISI KPKAFSWLRQ LKMLDLGLND IKQKLTGQEF QGLSNIETLY
LSYNYQLNLT SESFTLIPSL RKLRMRKVRC SNLAITPSPF RKLKNLTILD MGNNNIANIK
DDIFDGLHQL EILDLQHNNL ARLWKHTNPD GPVLFLKDLH NLRLLDLESN GFDEIPHKGF
YGLSLLRSLN LDSNLLNLLP KSVFDDLTSL SFLSLQKNMI TAIDEKVFGA VFKHLKVLNM
ASNPFDCTCD SIAWFVSWLN RNKTYVSNLN NYQCNTPPKY HSNLVAQFDT SICDNAPFKL
VFILCTTAVS LLIFIALLVH FEGWRIKFMY SVAVNRVLGI KEIDRQQQQF EYDAYIIHAK
KDMNWVSKNF ITLEENNQPA IRFCLEERDF EAGISEFEAI VNSIQRSRKI VFIVTKHLLN
DPWCKRFKVY HAIQQAIEQS RDSIILIFRH DVPDYKLKNA LCLRRAMFKS HCILEWPVQK
ERLDAFYQQL KSALQSNSRI I
//
