ID V8P9X3_OPHHA Unreviewed; 706 AA.
AC V8P9X3;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=FYN-binding protein {ECO:0000313|EMBL:ETE70697.1};
DE Flags: Fragment;
GN Name=FYB {ECO:0000313|EMBL:ETE70697.1};
GN ORFNames=L345_03491 {ECO:0000313|EMBL:ETE70697.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE70697.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE70697.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE70697.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE70697.1}.
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DR EMBL; AZIM01000496; ETE70697.1; -; Genomic_DNA.
DR AlphaFoldDB; V8P9X3; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:InterPro.
DR CDD; cd00174; SH3; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR043443; FYB1/2-like.
DR InterPro; IPR029294; hSH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR16830:SF13; FYN-BINDING PROTEIN 1; 1.
DR PANTHER; PTHR16830; SH2 CONTAINING ADAPTOR PRAM-1 RELATED; 1.
DR Pfam; PF14603; hSH3; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 452..512
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 42..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..224
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..333
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..410
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..545
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE70697.1"
SQ SEQUENCE 706 AA; 77971 MW; C253576FA4157C96 CRC64;
MAKFNNNAAE DVHCHQVRSG GHPPLAKKAA FEKFAQLENA GLSSKPNSLY KPTLLKSPPS
TKPLHDASGK DFKGPPLQSS PVANKVKMLA EAASREANEK TAYPKPLVPK ISEGLREETK
PVFPKIPEKK LPGSPPQKSE IKPLDQRLFK PEPQGSEAKP VFPTVAGVKE KFNSAAQENN
CKPPFPKPPV KHKPSQSFTQ GEEVSNKSAC FNQVSPSSSG LKSKAGSIRP LKDPQDKSRN
ETNPNSPFPP LKHVNHQNNL PQIPPKPVGQ QNEEAKPKPI KNIFLQNKQE EFGSTSGAIA
AKLANSSRTG TTGPWANNTG KEEKDKDKNL PRRKTLPSTM VLGPAPQKPN RPPTVDLQKF
RKSHGEGSSS SNSAGLPPPL PPPIHTRQST DLLSPAPPPL PPPGFRPSTQ TPVLPPRETI
PSRGQENEEN YDDVGFGSED TGNADELEGP IEVIHQARAS TDFKGGKYDL SFKQGDLIEI
LRVTDNPEGK WLGRLKGSYG YIKTTMVAID YDTLKRKPRP PMHVQSKYPD SDQEVYDDVG
DQDRFPPPPP DDIYDGVEDD EIPAKSVSQD EEKSDTWSKG LLKILKGKDY QKKSMREAAS
KVNMTEDENS FLGINIKSLN FGRGRSDQRD SQKFKKIDKE EKDFRKKFKY EGDIRVLYTT
TISKAPSPKK RGSKDLQVKP GELVEVIQDV DDTKVLCRNE EGKCKY
//
