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Database: UniProt
Entry: V8PJJ7_OPHHA
LinkDB: V8PJJ7_OPHHA
Original site: V8PJJ7_OPHHA 
ID   V8PJJ7_OPHHA            Unreviewed;      2056 AA.
AC   V8PJJ7;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   SubName: Full=Echinoderm microtubule-associated protein-like 6 {ECO:0000313|EMBL:ETE74121.1};
DE   Flags: Fragment;
GN   Name=EML6 {ECO:0000313|EMBL:ETE74121.1};
GN   ORFNames=L345_00055 {ECO:0000313|EMBL:ETE74121.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE74121.1, ECO:0000313|Proteomes:UP000018936};
RN   [1] {ECO:0000313|EMBL:ETE74121.1, ECO:0000313|Proteomes:UP000018936}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE74121.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA   Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT   snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- FUNCTION: May modify the assembly dynamics of microtubules, such that
CC       microtubules are slightly longer, but more dynamic.
CC       {ECO:0000256|ARBA:ARBA00003210}.
CC   -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC       {ECO:0000256|ARBA:ARBA00006489}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETE74121.1}.
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DR   EMBL; AZIM01000004; ETE74121.1; -; Genomic_DNA.
DR   Proteomes; UP000018936; Unassembled WGS sequence.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 7.
DR   InterPro; IPR024977; Apc4-like_WD40_dom.
DR   InterPro; IPR005108; HELP.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR13720:SF52; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 6; 1.
DR   PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR   Pfam; PF12894; ANAPC4_WD40; 2.
DR   Pfam; PF03451; HELP; 3.
DR   Pfam; PF00400; WD40; 10.
DR   SMART; SM00320; WD40; 28.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 3.
DR   SUPFAM; SSF50978; WD40 repeat-like; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}.
FT   DOMAIN          4..48
FT                   /note="HELP"
FT                   /evidence="ECO:0000259|Pfam:PF03451"
FT   REPEAT          348..363
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          428..460
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   DOMAIN          471..558
FT                   /note="Anaphase-promoting complex subunit 4-like WD40"
FT                   /evidence="ECO:0000259|Pfam:PF12894"
FT   REPEAT          502..533
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          586..618
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   DOMAIN          695..742
FT                   /note="HELP"
FT                   /evidence="ECO:0000259|Pfam:PF03451"
FT   REPEAT          1266..1298
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   DOMAIN          1374..1433
FT                   /note="HELP"
FT                   /evidence="ECO:0000259|Pfam:PF03451"
FT   REPEAT          1715..1756
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   DOMAIN          1767..1843
FT                   /note="Anaphase-promoting complex subunit 4-like WD40"
FT                   /evidence="ECO:0000259|Pfam:PF12894"
FT   REGION          63..132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1354..1382
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        65..104
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        112..132
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ETE74121.1"
SQ   SEQUENCE   2056 AA;  227714 MW;  2308FC8B58931F7E CRC64;
     MADRTAPRCQ LHLEWVYGYR GHQCRNNLYY TAGKEVVYFV AGVGVVYNTR EHTQKFFLGH
     NDDIISQGTG RSSSSPNGVM GHNPKCTPNA LHTSTIQDAD SNPENPQPHV PGEAGDQQQG
     NCGSTPEEVN TAQGEFPQVP GAEQEAAADP TGLTAASLSN DLHSLALHPD KTLVATGQVG
     KDPYICIWDS YNVQAVSVLK DAHTHGVACL AFDSDGQRLS SVGLDAKNTV CIWDWKKGKL
     LASATGHSDR IFDISWDPYQ PNRVASCGVK HIKFWTLCGN ALTAKRGIFG KTGDLQTILC
     LSCAKDDVTF SGALNGDVYV WKGLTLVRTI QGAHGAGIFS MYGCEEGFAT GGRDGCIRLW
     DIDFKPITKI DLRETEQGYK GLSIRSVCWK ADRLLAGTQD SEIFEIIVRE RDKPMLIMQG
     HCEGELWALA VHPKKPLVVT GSDDRSVRLW SLADHALIAR CNMEEAVRSV SFSPDGSQLA
     LGMKDGSFIV LRVRDMTEVV HIKDRKEVIH EMKFSPDGCY LAVGSNDGQV DIYAVAQRFK
     KTGECSKSSS FITHIDWSLD SKFLQTNDGA GARFFYRMPC AKFRKYVGHS AHVTNVRWSH
     DFQWVISTGG ADHSVFQWRF IPEGVTTGIL EAARIECGID SYSEESDSDL SDVPELDSDI
     EQEAQINYVR QVYKEDLPQL KQQRKEKSHS VPCLKRERAP DDSLKLQFIH GYRGYDCRNN
     LFYTQTGEVV YHIAAVAVVY NRQQHTQRLY LGHDDDILSL AIHPMKDYVA TGQVGRDAAI
     HIWDIQMLKC LSLLRGQHQR GICALDFSAD GKCLASIGLD DNHTIVLWDW KKGEKMAVTR
     GHKDKLFVVK CNPHHADKLV TVGIKHIKFW QQTGGGFTSK RGMFGNIGKQ ETMMSISYGR
     IEDLVFSGSA TGDIYIWKDV LLVKTQIYKS VSLQGFVTGG KDGVVALWDD TFERCLKTYA
     IKRAALSPGS KGLLLEDNPS IRAITLGHGH ILVGTKNGEI LEIDKTGPMT LLVQGHMEGE
     VWGLAAHPLL PICATVSDDK TLRIWELSSQ HRMLAVRKLK KGGRCCAFSP DGKALAVGLN
     DGSFLVVNAD TLEDMLSFHH RKEMISDIKF SRGQNSGKYL AVASHDNFVD IYNVLTSKRV
     GICKGASSYV THIDWDSRGK LLQVNSGAKE QIFFEAPRGK RHIIRSMEIE KIEWDTWTCV
     LGPTCEGIWP MHSDVTVINA ASLTKDSTLL ATGDDFGFVK LFRYPVKEKD YDLPVLQGQH
     AKFKKYVGHS SHVTNVRWLH NDSVLLTVGG ADTALMIWTR EFVGTQESKL VDSEESDTDA
     EEDGGYDSDV AREKAIDYTT KIYAVSIREM EGTKPHQQLK EVSVEERPPV SRAAPQPEKL
     QKNNINKKKK VVEELCLDHV FGYRGFDCRN NLHYLNDGAD IIFHTAAACI VQNLSTGSQS
     FYLEHTDDIL CLTVNQHPKY KNIVATSQIG TTPSIHIWDA MTKQTLSMLR CFHSKGVNYV
     NFSATGKLLV SLGVDPEHTI TVWRWQEGAK IASRGGHLER IFVVEFRPDS DTQFVSVGVK
     HMKFWTLAGS ALLYKKGVIG SLDDAKMQTM LSVAFGANNL TFTGAINGDV YVWKDHFLVR
     LVAKAHTGPV FTMYTTLRDG LIVTGGKERP TKEGGAVKLW DQEMKRCRAF QLETGQIVEC
     VRSVCRGKGK ILVGTKDGEI LEVGEKNGAS NLLIDSHMEG EIWGLATHPS KDIFISASND
     GTARIWDLCD KKLLNKVNLG HAARCAAYSP DGEMVAIGMK NGEFIILLVN SLKVWGKKRD
     RKSAIQDISP DNRFLAVGSQ EHTVDFYDLT QGTTLNRIGY CKDIPSFVIQ MDFSADGKYI
     QVSTGAYKRQ VHELIFLLWS SILGDEVIGI WPRNADKADV NCACVTHAGL NIVSGDDFGL
     VKLFDFPCTE KFVKIVSFLD RPNISVTLVI LHMSPTYAFL MMTSMLSAQE EMTAVYLYGD
     AFKGYNSQGT FLPPLPFECQ TLQPPSFMSG AVPGDLCSRR ACVLGVGAAS AIGIGAQIVR
     PNQPGSAVTK KTIRLV
//
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