ID V8QZA1_9PSED Unreviewed; 197 AA.
AC V8QZA1;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=HTH-type transcriptional regulator BetI {ECO:0000256|HAMAP-Rule:MF_00768};
GN Name=betI {ECO:0000256|HAMAP-Rule:MF_00768};
GN ORFNames=PMO01_25345 {ECO:0000313|EMBL:ETF04967.1};
OS Pseudomonas moraviensis R28-S.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=1395516 {ECO:0000313|EMBL:ETF04967.1, ECO:0000313|Proteomes:UP000024771};
RN [1] {ECO:0000313|EMBL:ETF04967.1, ECO:0000313|Proteomes:UP000024771}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R28 {ECO:0000313|Proteomes:UP000024771};
RX PubMed=24558233;
RA Hunter S.S., Yano H., Loftie-Eaton W., Hughes J., De Gelder L.,
RA Stragier P., De Vos P., Settles M.L., Top E.M.;
RT "Draft Genome Sequence of Pseudomonas moraviensis R28-S.";
RL Genome Announc. 2:e00035-14(2014).
CC -!- FUNCTION: Repressor involved in choline regulation of the bet genes.
CC {ECO:0000256|HAMAP-Rule:MF_00768}.
CC -!- FUNCTION: Repressor involved in the biosynthesis of the osmoprotectant
CC glycine betaine. It represses transcription of the choline transporter
CC BetT and the genes of BetAB involved in the synthesis of glycine
CC betaine. {ECO:0000256|ARBA:ARBA00024936}.
CC -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via
CC choline pathway [regulation]. {ECO:0000256|ARBA:ARBA00004719,
CC ECO:0000256|HAMAP-Rule:MF_00768}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETF04967.1}.
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DR EMBL; AYMZ01000012; ETF04967.1; -; Genomic_DNA.
DR RefSeq; WP_024014607.1; NZ_CM002330.1.
DR AlphaFoldDB; V8QZA1; -.
DR PATRIC; fig|1395516.4.peg.5136; -.
DR eggNOG; COG1309; Bacteria.
DR HOGENOM; CLU_069356_15_4_6; -.
DR UniPathway; UPA00529; -.
DR Proteomes; UP000024771; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR HAMAP; MF_00768; HTH_type_BetI; 1.
DR InterPro; IPR039538; BetI_C.
DR InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR InterPro; IPR017757; Tscrpt_rep_BetI.
DR NCBIfam; TIGR03384; betaine_BetI; 1.
DR PANTHER; PTHR30055:SF254; HTH-TYPE TRANSCRIPTIONAL REGULATOR BETI; 1.
DR PANTHER; PTHR30055; HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR; 1.
DR Pfam; PF13977; TetR_C_6; 1.
DR Pfam; PF00440; TetR_N; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF48498; Tetracyclin repressor-like, C-terminal domain; 1.
DR PROSITE; PS01081; HTH_TETR_1; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_00768, ECO:0000256|PROSITE-
KW ProRule:PRU00335};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00768};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00768};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00768}.
FT DOMAIN 8..68
FT /note="HTH tetR-type"
FT /evidence="ECO:0000259|PROSITE:PS50977"
FT DNA_BIND 31..50
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00768,
FT ECO:0000256|PROSITE-ProRule:PRU00335"
SQ SEQUENCE 197 AA; 21826 MW; 1D41BE2BA39FF54F CRC64;
MPKVGMQPIR RQQLIEATLQ AVDQVGMGDA SIALIARLAG VSNGIISHYF QDKNGLIAAT
MRYLMTALSE SVTARRQALA DDSPRAHLQV IIEGNFDASQ VNGPAMKTWL AFWATSMHQP
SLHRLQRIND HRLYSNLCCQ FRRVLPLEDA RNAARGLAAL IDGLWLRGAL SGDAFDTAQA
QQIAYEYMDF QLAKKVS
//
