GenomeNet

Database: UniProt
Entry: V8PG82_OPHHA
LinkDB: V8PG82_OPHHA
Original site: V8PG82_OPHHA 
ID   V8PG82_OPHHA            Unreviewed;       745 AA.
AC   V8PG82;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   25-OCT-2017, entry version 15.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
DE   Flags: Fragment;
GN   Name=ATP6V0A4 {ECO:0000313|EMBL:ETE73003.1};
GN   ORFNames=L345_01167 {ECO:0000313|EMBL:ETE73003.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE73003.1, ECO:0000313|Proteomes:UP000018936};
RN   [1] {ECO:0000313|EMBL:ETE73003.1, ECO:0000313|Proteomes:UP000018936}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE73003.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W.,
RA   Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M.,
RA   Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation
RT   in the snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ETE73003.1}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AZIM01000147; ETE73003.1; -; Genomic_DNA.
DR   Proteomes; UP000018936; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 2.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018936};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    378    401       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    422    441       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    518    536       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    548    571       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    583    603       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    703    727       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       93    127       {ECO:0000256|SAM:Coils}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:ETE73003.1}.
SQ   SEQUENCE   745 AA;  85394 MW;  A1000347C693AA95 CRC64;
     MASMFRSEEM CLRQLFLQVE SAYCCVAELG ELGLVQFRDL NATVNNFQRR FVNEVRRCES
     LERVLRFLES EMGEEILPVT YGKYPDTPPP REMIDLEAVL EKLEGELEEA NQNLQALRQN
     FLELTELKHL LKKTQDFFET ETNLPDDFFN EDTSGLLELR STPAAVAAKL GFIAGVIKRE
     RLVTFERLLW RACRGNIYLK FSEMDTPLED PVTKEEMKKN VFIIFYQGEQ LRQKIKKICE
     GFRATVYPCP ESATERREMA AGVNTRIEDL NTGLLKEASA NLWAWGIKVK KMKAIYHILN
     SCNIDVTQQC VIAEIWFPMV DTPRIKRALN QGMTKLEPPT FNRTNKFTAG FQAIVDAYGV
     GNYREINPAP FTIITFPFLF AVMFGDCGHG TVMLGFALWM ISNEKYFLAQ KSDSEIWNIF
     FSGRYLILLM SIFSIYTGFI YNDCFSKSFN IFGSSWRVRP MYNNGGWTDE IVHESGVLQL
     DPKTKGVYSG NPYPFGIDPI WNIAINKLTF LNSYKMKMSI IMGITHMVFG VVLSLFNHIY
     FKQTTNIVLQ FIPEMIFIIS LFGYLVFMII FKWCRFNQEV QTFLVIFALI AIPWMLLIQP
     FIIRAKHQKA QNRLASLSLS ENPTGDIEVE IMDSNHSEKT NQEVDSGGGH GGHDHEEFNF
     GDICVHQAIH TIEYCLGCIS NTASYLRLWA LSLAHARFKM TGWIGLIGIF VLFAIFAALT
     VAILLIMEGL SAFLHALRLH CFQLN
//
DBGET integrated database retrieval system