ID V8PHV6_OPHHA Unreviewed; 941 AA.
AC V8PHV6;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 22-FEB-2023, entry version 23.
DE SubName: Full=Cysteine-rich motor neuron 1 protein {ECO:0000313|EMBL:ETE73541.1};
DE Flags: Fragment;
GN Name=CRIM1 {ECO:0000313|EMBL:ETE73541.1};
GN ORFNames=L345_00621 {ECO:0000313|EMBL:ETE73541.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE73541.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE73541.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE73541.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE73541.1}.
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DR EMBL; AZIM01000077; ETE73541.1; -; Genomic_DNA.
DR AlphaFoldDB; V8PHV6; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR Gene3D; 6.20.200.20; -; 5.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR InterPro; IPR004094; Antistasin-like.
DR InterPro; IPR045813; CRIM1_C.
DR InterPro; IPR011061; Hirudin/antistatin.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR46439; CYSTEINE-RICH MOTOR NEURON 1 PROTEIN; 1.
DR PANTHER; PTHR46439:SF1; CYSTEINE-RICH MOTOR NEURON 1 PROTEIN; 1.
DR Pfam; PF02822; Antistasin; 3.
DR Pfam; PF19442; CRIM1_C; 1.
DR Pfam; PF00093; VWC; 6.
DR SMART; SM00214; VWC; 6.
DR SMART; SM00215; VWC_out; 3.
DR SUPFAM; SSF57603; FnI-like domain; 6.
DR SUPFAM; SSF57262; Leech antihemostatic proteins; 1.
DR PROSITE; PS51252; ANTISTASIN; 3.
DR PROSITE; PS01208; VWFC_1; 3.
DR PROSITE; PS50184; VWFC_2; 6.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 846..866
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 184..241
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 251..307
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 319..348
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 355..382
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 472..497
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 511..568
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 582..640
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 656..714
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 722..779
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE73541.1"
SQ SEQUENCE 941 AA; 104118 MW; 918C183D1D709BFE CRC64;
MDDRQTDNNH YCNVTGWVEE KPDCSKARCE VQFSPRCPED SILIEGYAPP GECCPLPSRC
VCNPAGCLRK VCQPGYLNIL VSKASGKPGE CCDFYECKPV FSVDCSTVEC PPVQQVACPL
DSYETQVRLT ADGCCTLPTR CECLSGLCGV PKCEPGFIPQ IVSRGDGTPG KCCDVFECVN
EVKPACIFNS VEYNDGDMFR MDTCRFCQCQ GGVSICFSAQ CGELHCDRYY VPEGECCPVC
EDSISPISNP AGCYANGQIQ AHGDRWREDD CTFCQCINGE SHCVATACGQ SCLNPVKVPG
ECCPMCEEPT YITIGPPTCP PLVNCTLKVT DCIYDFKVDQ NGCRICQCKT REERCTDLMS
DCSLDCDFGF QTDVHNCKIC QCHPRPKKCK PIVCDKYCPF GYLYSYDLFH PTTSQSHIYL
LKNFKAQEVK GRKIRQSIAG TNGTIEEKKS CQFSFHPSKN KHGCEICRCK KCPELSCGKI
CPMGFQKNNQ GCNICKCAEI PASIIPPAKV GTCLSIDGHR HENEESWHDG CRDCYCHNGR
EMCALITCSV PNCGNPTIHP GQCCPSCPDE SIAQKPEISG PTICYVPGGE YFMEGDTWNI
DSCTQCTCHN ARVLCETEVC PPLLCRNPTR TQDSCCPQCP DEPVQPSLST NKSMPSYCKN
DDGDIFLTAE SWKPNVCTSC ICLDGGISCY SESCPPVSCE KPVLRKGQCC PYCIEDTAAK
KAVCHFNGKT YADEERWDID SCTHCYCLQG QTLCSTVSCP SLPCVEPINV EGSCCPMCPE
MYVPEPTNIP IEKTNHRGDK ELEAPVWPTF SENDVVHIRK DMGHLQGEYR ETRGSQPTAE
ASLDSLAWVT VPLLTAVVLI IALLFINQKK QWIPVSCYRT PAKPSCLNNQ LVYVDCKKGT
MVQVDSSQRM LRIADPDSRY SGFYSMQKQS NLQADNFYQT V
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