ID V9ENV6_PHYPR Unreviewed; 752 AA.
AC V9ENV6;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=alpha-1,2-Mannosidase {ECO:0000256|RuleBase:RU361193};
DE EC=3.2.1.- {ECO:0000256|RuleBase:RU361193};
GN ORFNames=F443_13768 {ECO:0000313|EMBL:ETI40930.1};
OS Phytophthora parasitica P1569.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=1317065 {ECO:0000313|EMBL:ETI40930.1, ECO:0000313|Proteomes:UP000018721};
RN [1] {ECO:0000313|EMBL:ETI40930.1, ECO:0000313|Proteomes:UP000018721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P1569 {ECO:0000313|EMBL:ETI40930.1,
RC ECO:0000313|Proteomes:UP000018721};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica P1569.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 47 family.
CC {ECO:0000256|ARBA:ARBA00007658, ECO:0000256|RuleBase:RU361193}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETI40930.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ANIZ01002401; ETI40930.1; -; Genomic_DNA.
DR AlphaFoldDB; V9ENV6; -.
DR EnsemblProtists; ETI40930; ETI40930; F443_13768.
DR eggNOG; KOG2430; Eukaryota.
DR HOGENOM; CLU_003818_4_1_1; -.
DR OrthoDB; 942598at2759; -.
DR Proteomes; UP000018721; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004571; F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR044674; EDEM1/2/3.
DR InterPro; IPR001382; Glyco_hydro_47.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR036026; Seven-hairpin_glycosidases.
DR PANTHER; PTHR45679; ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR45679:SF6; ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2; 1.
DR Pfam; PF01532; Glyco_hydro_47; 1.
DR Pfam; PF02225; PA; 1.
DR PRINTS; PR00747; GLYHDRLASE47.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF48225; Seven-hairpin glycosidases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycosidase {ECO:0000256|RuleBase:RU361193};
KW Hydrolase {ECO:0000256|RuleBase:RU361193};
KW Reference proteome {ECO:0000313|Proteomes:UP000018721};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..752
FT /note="alpha-1,2-Mannosidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004774738"
FT DOMAIN 641..726
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT ACT_SITE 132
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT ACT_SITE 275
FT /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT ACT_SITE 370
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT ACT_SITE 400
FT /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
SQ SEQUENCE 752 AA; 83141 MW; BF55581484054D55 CRC64;
MTPRQVYPMC LRLAFLLVSV ALVGTLCSAH MHVSERRHLQ QQARDMFYHG YRNYMKHAYP
WDELKPLSCS GRRWDRRERG DLDDVLGGFS LTLVDSLDML AVLGDCDEFA RAVKLISSSV
SFDRDVTVSV FESTIRVIGG LVSAHMLASP EYFGLMDEHE YNGELLELAE DLGRRILPAF
ETPTGIPVHR INLQRGVLPK DRAANLTCPA AAGSLLVEMA YLSRLTGDES FEERAKQAVV
AIWDRRSDLD LLGSSIDVGS GQWIYSHGGI GAGLDSFFEY LLKYHLISGD SGWLEMFNAS
YHAVETHVNH NDVYIEVDMN GGRNQVRARR VSALQAFWPG LQVLAGDVSG AIRTHEHMFP
LWDEYGAMPE LLDLAPHGKS KPGNRGTVIS WARTSPLRPE LIESTYHLYQ ATKDHKYLKM
GRQMLQDIRR VSEVPCGYAA VGDIHTLDVE DRMDSYFLSE TAKYLFLLFS DDNVIVPAPI
RQRNATATNR TCSATVSDDK ITLGSSLSCN NRTINGNSTL EHSSYVRRNR KPLKASDVVF
STEGHILMLD SHLFRHTTKQ KASSASPKCE NGKLQVHRRN VELEVARRGQ LTPPVIPVGV
AVRIGGVHVT TLVASPAKFG LQVTTPSAVE APLLLFTPDI GEACGSVDSD RVHGKIVMVA
RGKCTFAEKA LRLQSAGAVG IVVINSKASS SRYPNRKYSL ADDARGLGQY VTIPVVLVAR
EDATQLHRHA SLNNVQSDSG AVLIGSLSPW LY
//