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Database: UniProt
Entry: V8P7J5_OPHHA
LinkDB: V8P7J5_OPHHA
Original site: V8P7J5_OPHHA 
ID   V8P7J5_OPHHA            Unreviewed;      1867 AA.
AC   V8P7J5;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   12-APR-2017, entry version 21.
DE   SubName: Full=Sodium channel protein type 2 subunit alpha {ECO:0000313|EMBL:ETE69867.1};
DE   Flags: Fragment;
GN   Name=SCN2A {ECO:0000313|EMBL:ETE69867.1};
GN   ORFNames=L345_04326 {ECO:0000313|EMBL:ETE69867.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE69867.1, ECO:0000313|Proteomes:UP000018936};
RN   [1] {ECO:0000313|EMBL:ETE69867.1, ECO:0000313|Proteomes:UP000018936}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE69867.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W.,
RA   Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M.,
RA   Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation
RT   in the snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ETE69867.1}.
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DR   EMBL; AZIM01000673; ETE69867.1; -; Genomic_DNA.
DR   Proteomes; UP000018936; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018936};
KW   Ion channel {ECO:0000313|EMBL:ETE69867.1};
KW   Ion transport {ECO:0000313|EMBL:ETE69867.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000313|EMBL:ETE69867.1}.
FT   TRANSMEM    285    306       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    312    332       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    462    489       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    746    770       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    782    803       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    865    893       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    955    978       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1206   1224       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1245   1267       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1273   1293       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1322   1348       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1447   1470       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1528   1546       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1558   1576       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1588   1608       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1645   1673       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1749   1772       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      219    496       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      501    704       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      755    983       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      992   1199       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1204   1478       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1527   1778       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      486    531       {ECO:0000256|SAM:Coils}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:ETE69867.1}.
SQ   SEQUENCE   1867 AA;  212398 MW;  C3966AE29678557E CRC64;
     MEKREASSFS LRLGCTDASK EEQGKFKAML DYPAELRARA KSNFNVQDEK MAQTLLVPPG
     PDSFRFFTRE SLAAIEKRCT EEKAKRPKQE HTDNDDESGP KPNSDLEAGK TLPFIYGDIP
     PGMVSEPLED LDPYYSNKKT FIVLNRGKAI FRFSATSALY ILTPFNPLRK IAIKILGVTP
     LNIWEQLFLK FYLLLNIKSV SKLRSVWNST FFNFHLPASR YTFTGIYTFE SLIKILARGF
     CLEGFTFLRD PWNWLDFSVI LMAYVTEFVN LGNVSALRTF RVLRALKTIS VIPGLKTIVG
     ALIQSVKKLS DVMILTVFCL SVFALIGLQL FMGNLRHKCL LWPLDNATFE GNITSHFNST
     EGENDTFVNM TVTTFNWEEY IEDESHFYVL EGQRDALLCG NSSDAGQCPE GYVCIKAGRN
     PNYGYTSFDT FSWAFLSLFR LMTQDFWENL YQLTLRAAGK TYMIFFVLVI FLGSFYLINL
     ILAVVAMAYE EQNQATMEEA EQKEAEFQQM LEQLKKQQEE AQITIREATH LLITPNNNWF
     GLCSVLPPLQ SLLSFRGSLF SPRRNSRTSI FSFRGRAKDI GSENDFADDE HSTLEDNESR
     RDSLFVPNRQ TSERRNSTTS QMSLSSKMVP VLPANGKMHS TVDCNGVVSL MGGPPALPSP
     TGQFLPEGTT TETEIRKRRL SSYQISMELM EESAARQRAM SIASILTNTM EELEESRQKC
     PPCWYRFANV FLIWDCWSPW LKVKHIVNLI VMDPFVDLAI TICIVLNTLF MAMEHYPMTS
     DFYQVLSVGN LVFTGIFTAE MILKIIAMDP YYYFQEGWNI FDGIIVSLSL MELGLANVEG
     LSVLRSFRLL RVFKLAKSWP TLNMLIKIIG NSVGALGNLT LVLAIIVFIF AVVGMQLFGK
     SYKECVCKIA EDCELPRWHM NDFFHSFLIV FRVLCGEWIE TMWDCMEVAG QTMCLIVFML
     VMVIGNLVVL NLFLALLLSS FSSDNLAATD DDNETNNLQI AVARIQKGID YIKKKLGEIV
     QKSTVRKQKA IDDIKVFEEL NHKKDVYISN HTMVEITKDV NYLRDGNGTT SGLGTGSSVE
     KYIIDENDYM SFINNPGLTV TVPIAVGESD FENINTEEFS SESDLEGSKE KINATSSSEG
     STVDVALPGE GEQAEIEPEE ALEPEACFTE GCIQKFPCCQ VSIEDGKGKI WWNFRKTCYS
     IVEHNWFETF IVFMILLSSG ALAFEDIYVE QRKTIKTMLE YADKVFTYIF ILEMLLKWVA
     YGFQIYFTNA WCWLDFLIVD VSLVSLIANA LGYSELGAIK SLRTLRALRP LRALSRFEGM
     RVVVNALIGA IPSIMNVLLV CLIFWLIFSI MGVNLFAGKF YHCVNTTTGE MFNISDVNNK
     TECDELIHNN QQARWKNVKV NFDNVGAGYL ALLQVATFKG WMDIMYAAVD SRDVEEQPYY
     EDNLYMYLYF VIFIIFGSFF TLNLFIGVII DNFNQQKKKI RQDIFMTEEQ KKYYNAMKKL
     GSKKPQKPIP RPGNKFQGLV FDFVTKQAFD ISIMILICLN MVTMMVETDD QSKEMEIILS
     RINLVFIILF TGECILKLIS LRHYYFTIGW NIFDFVVVIL SIVGMFLAEI IEKYFVSPTL
     FRVIRLARIG RILRLIKGAK GIRTLLFALM MSLPALFNIG LLLFLVMFIY AIFGMSNFAY
     VKREVGIDDL FNFETFGNSM LCLFQITTSA GWDGLLAPIL NSGPPDCDPE IDHPGSSVKG
     DCGNPSVGIF FFVSYIIISF LVVVNMYIAV ILENFSRAFR RFLLKQKVKK VTSMYNKEKC
     RDGEILPIKD VTSDRFNGNS SPEKTDESSS TTSPPSYDSV TKPNKEKYEK GKTDRDFKGK
     DIKISKK
//
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