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Database: UniProt
Entry: V8PAY2_OPHHA
LinkDB: V8PAY2_OPHHA
Original site: V8PAY2_OPHHA 
ID   V8PAY2_OPHHA            Unreviewed;      1698 AA.
AC   V8PAY2;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   25-OCT-2017, entry version 19.
DE   SubName: Full=Voltage-dependent R-type calcium channel subunit alpha-1E {ECO:0000313|EMBL:ETE71475.1};
DE   Flags: Fragment;
GN   Name=Cacna1e {ECO:0000313|EMBL:ETE71475.1};
GN   ORFNames=L345_02706 {ECO:0000313|EMBL:ETE71475.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE71475.1, ECO:0000313|Proteomes:UP000018936};
RN   [1] {ECO:0000313|EMBL:ETE71475.1, ECO:0000313|Proteomes:UP000018936}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE71475.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W.,
RA   Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M.,
RA   Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation
RT   in the snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ETE71475.1}.
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DR   EMBL; AZIM01000358; ETE71475.1; -; Genomic_DNA.
DR   Proteomes; UP000018936; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005449; VDCC_R_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF57; PTHR10037:SF57; 5.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 3.
DR   PRINTS; PR00167; CACHANNEL.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018936};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    143    163       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    169    187       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    208    226       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    685    704       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    716    737       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    752    772       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    816    838       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    941    959       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    971    994       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1065   1083       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1158   1182       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1319   1353       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      627    654       {ECO:0000256|SAM:Coils}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:ETE71475.1}.
SQ   SEQUENCE   1698 AA;  193900 MW;  AD90DCD1A3D0A034 CRC64;
     MFFCFQACNT KSSTFLLQRE FAKERERVEN RRAFMKLRRQ QQIERELNGY RAWIDKAEEV
     MLAEENKNSG TSALEVLRRA TIKRNRTEAM NRDSSDERVD ISSVGTPLAR SSIKSAKLDG
     ASYFRHKERL LRISVRHMVK SQVFYWLVLS IVALNTACVA IVHHKQPAWL THLLNYAEFI
     FLGLFLLEMS LKMYGMGPRL YFHSSFNCFD CGVTVGSIFE VVWAIFRPGT SFGISVLRAL
     RLLRIFKVTK FNFMDGTPSA NFDTFPAAIM TVFQDEQEEE EAFNQKHALQ KAKEVSPMSA
     PNMPAIERER RRRHHMSVWE QRTSQLRRHM QMSSQEGINK DDPPLLNPNA SIFRKRKLLE
     NSGLEKIEGD QGGRPEQTNG ESLEQKLPGS KPCPSIRDDQ RSPSPQAKRE WEEWHHKSFH
     GNCDINDQES KGSVSFDDRA RLRQSQRRSR HRRVRTEPKE NRTVSQENGP EGVTPAKGEQ
     NGDHKENGEE KETIAEKEPV ADMDLKRTSE ATANNAELPM PTQDPSPSEG HQMLDKSKEA
     SPVKQDGSSL ETSEQALLGD LSMETERTIS RSEPDLSSIT ANMDKATEST TIMIDVQDST
     VVQSKGLTRF VHFTVSNKTD GEASPLKEAE TKEEEEVEAE KKNKKRKKEK SSETGKPMVP
     HSSMFIFSTT NPIRRACHYV VNLRYFEMCI LLVIAASSIA LAAEDPVLTN SDRNKVLRYF
     DYVFTGVFTF EMVIKMIDQG LILQDGSYFR DLWNILDFIV VVGALMAFAL ASNKGRDIKT
     IKSLRVLRVL RPLKTIKRLP KLKAVFDCVV TSLKNVFNIL IVYKLFMFIF AVIAVQLFKG
     KFFYCTDSSK DTEKDCIGNY IDHEKNTMEV KCRQWKRHEF HYDNIIWALL TLFTVSTGEG
     WPQACIDFAI SAKPLTRYMP QNRHTFQYRV WHFVVSPSFE YTIMAMIALN TVVLMMKYYS
     APYTYELALK YLNIAFTMVF SLECVLKIIA FGFLNYFRDT WNIFDFITVI GSITEIILTD
     SKPTVTSSFN MSFLKLFRAA RLIKLLRQGY TIRILLWTFV QSFKALPYVC LLIAMLFFIY
     AIIGMQVFGN IKLDEESHIN RHNNFRSFLG SLMLLFRSAT GEAWQEIMLS CLEGKGCEPD
     TTATSGQNEN EKCGTELAYV YFVSFIFFCS FLMLNLFVAV IMDNFEYLTR DSSILGPHHL
     DEFVRIWAEY DRAACGRILY KDMYKLVRVI SPPLGLGEKC PCRVACKRLV LMNMPVAEDN
     TVHFTSTLMA LIRTALDIKI AKGGADWQQL DSELQKEILT IWPHLSQKML DLLVPMPKTT
     DLTVGKIYAA MMIMDYYKQS KAKKQRQQLE EQEPEIREFK RVQPSNCGSY LPVDTQERAV
     SGRASSMPRL TMDPQVVTDP GSMRRSFSTI RDKRTNSSWL DEFSMERSSE NTYKSRRRSY
     HSALHLSSRR LNTDSGHRSD THRSGGRERG RSKERRHLLS PDISRCNSEE RSPQADIDSP
     ERHHSRSPSE GRSQTPNRQG TGSLSESSIP SLSDTSTPRR SHRQLPPVPP KPRPLISYTA
     MMQHCGDTSP PPDDSEGGSP LLSGTLETNN TCLTESSSSL QGKQSLLSTP QRYISEPYLM
     LQDDSHASDC GEEETLTFEA AVATSLGRSN TIASGPRSRH GWQMPNGHYR RRRRGASQSM
     IYGAGIEVLS DTEEDDKC
//
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