ID V8PJJ7_OPHHA Unreviewed; 2056 AA.
AC V8PJJ7;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=Echinoderm microtubule-associated protein-like 6 {ECO:0000313|EMBL:ETE74121.1};
DE Flags: Fragment;
GN Name=EML6 {ECO:0000313|EMBL:ETE74121.1};
GN ORFNames=L345_00055 {ECO:0000313|EMBL:ETE74121.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE74121.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE74121.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE74121.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- FUNCTION: May modify the assembly dynamics of microtubules, such that
CC microtubules are slightly longer, but more dynamic.
CC {ECO:0000256|ARBA:ARBA00003210}.
CC -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC {ECO:0000256|ARBA:ARBA00006489}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE74121.1}.
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DR EMBL; AZIM01000004; ETE74121.1; -; Genomic_DNA.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 7.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF52; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 6; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF12894; ANAPC4_WD40; 2.
DR Pfam; PF03451; HELP; 3.
DR Pfam; PF00400; WD40; 10.
DR SMART; SM00320; WD40; 28.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 3.
DR SUPFAM; SSF50978; WD40 repeat-like; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 4..48
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 348..363
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 428..460
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 471..558
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 502..533
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 586..618
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 695..742
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 1266..1298
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1374..1433
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 1715..1756
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1767..1843
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REGION 63..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1354..1382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE74121.1"
SQ SEQUENCE 2056 AA; 227714 MW; 2308FC8B58931F7E CRC64;
MADRTAPRCQ LHLEWVYGYR GHQCRNNLYY TAGKEVVYFV AGVGVVYNTR EHTQKFFLGH
NDDIISQGTG RSSSSPNGVM GHNPKCTPNA LHTSTIQDAD SNPENPQPHV PGEAGDQQQG
NCGSTPEEVN TAQGEFPQVP GAEQEAAADP TGLTAASLSN DLHSLALHPD KTLVATGQVG
KDPYICIWDS YNVQAVSVLK DAHTHGVACL AFDSDGQRLS SVGLDAKNTV CIWDWKKGKL
LASATGHSDR IFDISWDPYQ PNRVASCGVK HIKFWTLCGN ALTAKRGIFG KTGDLQTILC
LSCAKDDVTF SGALNGDVYV WKGLTLVRTI QGAHGAGIFS MYGCEEGFAT GGRDGCIRLW
DIDFKPITKI DLRETEQGYK GLSIRSVCWK ADRLLAGTQD SEIFEIIVRE RDKPMLIMQG
HCEGELWALA VHPKKPLVVT GSDDRSVRLW SLADHALIAR CNMEEAVRSV SFSPDGSQLA
LGMKDGSFIV LRVRDMTEVV HIKDRKEVIH EMKFSPDGCY LAVGSNDGQV DIYAVAQRFK
KTGECSKSSS FITHIDWSLD SKFLQTNDGA GARFFYRMPC AKFRKYVGHS AHVTNVRWSH
DFQWVISTGG ADHSVFQWRF IPEGVTTGIL EAARIECGID SYSEESDSDL SDVPELDSDI
EQEAQINYVR QVYKEDLPQL KQQRKEKSHS VPCLKRERAP DDSLKLQFIH GYRGYDCRNN
LFYTQTGEVV YHIAAVAVVY NRQQHTQRLY LGHDDDILSL AIHPMKDYVA TGQVGRDAAI
HIWDIQMLKC LSLLRGQHQR GICALDFSAD GKCLASIGLD DNHTIVLWDW KKGEKMAVTR
GHKDKLFVVK CNPHHADKLV TVGIKHIKFW QQTGGGFTSK RGMFGNIGKQ ETMMSISYGR
IEDLVFSGSA TGDIYIWKDV LLVKTQIYKS VSLQGFVTGG KDGVVALWDD TFERCLKTYA
IKRAALSPGS KGLLLEDNPS IRAITLGHGH ILVGTKNGEI LEIDKTGPMT LLVQGHMEGE
VWGLAAHPLL PICATVSDDK TLRIWELSSQ HRMLAVRKLK KGGRCCAFSP DGKALAVGLN
DGSFLVVNAD TLEDMLSFHH RKEMISDIKF SRGQNSGKYL AVASHDNFVD IYNVLTSKRV
GICKGASSYV THIDWDSRGK LLQVNSGAKE QIFFEAPRGK RHIIRSMEIE KIEWDTWTCV
LGPTCEGIWP MHSDVTVINA ASLTKDSTLL ATGDDFGFVK LFRYPVKEKD YDLPVLQGQH
AKFKKYVGHS SHVTNVRWLH NDSVLLTVGG ADTALMIWTR EFVGTQESKL VDSEESDTDA
EEDGGYDSDV AREKAIDYTT KIYAVSIREM EGTKPHQQLK EVSVEERPPV SRAAPQPEKL
QKNNINKKKK VVEELCLDHV FGYRGFDCRN NLHYLNDGAD IIFHTAAACI VQNLSTGSQS
FYLEHTDDIL CLTVNQHPKY KNIVATSQIG TTPSIHIWDA MTKQTLSMLR CFHSKGVNYV
NFSATGKLLV SLGVDPEHTI TVWRWQEGAK IASRGGHLER IFVVEFRPDS DTQFVSVGVK
HMKFWTLAGS ALLYKKGVIG SLDDAKMQTM LSVAFGANNL TFTGAINGDV YVWKDHFLVR
LVAKAHTGPV FTMYTTLRDG LIVTGGKERP TKEGGAVKLW DQEMKRCRAF QLETGQIVEC
VRSVCRGKGK ILVGTKDGEI LEVGEKNGAS NLLIDSHMEG EIWGLATHPS KDIFISASND
GTARIWDLCD KKLLNKVNLG HAARCAAYSP DGEMVAIGMK NGEFIILLVN SLKVWGKKRD
RKSAIQDISP DNRFLAVGSQ EHTVDFYDLT QGTTLNRIGY CKDIPSFVIQ MDFSADGKYI
QVSTGAYKRQ VHELIFLLWS SILGDEVIGI WPRNADKADV NCACVTHAGL NIVSGDDFGL
VKLFDFPCTE KFVKIVSFLD RPNISVTLVI LHMSPTYAFL MMTSMLSAQE EMTAVYLYGD
AFKGYNSQGT FLPPLPFECQ TLQPPSFMSG AVPGDLCSRR ACVLGVGAAS AIGIGAQIVR
PNQPGSAVTK KTIRLV
//