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Database: UniProt
Entry: V8P383_OPHHA
LinkDB: V8P383_OPHHA
Original site: V8P383_OPHHA 
ID   V8P383_OPHHA            Unreviewed;       609 AA.
AC   V8P383;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   25-OCT-2017, entry version 22.
DE   SubName: Full=Transient receptor potential cation channel subfamily V member 6 {ECO:0000313|EMBL:ETE68795.1};
DE   Flags: Fragment;
GN   Name=Trpv6 {ECO:0000313|EMBL:ETE68795.1};
GN   ORFNames=L345_05408 {ECO:0000313|EMBL:ETE68795.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE68795.1, ECO:0000313|Proteomes:UP000018936};
RN   [1] {ECO:0000313|EMBL:ETE68795.1, ECO:0000313|Proteomes:UP000018936}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE68795.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W.,
RA   Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M.,
RA   Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation
RT   in the snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ETE68795.1}.
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DR   EMBL; AZIM01000933; ETE68795.1; -; Genomic_DNA.
DR   ProteinModelPortal; V8P383; -.
DR   Proteomes; UP000018936; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR   CDD; cd00204; ANK; 2.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR024862; TRPV.
DR   InterPro; IPR008344; TRPV5/TRPV6.
DR   PANTHER; PTHR10582; PTHR10582; 2.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   PRINTS; PR01765; ECACCHANNEL.
DR   SMART; SM00248; ANK; 4.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00933366};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018936};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:ETE68795.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    305    329       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    363    381       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    402    422       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    428    446       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    467    488       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    530    552       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       67    239       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   REPEAT      101    128       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      139    171       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:ETE68795.1}.
SQ   SEQUENCE   609 AA;  68801 MW;  9F8C52022EB2D74A CRC64;
     MEGGLKKPHQ RALIVLKQEG IGCQESVPGC LQFSLSSCLE PVPTAFPHFR AFVGTEFREL
     HESGLRIWES PLLLAAKEND LSAIQKLIAS HTCDLHERGA VGETALHVAA LYNNLEAAQL
     LINAAPELVN EPVTSELYAG EHILSFAACS GSEAIVQLLI ENGAKIRVQD SLGNSVFHIL
     TLQPNKASAC QIYDLLLCYD KKEKGQGDPD AVLNYEGFTP FKLAGVEGNT VLFNHLMQRR
     KHVLWTFGSL TSTLYDLTEI DSWGDDQSLL ELIVTTKKRE ARRILDLTPV NELVSLKWNK
     YGRPYFCILA LFYVLYMICF TMCCVYRPLK ERSFNKTNER DNTIYVQKLL QESYITSEDN
     HRLVGELITV VGAIVILILE IPDIFRFGIT KYFGQTILGG PFHAIIIVYA CMILLTMVMR
     LTSTNGEVVP MSLALVLGWC NIMYFARGFQ MLGPFTIMIQ KMIFGDLLRF CWLMAVVILG
     FASAFYIIFQ TEDPDELGHF YSYPMALYST FQLFLTIIDG PANYEVDLPF MYGITYSAFA
     IIAALLMLNL LIAMMGDTHW RVAHERDELW RAQVVSTTIM LERKLPQCLW PRSGICGKEY
     GLGNQRYLR
//
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