ID V8P890_OPHHA Unreviewed; 1173 AA.
AC V8P890;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 22-FEB-2023, entry version 28.
DE SubName: Full=Pleckstrin-likey domain-containing family A member 5 {ECO:0000313|EMBL:ETE70233.1};
DE Flags: Fragment;
GN Name=PLEKHA5 {ECO:0000313|EMBL:ETE70233.1};
GN ORFNames=L345_03961 {ECO:0000313|EMBL:ETE70233.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE70233.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE70233.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE70233.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE70233.1}.
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DR EMBL; AZIM01000584; ETE70233.1; -; Genomic_DNA.
DR AlphaFoldDB; V8P890; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR CDD; cd13248; PH_PEPP1_2_3; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR040392; PKHA4-7_PH.
DR PANTHER; PTHR12752; PHOSPHOINOSITOL 3-PHOSPHATE-BINDING PROTEIN; 1.
DR PANTHER; PTHR12752:SF3; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 5; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018936}.
FT DOMAIN 104..219
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 74..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 889..934
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1039..1076
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1090..1161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1039..1061
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1100..1121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1122..1139
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1147..1161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE70233.1"
SQ SEQUENCE 1173 AA; 133657 MW; A959CABCADD07527 CRC64;
MGLISCVNLE CLYPSLGCGL NPSLEYLTGS HVIEYSVFRT AAAMTSEEKK ERPLNMVSEA
AHYNLTSDYT AHPMSPLGRT SRSSKKVHNF GKRSNSIKRN PNAPVVRRGW LYKQDSTGMK
LWKKRWFVLS DLCLFYYRDE KEEGILGSIL LPSFQIAMLS SEDHINRKYA FKNVVPFSPQ
NDHVISNQAA HPNMRTYYFC TDTGKEMELW MKAMIDAALV QTEPVKRADK ITFENPAPRE
VNNIPNHREL IKPETQNNQR NREVCKTEEK KCLEAEKYGF QKVGRDRPLT KINSVKLNSY
GSEYGTLPAG ALSSGHYRPV HLNGSEKAVN LILGDSSDGI HHNAMHSHIE SERVIQRTNS
MLQLEQWIKI QRGKGQDEET RGIISYQTLP RNMPSHRAQV VPRYPEGYRT LPRNSKTRPD
SICSVTPLYD KTLGSLPAED KRRSMRDDTM WQLYEWQQRQ FYNKQTTLTR HGTLSSPKTM
INISDQAMHL IPTSPSHGSI AGFQGYSPQR NYRSEVSSPV QRGDVTIERR HRPHHNKQHG
FVPDRRSIPA GLSVQPITPQ SLQGKTPEEL TLLLIKLRRQ QAELSSIREH TLAQLMQLKL
EASSPKNEIL SHHLQRNAIY LDHQLTQDES RSTLYKYRSE ELDIDAKLSR LCEQDKVVQA
LEEKLQQLHK EKYTLEQALL SASQEIQMNA ENPAAIQNVV LQRDDLQNGL LSTCREVSRA
TAELERAWRE YDKLEYDVTI TKNHMQEQLE RTGEVQSESA GIQRAQIQKE LWRIQDVMEG
LSKHKQQRNS TTEAGIIALK TFSPKYKNEE EEVVPPRPPL PRSYDFAEQL PIIPPLPSDS
SSLLCYSRGP VHLPEERKIH QVQGYQRNGA HCGPDYRLYK SEPELTTVTE VDESNGEEKA
DPISESEASM TKGSHFPIGV VPPRTKSPTP ESSTIASYVT LRKTKKIDLR TERPRSAVEQ
LCLAESTRPR MTLEEQMERI RRHQQACLRE KKKGLNLIGI SDLSPSQSPA PVRENPFKLL
QSPRKEDFVC NPKEVEYGVR MSDKSQSHPN DVEDTPWLKE NDCANEHNPT FITQLPKNEE
QLFPDLLEPQ ERNPEQAPEK PEEQTGNSDA SSPNKEASLI NHKFESSSEE SEKSRIQEPQ
EDMVSSPFEM PAQTSKGNSA AAALLASAET IHG
//
