ID   V8NWX0_OPHHA            Unreviewed;      1241 AA.
AC   V8NWX0;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=Nesprin-2 {ECO:0000313|EMBL:ETE66047.1};
DE   Flags: Fragment;
GN   Name=SYNE2 {ECO:0000313|EMBL:ETE66047.1};
GN   ORFNames=L345_08178 {ECO:0000313|EMBL:ETE66047.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE66047.1, ECO:0000313|Proteomes:UP000018936};
RN   [1] {ECO:0000313|EMBL:ETE66047.1, ECO:0000313|Proteomes:UP000018936}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE66047.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA   Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT   snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETE66047.1}.
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DR   EMBL; AZIM01001675; ETE66047.1; -; Genomic_DNA.
DR   AlphaFoldDB; V8NWX0; -.
DR   Proteomes; UP000018936; Unassembled WGS sequence.
DR   GO; GO:0005635; C:nuclear envelope; IEA:UniProt.
DR   CDD; cd00176; SPEC; 3.
DR   Gene3D; 1.20.58.60; -; 4.
DR   InterPro; IPR039906; Anc-1/SYNE1/2-like.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   InterPro; IPR002017; Spectrin_repeat.
DR   PANTHER; PTHR21524; SPECTRIN REPEAT CONTAINING NUCLEAR ENVELOPE PROTEIN 2; 1.
DR   PANTHER; PTHR21524:SF6; SPECTRIN REPEAT-CONTAINING NUCLEAR ENVELOPE PROTEIN 2; 1.
DR   Pfam; PF00435; Spectrin; 2.
DR   SMART; SM00150; SPEC; 8.
DR   SUPFAM; SSF46966; Spectrin repeat; 8.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018936}.
FT   REGION          722..805
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          2..29
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1096..1125
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        722..746
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1241
FT                   /evidence="ECO:0000313|EMBL:ETE66047.1"
SQ   SEQUENCE   1241 AA;  144761 MW;  428A49D84CBAE1A9 CRC64;
     MKESLKENMP TTLEKLQEQQ KEYEILQTEI SINQQIFSCL VSKALNMLES GEAENRTEFI
     SRLTLLKEQW QSAVRMAHRK KIDIDSLVKQ WQKFTTLLQD LTKFLMDTNS YIAAVKSQEK
     YRLDQIRNLN HKFKNKEILQ KRWQTRYSLI LDTGEKLLGM VVPEAKAAMQ LEMNKLQANW
     DNTQLQLEKI TRQFQGTIQT WENCESQVKD LGHVLLELKG SINKPLPIEH DALPATLEQV
     KVLEKSLTNW SQNAKELDAQ KMKLAQFFLP EDVMVLREQI ERLHSQWEEL CLRVSLHKQD
     IEERLNAWIV FNEKNKELCT WLMQMEEKVP QSADISIEDM IDKLQKDYME EINLFNESQL
     VHFKQMGNQL IKSSNQSRGA EIEEKLNKIN DRWQHLFDII RGRVKKLKDT FAFIQQLDKN
     MSHLHTWLAR IESELSKPIV YDICDDQEIQ RRLAEQQDLQ RDIEQHTAGV ESVFNICEIL
     LHDSDACANE TECDSIQQTT RSLERRWRNI CAMSIERRMK IEATWRLWQK FLEDYSRFEV
     WLKTAEKTAA YPNSSEILYV TAKEELKKFE AFQRQIHERL TQLELINKQY RRLARENRTD
     SANKLKQMHF TNQWEEFMGT KDNIILVWLT EMDLQLTNVE HFSKSDFDDK MRQLNGFQRE
     IMLNTSKIDQ LIASGLYLIQ RSEPEDAIIL EEELEEFRSY CQEVFGRVAR FHQRLISWHP
     GLEDEKESSE NEADSDHARG MEADPWPKKT VQEGPPSQQS LCHLIPTAGG PERSGCETPV
     SVDSIPLEWD HTGDVGGSSS PEDEEEDSFF SALSDVEITE HPEAYLKMTT KALKAASGKS
     AETHIWHPSE HPVCRKHSYN QEEMVRSVLS NNEDSSTSYK PGNVIQLSTT SVDDIKDISR
     ILPSKDSQNS QNFISVSGIE KQPGTIERWE LLQVQDLSNK LRMKQTWQQW QQLNADLTNI
     DIWLDKMEEE MEGLQEEEPQ PVNSIQAIDQ RVKKLKDMFK AYNNYKALVL SVNLTSKDFK
     QTDSTGCKEL QNRLRRVNLR WEKANILLEN WKKNLQKALI HCQDFHEQNQ KLLLWLAAAE
     TRRHQAQVKE PNADPHRIQE SQKELMQLEK ELLERQLQVN TLQEIAAYLL VKPDGEKYTE
     ANEKVHVIGK KLKQLLEGVS CDLKGSQGRQ VGWTAYSKSD YSRSNFGEIT EDVSTFQVNG
     EELDSGTYHQ LSEKSTVSKN KASCLVDEKK ILQSNTSSNV R
//