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Database: UniProt
Entry: V8P4R2_OPHHA
LinkDB: V8P4R2_OPHHA
Original site: V8P4R2_OPHHA 
ID   V8P4R2_OPHHA            Unreviewed;       478 AA.
AC   V8P4R2;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   25-OCT-2017, entry version 18.
DE   SubName: Full=Potassium voltage-gated channel subfamily H member 8 {ECO:0000313|EMBL:ETE68983.1};
DE   Flags: Fragment;
GN   Name=KCNH8 {ECO:0000313|EMBL:ETE68983.1};
GN   ORFNames=L345_05220 {ECO:0000313|EMBL:ETE68983.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE68983.1, ECO:0000313|Proteomes:UP000018936};
RN   [1] {ECO:0000313|EMBL:ETE68983.1, ECO:0000313|Proteomes:UP000018936}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE68983.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W.,
RA   Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M.,
RA   Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation
RT   in the snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ETE68983.1}.
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DR   EMBL; AZIM01000875; ETE68983.1; -; Genomic_DNA.
DR   Proteomes; UP000018936; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   CDD; cd00130; PAS; 1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR003950; K_chnl_volt-dep_ELK.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   PRINTS; PR01465; ELKCHANNEL.
DR   SMART; SM00086; PAC; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   TIGRFAMs; TIGR00229; sensory_box; 1.
DR   PROSITE; PS50113; PAC; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000018936};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    220    245       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    265    284       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    323    341       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    362    385       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    426    444       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    456    475       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      101    153       PAC. {ECO:0000259|PROSITE:PS50113}.
FT   NON_TER     478    478       {ECO:0000313|EMBL:ETE68983.1}.
SQ   SEQUENCE   478 AA;  54413 MW;  DD3DB7D1190B3D68 CRC64;
     MLDALQKQDS AQKLVLLNSI PHLIEEPSPK SQFDSNFILA NAQVAKGFPI VYCSDGFCEL
     SGFARTEVMQ KSCSCKFLYG AETNEQMILQ IEKSLEEKIE FKGEIMFYKK NRSSFWCLLD
     VVPIKNEKGD VVLFLSSFKD ITDTKIKISL EEKKDEKFKG RGRAGSHFDS ARRRSRAVLY
     HISGHLQRRE KNKLKINNNV FIDKPAFPEY KVSDAKKSKF ILLHFSTFKA GWDWLILLAT
     FYVAVTVPYN VCFIGNDDLS TTRSTTVSDI AVEILFIIDI ILNFRTTYVS KSGQVIFEAR
     SICIHYVTTW FIIDLIAALP FDLLYAFNVN VVSIVHLLKT VRLLRLLRLL QKLDRYSQHS
     TIVLTLLMSM FALLAHWMAC IWYVIGKKEM EKKPLTWDIG WLHELGKRLE SPYFGNNTSG
     GPSLRSAYIA ALYFTLSSLT SVGFGNVSAN TDAEKIFSIC TMLIGADVLQ MVPLSHKN
//
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