ID V8PEN7_OPHHA Unreviewed; 1458 AA.
AC V8PEN7;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=N-acetylglucosamine-1-phosphotransferase subunits alpha/beta {ECO:0000313|EMBL:ETE72994.1};
DE Flags: Fragment;
GN Name=GNPTAB {ECO:0000313|EMBL:ETE72994.1};
GN ORFNames=L345_01158 {ECO:0000313|EMBL:ETE72994.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE72994.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE72994.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE72994.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SIMILARITY: Belongs to the stealth family.
CC {ECO:0000256|ARBA:ARBA00007583}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE72994.1}.
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DR EMBL; AZIM01000147; ETE72994.1; -; Genomic_DNA.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro.
DR CDD; cd21599; RRM1_GNPTAB; 1.
DR CDD; cd21600; RRM2_GNPTAB; 1.
DR Gene3D; 3.30.300.320; -; 1.
DR InterPro; IPR010506; DMAP1-bd.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR041536; GNPTAB_reg.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR047141; Stealth.
DR InterPro; IPR031358; Stealth_CR1.
DR InterPro; IPR021520; Stealth_CR2.
DR InterPro; IPR031357; Stealth_CR3.
DR InterPro; IPR031356; Stealth_CR4.
DR InterPro; IPR006888; XLR/SYCP3/FAM9_dom.
DR PANTHER; PTHR24045; -; 1.
DR PANTHER; PTHR24045:SF0; N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE SUBUNITS ALPHA_BETA; 1.
DR Pfam; PF04803; Cor1; 1.
DR Pfam; PF06464; DMAP_binding; 1.
DR Pfam; PF18440; GlcNAc-1_reg; 1.
DR Pfam; PF00066; Notch; 2.
DR Pfam; PF17101; Stealth_CR1; 1.
DR Pfam; PF11380; Stealth_CR2; 1.
DR Pfam; PF17102; Stealth_CR3; 1.
DR Pfam; PF17103; Stealth_CR4; 1.
DR SMART; SM01137; DMAP_binding; 1.
DR SMART; SM00004; NL; 2.
DR PROSITE; PS51912; DMAP1_BIND; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50258; LNR; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ETE72994.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 422..457
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 683..782
FT /note="DMAP1-binding"
FT /evidence="ECO:0000259|PROSITE:PS51912"
FT DOMAIN 990..1025
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT COILED 84..111
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1366..1414
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE72994.1"
SQ SEQUENCE 1458 AA; 167991 MW; DD405DE9BE98B18B CRC64;
LKLLQRQTYT CLSHRYGPCL CLGGIVLLLV SALQFGEVVL EWSRDQYHVL FDSYRDNVAG
KSFQNRLCLP MPIDVVYTWV NGTDVELMKE LQQVRKQMEE EQRTISEKQL ECLLTHCIKV
PMLVLDPALP NNVTLKDLPS VYPPLRSANN IFSVAKPKNP STNVTVVVFD TAKEAEDAHS
LMLKESIKQT AWRGYLTTDK EVPGLVIMQD LVFLKGFPLT FKETNQLRAK LPEILVSKIK
QLQLYSDASV ALLQLIDPKV FQELNKQAKK NMTIEGKELT LNPAYLLWDL SAISQSKQDE
DISPSRFEDN EELRYSLRSI EKHAPWVRHI FIVTNGQIPS WLNLDNPRVT IVTHQDIFQN
VSHLPTFSSP AIESHIHHIK DLSQKFVYLN DDVMFGKDVW PDDFYSHSKG QKVYLTWPVP
NCAEGCPGSW IKDGYCDKAC NNSACDWDGG DCIGNSVGSR YGAGAGAVGG LGNIPSWQFG
AGISGVSYCS QGCANSWLAD KFCDQACNVP SCGFDAGDCG QDHLGELYKV TLQKNQTHYI
IPKGESLPYF SFAEIAKKGL EGAYSDNPII RHASIANKWK TIHLLMHSGM NATVIHFNLT
FQSKDEEEFK MQITLEVDTR EESKLNITAT QQPAGDLKAT TSVPEAEMIF EDIPEERRFP
RVKKRLNSTS SNLDEEMVIQ AVNMSALPED VKIALQNLEL QLIVGDITQK GYNLSKAALL
RSRQLMPSET KMALNDLEES RKRDKGLKII GKTMLWQRSF QNDNEGKIVP TEKMHNTSLP
GFVPTGSILV EMKVTNDFSL SYRSTVKPTF VVRNMDKKHG FQVKALNTLM QKEIQERKIE
QQKKKEIDVN PAFSEEDIIE GPRRKLQYYT GNYQGFLPWE KHKYFQDLLD EEESLKKELA
YFTESKFVGR QLKDTFADSL RYVNKLLNGK FGFTSRKVPA HMPHMIDRKV MQELQDLFPE
EFDKTSFHKV RHSEDMQFAF SYFYYLMSAV QQLNISQVFD EIDTDHSGIL SDREIRTLAT
RIHELPLSLQ DLTGLEQMLI NCSKSLPLNI TQINIIPPTQ EAYYDPNLPP VTKGLLMNCK
LVTDRIRKAY KDKNKYRFEI MGEEEVAFKM IRTNVSHVVG QLDDIRKNPR KFVCLNDNID
HNHKDAQTVK AVLRDFYESM FPIPSQFELP REYRNRFLHT QELQEWRAYR DKLKFWTHCV
LVTLIVFTVT SFFAEQLIAL KRKIFPRRRI QKEVCYERMK KIMAPSGRKS TGKTTKQTQE
GSAVHVYRFE DDLKKHLSGS DEDIREDEAP VIDKHGKKRP VTPHAGVEDD VGKRLEMYTK
ASLKTSNQKI EFVWKTQQEQ RQKVNHEYSQ QFLHVFQQWD ADIQKAEEQE EKLNVFRQQQ
KAFQQARIVQ SQRLKTIKQL YEQFLKSMED MEKTHESLLA GAQSELRKEM SLWQKKIMMD
TQQQEMATVR KSLQSMLY
//
