ID V9E645_PHYPR Unreviewed; 1074 AA.
AC V9E645;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=F443_18954 {ECO:0000313|EMBL:ETI34565.1};
OS Phytophthora parasitica P1569.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=1317065 {ECO:0000313|EMBL:ETI34565.1, ECO:0000313|Proteomes:UP000018721};
RN [1] {ECO:0000313|EMBL:ETI34565.1, ECO:0000313|Proteomes:UP000018721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P1569 {ECO:0000313|EMBL:ETI34565.1,
RC ECO:0000313|Proteomes:UP000018721};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica P1569.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETI34565.1}.
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DR EMBL; ANIZ01003313; ETI34565.1; -; Genomic_DNA.
DR AlphaFoldDB; V9E645; -.
DR EnsemblProtists; ETI34565; ETI34565; F443_18954.
DR OrthoDB; 65703at2759; -.
DR Proteomes; UP000018721; Unassembled WGS sequence.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 4.
DR Gene3D; 3.30.70.1390; ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR032171; COR.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020859; ROC_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR24193:SF121; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24193; ANKYRIN REPEAT PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF16095; COR; 1.
DR Pfam; PF08477; Roc; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 9.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 8.
DR PROSITE; PS50088; ANK_REPEAT; 8.
DR PROSITE; PS51424; ROC; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000018721};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022777}.
FT REPEAT 40..72
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 73..107
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 108..140
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 141..173
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 174..206
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 207..239
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 240..272
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 273..305
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 400..623
FT /note="Roc"
FT /evidence="ECO:0000259|PROSITE:PS51424"
SQ SEQUENCE 1074 AA; 121368 MW; 1AD76CE0A6F48D5A CRC64;
MKCKQEESLK RVWDKSDQEA AAAIITLLHQ GVDAKSPDGG AAIALQYALR NSRADVISLL
LERGADVNSQ DEFGDTALHR AIEQYRGNTA VISLLLQRGA DAAVQNVDGQ NALHYAAAIA
NSEAISLLLK QGIDIDAQDE TGQTVLHYAT VIANTEVMSL LLEQGADVGT QDEDGKTALH
YAVTSHNTDV MSLLLERGAD LAARYEDDET ILHYAVRNGD VDVISLLLEK GADVAATDNN
GEIALHYAAS FGHTERILLL LDRGSDVNAS DNDQLTVLHH AVTRCSPEAV LLLLNKGADA
NALTKDGLNP LSHMILVKED DPDDDYLGVV RLLCSQEPKL KLPPSTQSLA INQLGMLACA
QYWQDRYEKK QPLLEIPSEV VKGGENAVEM YLAELEKTDS SEVVHRQKIC VVGRTKWGKT
SLVRSITEET SVLVPLEDRT IGIEVFPLRF TVDGDGNKMK ATHHDVTFWD FAGQGVYRVA
HAVFFSKRTL YLVCVDLAAY NEILEQAKKE SKTQRDEVPQ RFFEKHILRW IVLILLRQPE
AEFKLIGTKH DEVSDSSRSE ISHDIRDRLG QFLEKLDGSI QITGHAATAL KKEFEEGLVT
TSVTNVESIQ KVKNSIKHTI TAKPHLSFKM PITYTRVINY ILEKRQSVVG ATNQDRMDKM
IVSVRQLCKD LLKLPDFPQD TDCREILRVL HELGDVLWYK GIDEELEKWI ILDPSVVLDL
VREVINHKYK EEVDEQYKVL SQNGILPHSL LMTFPSWKSL AAVEDKMVHL FKQLLHRLNL
VYPVNDMEAI DKADILVPMY WKTRETPKAD LKLLATQKTI LTQDFGDSWH VATWRYWLPI
VVSDAIFVNF VVKCYRPFVH RSARRAYFES SVRREFRAVV NHSANKTGQY NDILIEVAAP
TEKLAWAEMM YFVTDMEKIL EKDYPGLTKH ARVKRFIVDD GEDRGVNDLM ENPEDGKRQR
AKARWLPPDF SWFTQCAWKN GGVYEIHQLR HQLEAVKNIV VTSESCRLPR LWTLLYPRKG
SHVELRIHSD VSDVSVLYFC PVSSLCSHPQ CRGCCRRESS FRSVEIGIKP KDHG
//
